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Q83FA3

- NTPA_COXBU

UniProt

Q83FA3 - NTPA_COXBU

Protein

Non-canonical purine NTP pyrophosphatase

Gene

CBU_0043

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions.UniRule annotation

    Catalytic activityi

    A nucleoside triphosphate + H2O = a nucleotide + diphosphate.UniRule annotation

    Cofactori

    Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi40 – 401Magnesium or manganeseUniRule annotation
    Metal bindingi69 – 691Magnesium or manganeseUniRule annotation
    Binding sitei157 – 1571SubstrateUniRule annotation
    Binding sitei177 – 1771SubstrateUniRule annotation
    Binding sitei183 – 1831SubstrateUniRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. nucleoside-triphosphatase activity Source: InterPro
    3. nucleoside-triphosphate diphosphatase activity Source: UniProtKB-HAMAP
    4. nucleotide binding Source: UniProtKB-KW

    GO - Biological processi

    1. nucleoside triphosphate catabolic process Source: InterPro
    2. purine nucleotide metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCBUR227377:GJ7S-47-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Non-canonical purine NTP pyrophosphataseUniRule annotation (EC:3.6.1.19UniRule annotation)
    Alternative name(s):
    Non-standard purine NTP pyrophosphataseUniRule annotation
    Nucleoside-triphosphate diphosphataseUniRule annotation
    Nucleoside-triphosphate pyrophosphataseUniRule annotation
    Short name:
    NTPaseUniRule annotation
    Gene namesi
    Ordered Locus Names:CBU_0043
    OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
    Taxonomic identifieri227377 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
    ProteomesiUP000002671: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 200200Non-canonical purine NTP pyrophosphatasePRO_0000178160Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi227377.CBU_0043.

    Structurei

    Secondary structure

    1
    200
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi2 – 65
    Helixi11 – 2010
    Turni21 – 233
    Beta strandi24 – 307
    Helixi31 – 344
    Helixi46 – 6116
    Beta strandi65 – 7410
    Helixi75 – 773
    Helixi82 – 843
    Turni85 – 895
    Helixi95 – 10915
    Beta strandi115 – 12713
    Beta strandi134 – 14411
    Beta strandi151 – 1533
    Helixi157 – 1593
    Turni163 – 1653
    Beta strandi166 – 1683
    Turni169 – 1713
    Helixi174 – 1807
    Helixi182 – 19615

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3TQUX-ray1.90A/B/C/D1-200[»]
    ProteinModelPortaliQ83FA3.
    SMRiQ83FA3. Positions 1-195.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni8 – 136Substrate bindingUniRule annotation
    Regioni69 – 702Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the HAM1 NTPase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0127.
    HOGENOMiHOG000293319.
    KOiK02428.
    OMAiRQAKFVS.
    OrthoDBiEOG6CZQQP.

    Family and domain databases

    Gene3Di3.90.950.10. 1 hit.
    HAMAPiMF_01405. Non_canon_purine_NTPase.
    InterProiIPR002637. Ham1p-like.
    IPR029001. ITPase-like_fam.
    IPR020922. NTPase.
    [Graphical view]
    PANTHERiPTHR11067. PTHR11067. 1 hit.
    PfamiPF01725. Ham1p_like. 1 hit.
    [Graphical view]
    SUPFAMiSSF52972. SSF52972. 1 hit.
    TIGRFAMsiTIGR00042. TIGR00042. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q83FA3-1 [UniParc]FASTAAdd to Basket

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    MLEIVLASQN SSKLAEMQEL LRDLEIKFIP QTEFSVPDIE ETGSTFVENA    50
    IIKARHAAKQ TGLPALADDS GLTIAALNSA PGVFSSRYAG KNATDAERIQ 100
    KVLEALEAAD DSDRSASFHC VIALMENEND PAPLICHGVW EGEIAREPRG 150
    KNGFGYDPIF YVPSHQRTAA ELDPQEKNAI SHRGQALEQL STVLTEAFLV 200
    Length:200
    Mass (Da):21,777
    Last modified:June 1, 2003 - v1
    Checksum:iA35DF16EE7025113
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO89612.1.
    RefSeqiNP_819098.1. NC_002971.3.

    Genome annotation databases

    EnsemblBacteriaiAAO89612; AAO89612; CBU_0043.
    GeneIDi1207905.
    KEGGicbu:CBU_0043.
    PATRICi17928763. VBICoxBur82552_0044.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO89612.1 .
    RefSeqi NP_819098.1. NC_002971.3.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3TQU X-ray 1.90 A/B/C/D 1-200 [» ]
    ProteinModelPortali Q83FA3.
    SMRi Q83FA3. Positions 1-195.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 227377.CBU_0043.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO89612 ; AAO89612 ; CBU_0043 .
    GeneIDi 1207905.
    KEGGi cbu:CBU_0043.
    PATRICi 17928763. VBICoxBur82552_0044.

    Phylogenomic databases

    eggNOGi COG0127.
    HOGENOMi HOG000293319.
    KOi K02428.
    OMAi RQAKFVS.
    OrthoDBi EOG6CZQQP.

    Enzyme and pathway databases

    BioCyci CBUR227377:GJ7S-47-MONOMER.

    Family and domain databases

    Gene3Di 3.90.950.10. 1 hit.
    HAMAPi MF_01405. Non_canon_purine_NTPase.
    InterProi IPR002637. Ham1p-like.
    IPR029001. ITPase-like_fam.
    IPR020922. NTPase.
    [Graphical view ]
    PANTHERi PTHR11067. PTHR11067. 1 hit.
    Pfami PF01725. Ham1p_like. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52972. SSF52972. 1 hit.
    TIGRFAMsi TIGR00042. TIGR00042. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RSA 493 / Nine Mile phase I.

    Entry informationi

    Entry nameiNTPA_COXBU
    AccessioniPrimary (citable) accession number: Q83FA3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Coxiella burnetii
      Coxiella burnetii (strain RSA 493): entries and gene names
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3