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Protein

UDP-N-acetylenolpyruvoylglucosamine reductase

Gene

murB

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotation

Catalytic activityi

UDP-N-acetyl-alpha-D-muramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei190UniRule annotation1
Active sitei239Proton donorUniRule annotation1
Active sitei309UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandFAD, Flavoprotein, NADP

Enzyme and pathway databases

BioCyciCBUR227377:G1G0B-139-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylenolpyruvoylglucosamine reductaseUniRule annotation (EC:1.3.1.98UniRule annotation)
Alternative name(s):
UDP-N-acetylmuramate dehydrogenaseUniRule annotation
Gene namesi
Name:murBUniRule annotation
Ordered Locus Names:CBU_0137
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
Proteomesi
  • UP000002671 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001792051 – 316UDP-N-acetylenolpyruvoylglucosamine reductaseAdd BLAST316

Proteomic databases

PRIDEiQ83F16

Interactioni

Protein-protein interaction databases

STRINGi227377.CBU_0137

Structurei

3D structure databases

ProteinModelPortaliQ83F16
SMRiQ83F16
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 225FAD-binding PCMH-typeUniRule annotationAdd BLAST199

Sequence similaritiesi

Belongs to the MurB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D4A Bacteria
COG0812 LUCA
HOGENOMiHOG000284355
KOiK00075
OMAiKMNAGMK

Family and domain databases

Gene3Di3.30.43.10, 1 hit
3.90.78.10, 1 hit
HAMAPiMF_00037 MurB, 1 hit
InterProiView protein in InterPro
IPR016166 FAD-bd_2
IPR036318 FAD-bd_2-like_sf
IPR016167 FAD-bd_2_sub1
IPR003170 MurB
IPR011601 MurB_C
IPR036635 MurB_C_sf
IPR006094 Oxid_FAD_bind_N
PANTHERiPTHR21071 PTHR21071, 1 hit
PfamiView protein in Pfam
PF01565 FAD_binding_4, 1 hit
PF02873 MurB_C, 1 hit
SUPFAMiSSF56176 SSF56176, 1 hit
SSF56194 SSF56194, 1 hit
TIGRFAMsiTIGR00179 murB, 1 hit
PROSITEiView protein in PROSITE
PS51387 FAD_PCMH, 1 hit

Sequencei

Sequence statusi: Complete.

Q83F16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKENFTRLR GELFCDHPLA RYTSWRVGGK AERFYRPADL FDLQDFLTQL
60 70 80 90 100
PSDEPLTWLG LGSNVLIRDG GIKGTVILTL NRLKELSVVN SQLVFREKSG
110 120 130 140 150
TEDFFSGNGK TIIRAEAGVT CAKLAKFCVS QGLEDGAFFA GIPGTVGGAL
160 170 180 190 200
AMNAGAFGGE TWRTVIGVET MNHQGEILKR TPDEFKIHYR QVEGLENQFF
210 220 230 240 250
IAGYFCFNHG DPDKAKTAIN ALLKKRNLSQ PIGKYSCGSV FRNPPGDYAA
260 270 280 290 300
RLIESAGLKG KSIGNAEVSE KHANFILNKG NASAADIEAL IHYVAQHVSQ
310
IHGIQLVKEV HIIGRS
Length:316
Mass (Da):34,632
Last modified:June 1, 2003 - v1
Checksum:i645EEF641A099AB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA Translation: AAO89701.1
RefSeqiNP_819187.1, NC_002971.3
WP_010957398.1, NZ_LM994641.1

Genome annotation databases

EnsemblBacteriaiAAO89701; AAO89701; CBU_0137
GeneIDi1208008
KEGGicbu:CBU_0137
PATRICifig|227377.7.peg.139

Similar proteinsi

Entry informationi

Entry nameiMURB_COXBU
AccessioniPrimary (citable) accession number: Q83F16
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2003
Last modified: March 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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