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Q83F16

- MURB_COXBU

UniProt

Q83F16 - MURB_COXBU

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Protein

UDP-N-acetylenolpyruvoylglucosamine reductase

Gene
murB, CBU_0137
Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation By similarity.UniRule annotation

Catalytic activityi

UDP-N-acetyl-alpha-D-muramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH.UniRule annotation

Cofactori

FAD By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei190 – 1901 By similarity
Active sitei239 – 2391Proton donor By similarity
Active sitei309 – 3091 By similarity

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: InterPro
  2. UDP-N-acetylmuramate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  4. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Keywords - Ligandi

FAD, Flavoprotein, NADP

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-139-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylenolpyruvoylglucosamine reductase (EC:1.3.1.98)
Alternative name(s):
UDP-N-acetylmuramate dehydrogenase
Gene namesi
Name:murB
Ordered Locus Names:CBU_0137
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316UDP-N-acetylenolpyruvoylglucosamine reductaseUniRule annotationPRO_0000179205Add
BLAST

Proteomic databases

PRIDEiQ83F16.

Interactioni

Protein-protein interaction databases

STRINGi227377.CBU_0137.

Structurei

3D structure databases

ProteinModelPortaliQ83F16.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 225199FAD-binding PCMH-typeAdd
BLAST

Sequence similaritiesi

Belongs to the MurB family.

Phylogenomic databases

eggNOGiCOG0812.
HOGENOMiHOG000284355.
KOiK00075.
OMAiFAGKLIM.
OrthoDBiEOG60CWQ3.

Family and domain databases

Gene3Di3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
3.90.78.10. 1 hit.
HAMAPiMF_00037. MurB.
InterProiIPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR003170. MurB.
IPR011601. MurB_C.
IPR006094. Oxid_FAD_bind_N.
[Graphical view]
PANTHERiPTHR21071. PTHR21071. 1 hit.
PfamiPF01565. FAD_binding_4. 1 hit.
PF02873. MurB_C. 1 hit.
[Graphical view]
SUPFAMiSSF56176. SSF56176. 1 hit.
SSF56194. SSF56194. 1 hit.
TIGRFAMsiTIGR00179. murB. 1 hit.
PROSITEiPS51387. FAD_PCMH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q83F16-1 [UniParc]FASTAAdd to Basket

« Hide

MDKENFTRLR GELFCDHPLA RYTSWRVGGK AERFYRPADL FDLQDFLTQL    50
PSDEPLTWLG LGSNVLIRDG GIKGTVILTL NRLKELSVVN SQLVFREKSG 100
TEDFFSGNGK TIIRAEAGVT CAKLAKFCVS QGLEDGAFFA GIPGTVGGAL 150
AMNAGAFGGE TWRTVIGVET MNHQGEILKR TPDEFKIHYR QVEGLENQFF 200
IAGYFCFNHG DPDKAKTAIN ALLKKRNLSQ PIGKYSCGSV FRNPPGDYAA 250
RLIESAGLKG KSIGNAEVSE KHANFILNKG NASAADIEAL IHYVAQHVSQ 300
IHGIQLVKEV HIIGRS 316
Length:316
Mass (Da):34,632
Last modified:June 1, 2003 - v1
Checksum:i645EEF641A099AB6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016828 Genomic DNA. Translation: AAO89701.1.
RefSeqiNP_819187.1. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO89701; AAO89701; CBU_0137.
GeneIDi1208008.
KEGGicbu:CBU_0137.
PATRICi17928957. VBICoxBur82552_0139.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016828 Genomic DNA. Translation: AAO89701.1 .
RefSeqi NP_819187.1. NC_002971.3.

3D structure databases

ProteinModelPortali Q83F16.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227377.CBU_0137.

Proteomic databases

PRIDEi Q83F16.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO89701 ; AAO89701 ; CBU_0137 .
GeneIDi 1208008.
KEGGi cbu:CBU_0137.
PATRICi 17928957. VBICoxBur82552_0139.

Phylogenomic databases

eggNOGi COG0812.
HOGENOMi HOG000284355.
KOi K00075.
OMAi FAGKLIM.
OrthoDBi EOG60CWQ3.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci CBUR227377:GJ7S-139-MONOMER.

Family and domain databases

Gene3Di 3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
3.90.78.10. 1 hit.
HAMAPi MF_00037. MurB.
InterProi IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR003170. MurB.
IPR011601. MurB_C.
IPR006094. Oxid_FAD_bind_N.
[Graphical view ]
PANTHERi PTHR21071. PTHR21071. 1 hit.
Pfami PF01565. FAD_binding_4. 1 hit.
PF02873. MurB_C. 1 hit.
[Graphical view ]
SUPFAMi SSF56176. SSF56176. 1 hit.
SSF56194. SSF56194. 1 hit.
TIGRFAMsi TIGR00179. murB. 1 hit.
PROSITEi PS51387. FAD_PCMH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiMURB_COXBU
AccessioniPrimary (citable) accession number: Q83F16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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