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Q83FA3

- NTPA_COXBU

UniProt

Q83FA3 - NTPA_COXBU

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Protein

Non-canonical purine NTP pyrophosphatase

Gene
CBU_0043
Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions By similarity.UniRule annotation

Catalytic activityi

A nucleoside triphosphate + H2O = a nucleotide + diphosphate.UniRule annotation

Cofactori

Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi40 – 401Magnesium or manganese By similarity
Metal bindingi69 – 691Magnesium or manganese By similarity
Binding sitei157 – 1571Substrate By similarity
Binding sitei177 – 1771Substrate By similarity
Binding sitei183 – 1831Substrate By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. nucleoside-triphosphatase activity Source: InterPro
  3. nucleoside-triphosphate diphosphatase activity Source: UniProtKB-HAMAP
  4. nucleotide binding Source: UniProtKB-KW

GO - Biological processi

  1. nucleoside triphosphate catabolic process Source: InterPro
  2. purine nucleotide metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-47-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Non-canonical purine NTP pyrophosphatase (EC:3.6.1.19)
Alternative name(s):
Non-standard purine NTP pyrophosphatase
Nucleoside-triphosphate diphosphatase
Nucleoside-triphosphate pyrophosphatase
Short name:
NTPase
Gene namesi
Ordered Locus Names:CBU_0043
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 200200Non-canonical purine NTP pyrophosphataseUniRule annotationPRO_0000178160Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi227377.CBU_0043.

Structurei

Secondary structure

1
200
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 65
Helixi11 – 2010
Turni21 – 233
Beta strandi24 – 307
Helixi31 – 344
Helixi46 – 6116
Beta strandi65 – 7410
Helixi75 – 773
Helixi82 – 843
Turni85 – 895
Helixi95 – 10915
Beta strandi115 – 12713
Beta strandi134 – 14411
Beta strandi151 – 1533
Helixi157 – 1593
Turni163 – 1653
Beta strandi166 – 1683
Turni169 – 1713
Helixi174 – 1807
Helixi182 – 19615

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3TQUX-ray1.90A/B/C/D1-200[»]
ProteinModelPortaliQ83FA3.
SMRiQ83FA3. Positions 1-195.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni8 – 136Substrate binding By similarity
Regioni69 – 702Substrate binding By similarity

Sequence similaritiesi

Belongs to the HAM1 NTPase family.

Phylogenomic databases

eggNOGiCOG0127.
HOGENOMiHOG000293319.
KOiK02428.
OMAiRQAKFVS.
OrthoDBiEOG6CZQQP.

Family and domain databases

Gene3Di3.90.950.10. 1 hit.
HAMAPiMF_01405. Non_canon_purine_NTPase.
InterProiIPR002637. Ham1p-like.
IPR029001. ITPase-like_fam.
IPR020922. NTPase.
[Graphical view]
PANTHERiPTHR11067. PTHR11067. 1 hit.
PfamiPF01725. Ham1p_like. 1 hit.
[Graphical view]
SUPFAMiSSF52972. SSF52972. 1 hit.
TIGRFAMsiTIGR00042. TIGR00042. 1 hit.

Sequencei

Sequence statusi: Complete.

Q83FA3-1 [UniParc]FASTAAdd to Basket

« Hide

MLEIVLASQN SSKLAEMQEL LRDLEIKFIP QTEFSVPDIE ETGSTFVENA    50
IIKARHAAKQ TGLPALADDS GLTIAALNSA PGVFSSRYAG KNATDAERIQ 100
KVLEALEAAD DSDRSASFHC VIALMENEND PAPLICHGVW EGEIAREPRG 150
KNGFGYDPIF YVPSHQRTAA ELDPQEKNAI SHRGQALEQL STVLTEAFLV 200
Length:200
Mass (Da):21,777
Last modified:June 1, 2003 - v1
Checksum:iA35DF16EE7025113
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016828 Genomic DNA. Translation: AAO89612.1.
RefSeqiNP_819098.1. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO89612; AAO89612; CBU_0043.
GeneIDi1207905.
KEGGicbu:CBU_0043.
PATRICi17928763. VBICoxBur82552_0044.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016828 Genomic DNA. Translation: AAO89612.1 .
RefSeqi NP_819098.1. NC_002971.3.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3TQU X-ray 1.90 A/B/C/D 1-200 [» ]
ProteinModelPortali Q83FA3.
SMRi Q83FA3. Positions 1-195.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227377.CBU_0043.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO89612 ; AAO89612 ; CBU_0043 .
GeneIDi 1207905.
KEGGi cbu:CBU_0043.
PATRICi 17928763. VBICoxBur82552_0044.

Phylogenomic databases

eggNOGi COG0127.
HOGENOMi HOG000293319.
KOi K02428.
OMAi RQAKFVS.
OrthoDBi EOG6CZQQP.

Enzyme and pathway databases

BioCyci CBUR227377:GJ7S-47-MONOMER.

Family and domain databases

Gene3Di 3.90.950.10. 1 hit.
HAMAPi MF_01405. Non_canon_purine_NTPase.
InterProi IPR002637. Ham1p-like.
IPR029001. ITPase-like_fam.
IPR020922. NTPase.
[Graphical view ]
PANTHERi PTHR11067. PTHR11067. 1 hit.
Pfami PF01725. Ham1p_like. 1 hit.
[Graphical view ]
SUPFAMi SSF52972. SSF52972. 1 hit.
TIGRFAMsi TIGR00042. TIGR00042. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiNTPA_COXBU
AccessioniPrimary (citable) accession number: Q83FA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2003
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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