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Q83FA3

- NTPA_COXBU

UniProt

Q83FA3 - NTPA_COXBU

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Protein

Non-canonical purine NTP pyrophosphatase

Gene

CBU_0043

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions.UniRule annotation

Catalytic activityi

A nucleoside triphosphate + H2O = a nucleotide + diphosphate.UniRule annotation

Cofactori

Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi40 – 401Magnesium or manganeseUniRule annotation
Metal bindingi69 – 691Magnesium or manganeseUniRule annotation
Binding sitei157 – 1571SubstrateUniRule annotation
Binding sitei177 – 1771SubstrateUniRule annotation
Binding sitei183 – 1831SubstrateUniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. nucleoside-triphosphatase activity Source: InterPro
  3. nucleoside-triphosphate diphosphatase activity Source: UniProtKB-HAMAP
  4. nucleotide binding Source: UniProtKB-KW

GO - Biological processi

  1. nucleoside triphosphate catabolic process Source: InterPro
  2. purine nucleotide metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-47-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Non-canonical purine NTP pyrophosphataseUniRule annotation (EC:3.6.1.19UniRule annotation)
Alternative name(s):
Non-standard purine NTP pyrophosphataseUniRule annotation
Nucleoside-triphosphate diphosphataseUniRule annotation
Nucleoside-triphosphate pyrophosphataseUniRule annotation
Short name:
NTPaseUniRule annotation
Gene namesi
Ordered Locus Names:CBU_0043
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 200200Non-canonical purine NTP pyrophosphatasePRO_0000178160Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi227377.CBU_0043.

Structurei

Secondary structure

1
200
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 65
Helixi11 – 2010
Turni21 – 233
Beta strandi24 – 307
Helixi31 – 344
Helixi46 – 6116
Beta strandi65 – 7410
Helixi75 – 773
Helixi82 – 843
Turni85 – 895
Helixi95 – 10915
Beta strandi115 – 12713
Beta strandi134 – 14411
Beta strandi151 – 1533
Helixi157 – 1593
Turni163 – 1653
Beta strandi166 – 1683
Turni169 – 1713
Helixi174 – 1807
Helixi182 – 19615

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3TQUX-ray1.90A/B/C/D1-200[»]
ProteinModelPortaliQ83FA3.
SMRiQ83FA3. Positions 1-195.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni8 – 136Substrate bindingUniRule annotation
Regioni69 – 702Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the HAM1 NTPase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0127.
HOGENOMiHOG000293319.
KOiK02428.
OMAiRQAKFVS.
OrthoDBiEOG6CZQQP.

Family and domain databases

Gene3Di3.90.950.10. 1 hit.
HAMAPiMF_01405. Non_canon_purine_NTPase.
InterProiIPR002637. Ham1p-like.
IPR029001. ITPase-like_fam.
IPR020922. NTPase.
[Graphical view]
PANTHERiPTHR11067. PTHR11067. 1 hit.
PfamiPF01725. Ham1p_like. 1 hit.
[Graphical view]
SUPFAMiSSF52972. SSF52972. 1 hit.
TIGRFAMsiTIGR00042. TIGR00042. 1 hit.

Sequencei

Sequence statusi: Complete.

Q83FA3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLEIVLASQN SSKLAEMQEL LRDLEIKFIP QTEFSVPDIE ETGSTFVENA
60 70 80 90 100
IIKARHAAKQ TGLPALADDS GLTIAALNSA PGVFSSRYAG KNATDAERIQ
110 120 130 140 150
KVLEALEAAD DSDRSASFHC VIALMENEND PAPLICHGVW EGEIAREPRG
160 170 180 190 200
KNGFGYDPIF YVPSHQRTAA ELDPQEKNAI SHRGQALEQL STVLTEAFLV
Length:200
Mass (Da):21,777
Last modified:June 1, 2003 - v1
Checksum:iA35DF16EE7025113
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016828 Genomic DNA. Translation: AAO89612.1.
RefSeqiNP_819098.1. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO89612; AAO89612; CBU_0043.
GeneIDi1207905.
KEGGicbu:CBU_0043.
PATRICi17928763. VBICoxBur82552_0044.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016828 Genomic DNA. Translation: AAO89612.1 .
RefSeqi NP_819098.1. NC_002971.3.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3TQU X-ray 1.90 A/B/C/D 1-200 [» ]
ProteinModelPortali Q83FA3.
SMRi Q83FA3. Positions 1-195.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227377.CBU_0043.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO89612 ; AAO89612 ; CBU_0043 .
GeneIDi 1207905.
KEGGi cbu:CBU_0043.
PATRICi 17928763. VBICoxBur82552_0044.

Phylogenomic databases

eggNOGi COG0127.
HOGENOMi HOG000293319.
KOi K02428.
OMAi RQAKFVS.
OrthoDBi EOG6CZQQP.

Enzyme and pathway databases

BioCyci CBUR227377:GJ7S-47-MONOMER.

Family and domain databases

Gene3Di 3.90.950.10. 1 hit.
HAMAPi MF_01405. Non_canon_purine_NTPase.
InterProi IPR002637. Ham1p-like.
IPR029001. ITPase-like_fam.
IPR020922. NTPase.
[Graphical view ]
PANTHERi PTHR11067. PTHR11067. 1 hit.
Pfami PF01725. Ham1p_like. 1 hit.
[Graphical view ]
SUPFAMi SSF52972. SSF52972. 1 hit.
TIGRFAMsi TIGR00042. TIGR00042. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiNTPA_COXBU
AccessioniPrimary (citable) accession number: Q83FA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2003
Last modified: October 1, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3