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Protein

Probable chorismate pyruvate-lyase

Gene

ubiC

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.UniRule annotation

Catalytic activityi

Chorismate = 4-hydroxybenzoate + pyruvate.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei75SubstrateUniRule annotation1
Binding sitei113Substrate; via amide nitrogenUniRule annotation1
Binding sitei170SubstrateUniRule annotation1

GO - Molecular functioni

  • chorismate lyase activity Source: TIGR

GO - Biological processi

  • pyruvate biosynthetic process Source: UniProtKB-HAMAP
  • ubiquinone biosynthetic process Source: TIGR
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Ubiquinone biosynthesis

Keywords - Ligandi

Pyruvate

Enzyme and pathway databases

UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable chorismate pyruvate-lyaseUniRule annotation (EC:4.1.3.40UniRule annotation)
Short name:
CLUniRule annotation
Short name:
CPLUniRule annotation
Gene namesi
Name:ubiCUniRule annotation
Ordered Locus Names:CBU_0054
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
Proteomesi
  • UP000002671 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002405441 – 185Probable chorismate pyruvate-lyaseAdd BLAST185

Interactioni

Protein-protein interaction databases

STRINGi227377.CBU_0054.

Structurei

3D structure databases

ProteinModelPortaliQ83F94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UbiC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410807V. Bacteria.
COG3161. LUCA.
HOGENOMiHOG000027323.
KOiK03181.
OMAiEVCHYPE.

Family and domain databases

Gene3Di3.40.1410.10. 1 hit.
HAMAPiMF_01632. UbiC. 1 hit.
InterProiIPR007440. Chorismate--pyruvate_lyase.
IPR028978. Chorismate_lyase_/UTRA_dom.
[Graphical view]
PfamiPF04345. Chor_lyase. 1 hit.
[Graphical view]
SUPFAMiSSF64288. SSF64288. 1 hit.

Sequencei

Sequence statusi: Complete.

Q83F94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKQLFWAPQ NEIPSTLWTA NERSWLTHPG SLTQRLRKTT DGQIQHHLLR
60 70 80 90 100
EVFDAPVDEE TQLLGISQPE LALIREIEWR YFESLWVAGR VVIPKKTLER
110 120 130 140 150
EGSPLNHIGE RSLGDILFAN AKFTRGDLEF RQITADHPYY FYVKEIANGS
160 170 180
CIWARRSLFY FERDPLLVSE IFSPALFLES SVSND
Length:185
Mass (Da):21,536
Last modified:June 1, 2003 - v1
Checksum:i092F5FED72D6C720
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO89621.1.
RefSeqiNP_819107.1. NC_002971.3.
WP_010957348.1. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO89621; AAO89621; CBU_0054.
GeneIDi1207916.
KEGGicbu:CBU_0054.
PATRICi17928787. VBICoxBur82552_0056.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO89621.1.
RefSeqiNP_819107.1. NC_002971.3.
WP_010957348.1. NC_002971.3.

3D structure databases

ProteinModelPortaliQ83F94.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi227377.CBU_0054.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO89621; AAO89621; CBU_0054.
GeneIDi1207916.
KEGGicbu:CBU_0054.
PATRICi17928787. VBICoxBur82552_0056.

Phylogenomic databases

eggNOGiENOG410807V. Bacteria.
COG3161. LUCA.
HOGENOMiHOG000027323.
KOiK03181.
OMAiEVCHYPE.

Enzyme and pathway databases

UniPathwayiUPA00232.

Family and domain databases

Gene3Di3.40.1410.10. 1 hit.
HAMAPiMF_01632. UbiC. 1 hit.
InterProiIPR007440. Chorismate--pyruvate_lyase.
IPR028978. Chorismate_lyase_/UTRA_dom.
[Graphical view]
PfamiPF04345. Chor_lyase. 1 hit.
[Graphical view]
SUPFAMiSSF64288. SSF64288. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUBIC_COXBU
AccessioniPrimary (citable) accession number: Q83F94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.