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Q83F16 (MURB_COXBU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-N-acetylenolpyruvoylglucosamine reductase

EC=1.3.1.98
Alternative name(s):
UDP-N-acetylmuramate dehydrogenase
Gene names
Name:murB
Ordered Locus Names:CBU_0137
OrganismCoxiella burnetii (strain RSA 493 / Nine Mile phase I) [Reference proteome] [HAMAP]
Taxonomic identifier227377 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00037

Catalytic activity

UDP-N-acetyl-alpha-D-muramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH. HAMAP-Rule MF_00037

Cofactor

FAD By similarity. HAMAP-Rule MF_00037

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00037

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00037.

Sequence similarities

Belongs to the MurB family.

Contains 1 FAD-binding PCMH-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 316316UDP-N-acetylenolpyruvoylglucosamine reductase HAMAP-Rule MF_00037
PRO_0000179205

Regions

Domain27 – 225199FAD-binding PCMH-type

Sites

Active site1901 By similarity
Active site2391Proton donor By similarity
Active site3091 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q83F16 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 645EEF641A099AB6

FASTA31634,632
        10         20         30         40         50         60 
MDKENFTRLR GELFCDHPLA RYTSWRVGGK AERFYRPADL FDLQDFLTQL PSDEPLTWLG 

        70         80         90        100        110        120 
LGSNVLIRDG GIKGTVILTL NRLKELSVVN SQLVFREKSG TEDFFSGNGK TIIRAEAGVT 

       130        140        150        160        170        180 
CAKLAKFCVS QGLEDGAFFA GIPGTVGGAL AMNAGAFGGE TWRTVIGVET MNHQGEILKR 

       190        200        210        220        230        240 
TPDEFKIHYR QVEGLENQFF IAGYFCFNHG DPDKAKTAIN ALLKKRNLSQ PIGKYSCGSV 

       250        260        270        280        290        300 
FRNPPGDYAA RLIESAGLKG KSIGNAEVSE KHANFILNKG NASAADIEAL IHYVAQHVSQ 

       310 
IHGIQLVKEV HIIGRS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016828 Genomic DNA. Translation: AAO89701.1.
RefSeqNP_819187.1. NC_002971.3.

3D structure databases

ProteinModelPortalQ83F16.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING227377.CBU_0137.

Proteomic databases

PRIDEQ83F16.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO89701; AAO89701; CBU_0137.
GeneID1208008.
KEGGcbu:CBU_0137.
PATRIC17928957. VBICoxBur82552_0139.

Phylogenomic databases

eggNOGCOG0812.
HOGENOMHOG000284355.
KOK00075.
OMAFAGKLIM.
OrthoDBEOG60CWQ3.

Enzyme and pathway databases

BioCycCBUR227377:GJ7S-139-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
3.90.78.10. 1 hit.
HAMAPMF_00037. MurB.
InterProIPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR003170. MurB.
IPR011601. MurB_C.
IPR006094. Oxid_FAD_bind_N.
[Graphical view]
PANTHERPTHR21071. PTHR21071. 1 hit.
PfamPF01565. FAD_binding_4. 1 hit.
PF02873. MurB_C. 1 hit.
[Graphical view]
SUPFAMSSF56176. SSF56176. 1 hit.
SSF56194. SSF56194. 1 hit.
TIGRFAMsTIGR00179. murB. 1 hit.
PROSITEPS51387. FAD_PCMH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMURB_COXBU
AccessionPrimary (citable) accession number: Q83F16
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Coxiella burnetii

Coxiella burnetii (strain RSA 493): entries and gene names