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Q83FA3 (NTPA_COXBU) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Non-canonical purine NTP pyrophosphatase

EC=3.6.1.19
Alternative name(s):
Non-standard purine NTP pyrophosphatase
Nucleoside-triphosphate diphosphatase
Nucleoside-triphosphate pyrophosphatase
Short name=NTPase
Gene names
Ordered Locus Names:CBU_0043
OrganismCoxiella burnetii (strain RSA 493 / Nine Mile phase I) [Reference proteome] [HAMAP]
Taxonomic identifier227377 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella

Protein attributes

Sequence length200 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions By similarity. HAMAP-Rule MF_01405

Catalytic activity

A nucleoside triphosphate + H2O = a nucleotide + diphosphate. HAMAP-Rule MF_01405

Cofactor

Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity.

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01405

Sequence similarities

Belongs to the HAM1 NTPase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 200200Non-canonical purine NTP pyrophosphatase HAMAP-Rule MF_01405
PRO_0000178160

Regions

Region8 – 136Substrate binding By similarity
Region69 – 702Substrate binding By similarity

Sites

Metal binding401Magnesium or manganese By similarity
Metal binding691Magnesium or manganese By similarity
Binding site1571Substrate By similarity
Binding site1771Substrate By similarity
Binding site1831Substrate By similarity

Secondary structure

.................................. 200
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q83FA3 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: A35DF16EE7025113

FASTA20021,777
        10         20         30         40         50         60 
MLEIVLASQN SSKLAEMQEL LRDLEIKFIP QTEFSVPDIE ETGSTFVENA IIKARHAAKQ 

        70         80         90        100        110        120 
TGLPALADDS GLTIAALNSA PGVFSSRYAG KNATDAERIQ KVLEALEAAD DSDRSASFHC 

       130        140        150        160        170        180 
VIALMENEND PAPLICHGVW EGEIAREPRG KNGFGYDPIF YVPSHQRTAA ELDPQEKNAI 

       190        200 
SHRGQALEQL STVLTEAFLV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016828 Genomic DNA. Translation: AAO89612.1.
RefSeqNP_819098.1. NC_002971.3.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3TQUX-ray1.90A/B/C/D1-200[»]
ProteinModelPortalQ83FA3.
SMRQ83FA3. Positions 1-195.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING227377.CBU_0043.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO89612; AAO89612; CBU_0043.
GeneID1207905.
KEGGcbu:CBU_0043.
PATRIC17928763. VBICoxBur82552_0044.

Phylogenomic databases

eggNOGCOG0127.
HOGENOMHOG000293319.
KOK02428.
OMARQAKFVS.
OrthoDBEOG6CZQQP.

Enzyme and pathway databases

BioCycCBUR227377:GJ7S-47-MONOMER.

Family and domain databases

Gene3D3.90.950.10. 1 hit.
HAMAPMF_01405. Non_canon_purine_NTPase.
InterProIPR002637. Ham1p-like.
IPR029001. ITPase-like_fam.
IPR020922. NTPase.
[Graphical view]
PANTHERPTHR11067. PTHR11067. 1 hit.
PfamPF01725. Ham1p_like. 1 hit.
[Graphical view]
SUPFAMSSF52972. SSF52972. 1 hit.
TIGRFAMsTIGR00042. TIGR00042. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNTPA_COXBU
AccessionPrimary (citable) accession number: Q83FA3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2003
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Coxiella burnetii

Coxiella burnetii (strain RSA 493): entries and gene names