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Q83F16

- MURB_COXBU

UniProt

Q83F16 - MURB_COXBU

Protein

UDP-N-acetylenolpyruvoylglucosamine reductase

Gene

murB

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Cell wall formation.UniRule annotation

    Catalytic activityi

    UDP-N-acetyl-alpha-D-muramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH.UniRule annotation

    Cofactori

    FAD.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei190 – 1901UniRule annotation
    Active sitei239 – 2391Proton donorUniRule annotation
    Active sitei309 – 3091UniRule annotation

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: InterPro
    2. UDP-N-acetylmuramate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
    4. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Keywords - Ligandi

    FAD, Flavoprotein, NADP

    Enzyme and pathway databases

    BioCyciCBUR227377:GJ7S-139-MONOMER.
    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-N-acetylenolpyruvoylglucosamine reductaseUniRule annotation (EC:1.3.1.98UniRule annotation)
    Alternative name(s):
    UDP-N-acetylmuramate dehydrogenaseUniRule annotation
    Gene namesi
    Name:murBUniRule annotation
    Ordered Locus Names:CBU_0137
    OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
    Taxonomic identifieri227377 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
    ProteomesiUP000002671: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 316316UDP-N-acetylenolpyruvoylglucosamine reductasePRO_0000179205Add
    BLAST

    Proteomic databases

    PRIDEiQ83F16.

    Interactioni

    Protein-protein interaction databases

    STRINGi227377.CBU_0137.

    Structurei

    3D structure databases

    ProteinModelPortaliQ83F16.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini27 – 225199FAD-binding PCMH-typeUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the MurB family.UniRule annotation
    Contains 1 FAD-binding PCMH-type domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0812.
    HOGENOMiHOG000284355.
    KOiK00075.
    OMAiFAGKLIM.
    OrthoDBiEOG60CWQ3.

    Family and domain databases

    Gene3Di3.30.43.10. 1 hit.
    3.30.465.10. 1 hit.
    3.90.78.10. 1 hit.
    HAMAPiMF_00037. MurB.
    InterProiIPR016169. CO_DH_flavot_FAD-bd_sub2.
    IPR016166. FAD-bd_2.
    IPR016167. FAD-bd_2_sub1.
    IPR003170. MurB.
    IPR011601. MurB_C.
    IPR006094. Oxid_FAD_bind_N.
    [Graphical view]
    PANTHERiPTHR21071. PTHR21071. 1 hit.
    PfamiPF01565. FAD_binding_4. 1 hit.
    PF02873. MurB_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF56176. SSF56176. 1 hit.
    SSF56194. SSF56194. 1 hit.
    TIGRFAMsiTIGR00179. murB. 1 hit.
    PROSITEiPS51387. FAD_PCMH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q83F16-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDKENFTRLR GELFCDHPLA RYTSWRVGGK AERFYRPADL FDLQDFLTQL    50
    PSDEPLTWLG LGSNVLIRDG GIKGTVILTL NRLKELSVVN SQLVFREKSG 100
    TEDFFSGNGK TIIRAEAGVT CAKLAKFCVS QGLEDGAFFA GIPGTVGGAL 150
    AMNAGAFGGE TWRTVIGVET MNHQGEILKR TPDEFKIHYR QVEGLENQFF 200
    IAGYFCFNHG DPDKAKTAIN ALLKKRNLSQ PIGKYSCGSV FRNPPGDYAA 250
    RLIESAGLKG KSIGNAEVSE KHANFILNKG NASAADIEAL IHYVAQHVSQ 300
    IHGIQLVKEV HIIGRS 316
    Length:316
    Mass (Da):34,632
    Last modified:June 1, 2003 - v1
    Checksum:i645EEF641A099AB6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO89701.1.
    RefSeqiNP_819187.1. NC_002971.3.

    Genome annotation databases

    EnsemblBacteriaiAAO89701; AAO89701; CBU_0137.
    GeneIDi1208008.
    KEGGicbu:CBU_0137.
    PATRICi17928957. VBICoxBur82552_0139.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO89701.1 .
    RefSeqi NP_819187.1. NC_002971.3.

    3D structure databases

    ProteinModelPortali Q83F16.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 227377.CBU_0137.

    Proteomic databases

    PRIDEi Q83F16.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO89701 ; AAO89701 ; CBU_0137 .
    GeneIDi 1208008.
    KEGGi cbu:CBU_0137.
    PATRICi 17928957. VBICoxBur82552_0139.

    Phylogenomic databases

    eggNOGi COG0812.
    HOGENOMi HOG000284355.
    KOi K00075.
    OMAi FAGKLIM.
    OrthoDBi EOG60CWQ3.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci CBUR227377:GJ7S-139-MONOMER.

    Family and domain databases

    Gene3Di 3.30.43.10. 1 hit.
    3.30.465.10. 1 hit.
    3.90.78.10. 1 hit.
    HAMAPi MF_00037. MurB.
    InterProi IPR016169. CO_DH_flavot_FAD-bd_sub2.
    IPR016166. FAD-bd_2.
    IPR016167. FAD-bd_2_sub1.
    IPR003170. MurB.
    IPR011601. MurB_C.
    IPR006094. Oxid_FAD_bind_N.
    [Graphical view ]
    PANTHERi PTHR21071. PTHR21071. 1 hit.
    Pfami PF01565. FAD_binding_4. 1 hit.
    PF02873. MurB_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56176. SSF56176. 1 hit.
    SSF56194. SSF56194. 1 hit.
    TIGRFAMsi TIGR00179. murB. 1 hit.
    PROSITEi PS51387. FAD_PCMH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RSA 493 / Nine Mile phase I.

    Entry informationi

    Entry nameiMURB_COXBU
    AccessioniPrimary (citable) accession number: Q83F16
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Coxiella burnetii
      Coxiella burnetii (strain RSA 493): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3