Reviewed, UniProtKB/Swiss-Prot Q83F59 (TOLB_COXBU)

Names and origin

Protein names

Recommended name:
    Protein tolB

Gene names

Name:	tolB
Ordered Locus Names:	CBU_0090

Organism

Coxiella burnetii [Complete proteome] [HAMAP]

Taxonomic identifier

777 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella

Protein attributes

Sequence length	437 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in the tonB-independent uptake of proteins By similarity.
Subcellular location	Periplasm Potential.
Developmental stage	More than twofold more abundant in the small cell variant (SCV) stage than in the large cell variant (LCV) stage (at protein level). LCVs are more metabolically active than SCVs. Ref.2
Sequence similarities	Belongs to the tolB family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Periplasm
Domain	Signal
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein import Inferred from electronic annotation. Source: HAMAP proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	membrane Inferred from electronic annotation. Source: InterPro periplasmic space Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 437	413	Protein tolB HAMAP MF_00671		PRO_0000034644

Sequences

	Sequence		Length	Mass (Da)
	Q83F59-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 587C4231E41133D0	FASTA	437	47,792
	10 20 30 40 50 60 MQKRHPIIYL LITLLIFVPV SYGALDLELT KGVTAAIPIA IMPFAGPSVL APGDETIPQV 70 80 90 100 110 120 IKNDLQNSGQ FRVTGSGNLD QTAASLEQID YSYWRKQKVN ALVVGAINPL GMRRYRVAFT 130 140 150 160 170 180 LINVFDSNNR LLSESFNVNA KELRNLAHHI SDLIYQKLTG VRGVFSTKIA YVLVQASSEN 190 200 210 220 230 240 TAAKYTLEVA DADGFNPQPL LVSDMPIMSP TWSPDGNKIA YVSFEGHRAA IYLQDLATGR 250 260 270 280 290 300 RQRLSEAPGI NGAPAFSPDG KQLALVLTKT GNPKIYILNL ADGHLREITK GWSIDTEPAW 310 320 330 340 350 360 SPDGKSLLFT SNRDGTPQIY NYSFADGSIN RVTYRGDYNA RPSFMPDGKS IIMMHRENGL 370 380 390 400 410 420 FGIARQDLST GQVQILSESG TDESPSLAPN GKMAIYAMEY GGRGVLAQVS IDGQIKLRLP 430 ARNGNVQEPA WSPYLGV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of the Q-fever pathogen, Coxiella burnetii." Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A. , Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E., Fraser C.M., Heidelberg J.F. Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed: 12704232] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nine Mile phase I / RSA 493.
[2]	"Proteome and antigen profiling of Coxiella burnetii developmental forms." Coleman S.A., Fischer E.R., Cockrell D.C., Voth D.E., Howe D., Mead D.J., Samuel J.E., Heinzen R.A. Infect. Immun. 75:290-298(2007) [PubMed: 17088354] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, DEVELOPMENTAL STAGE. Strain: Nine Mile Crazy / RSA 514.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016828 Genomic DNA. Translation: AAO89656.2. Different initiation.
RefSeq	NP_819142.2.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1207960.
GenomeReviews	Gene locus CBU_0090 in contig AE016828_GR.
KEGG	cbu:CBU_0090.
NMPDR	fig|227377.1.peg.86.
TIGR	CBU_0090.
Phylogenomic databases
HOGENOM	Q83F59.
OMA	VREPSWG
Enzyme and pathway databases
BioCyc	CBUR227377:CBU_0090-MON.
Family and domain databases
HAMAP	MF_00671. [Tree]
InterPro	IPR011042. 6-blade_b-propeller_TolB-like. IPR011659. PD40. IPR002469. Peptidase_S9B. IPR014167. Tol-Pal_propeller_TolB. IPR007195. TolB_N. [Graphical view]
Gene3D	G3DSA:2.120.10.30. 6-blade_b-propeller_TolB-like. 1 hit. G3DSA:3.40.50.10070. TolB_N. 1 hit.
Pfam	PF00930. DPPIV_N. 1 hit. PF07676. PD40. 2 hits. PF04052. TolB_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR02800. propeller_TolB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TOLB_COXBU

Accession

Primary (citable) accession number: Q83F59

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2003
Last sequence update:	June 1, 2003
Last modified:	November 24, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)