Q83F93 (UBIA_COXBU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
4-hydroxybenzoate octaprenyltransferase
EC=2.5.1.-

Alternative name(s):
4-HB polyprenyltransferase

Gene names

Name:	ubiA
Ordered Locus Names:	CBU_0055

Organism

Coxiella burnetii

Taxonomic identifier

777 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella

Protein attributes

Sequence length	287 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Synthesis of 3-octaprenyl-4-hydroxybenzoate By similarity. HAMAP MF_01635
Catalytic activity	4-hydroxybenzoate + farnesylfarnesylgeraniol = 3-octaprenyl-4-hydroxybenzoate. HAMAP MF_01635
Cofactor	Magnesium By similarity. HAMAP MF_01635
Pathway	Cofactor biosynthesis; ubiquinone biosynthesis. HAMAP MF_01635
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_01635.
Sequence similarities	Belongs to the UbiA prenyltransferase family.

Ontologies

Keywords
Biological process	Ubiquinone biosynthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Magnesium
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ubiquinone biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	prenyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 287	287	4-hydroxybenzoate octaprenyltransferase HAMAP MF_01635		PRO_0000262790
Regions
	Transmembrane	21 – 41	21	Helical; Potential
	Transmembrane	44 – 64	21	Helical; Potential
	Transmembrane	91 – 111	21	Helical; Potential
	Transmembrane	112 – 132	21	Helical; Potential
	Transmembrane	139 – 159	21	Helical; Potential
	Transmembrane	160 – 180	21	Helical; Potential
	Transmembrane	211 – 231	21	Helical; Potential
	Transmembrane	235 – 255	21	Helical; Potential
	Transmembrane	263 – 283	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q83F93 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 60CF7C03E73D1C45	FASTA	287	32,738
	10 20 30 40 50 60 MINLRQQMPH YLRLMRFDKP VGIFLLLWPT LWAVWIAAKG APSFKIAVIF IAGSVVMRAA 70 80 90 100 110 120 GCIVNDFADR HLDKHVQRTQ MRPLASGSVS VTEAMLLFAV LSLIAFTLVL LLNRLTVELA 130 140 150 160 170 180 VIGILLALVY PFLKRFTHLP QLWLGVAFSW SIPMAFAATV GHVPAVAWLL FFAAVLWPIV 190 200 210 220 230 240 YDTQYAMIDR EDDVKVGIKS TAILFGRYDR LMIGLLQGSV LLTFGLLGWY LRFNYWFYLG 250 260 270 280 LLVALGLMCY QQFLIRHRKP PDCFAAFRNN NWVGFFIFLG ILLTYRN

References

[1]

"Complete genome sequence of the Q-fever pathogen, Coxiella burnetii." Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A. , Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E., Fraser C.M., Heidelberg J.F. Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed: 12704232] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nine Mile phase I / RSA 493.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016828 Genomic DNA. Translation: AAO89622.1.
RefSeq	NP_819108.1. NC_002971.3.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q83F93.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1207917.
GenomeReviews	Gene locus CBU_0055 in contig AE016828_GR.
KEGG	cbu:CBU_0055.
NMPDR	fig|227377.1.peg.52.
PATRIC	17928789. VBICoxBur82552_0057.
TIGR	CBU_0055.
Phylogenomic databases
HOGENOM	HBG324383.
OMA	VLIPWAA.
PhylomeDB	Q83F93.
ProtClustDB	CLSK913801.
Enzyme and pathway databases
BioCyc	CBUR227377:CBU_0055-MONOMER.
Family and domain databases
HAMAP	MF_01635. UbiA. [Tree]
InterPro	IPR006370. HB_polyprenyl-transferase. IPR000537. UbiA_prenyltransferase. [Graphical view]
KO	K03179.
Pfam	PF01040. UbiA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01474. UbiA_proteo. 1 hit.
PROSITE	PS00943. UBIA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UBIA_COXBU

Accession

Primary (citable) accession number: Q83F93

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program