Cell division protein FtsZ - Coxiella burnetii

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Q83F12 (FTSZ_COXBU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 56. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cell division protein FtsZ

Gene names

Name:	ftsZ
Ordered Locus Names:	CBU_0141

Organism

Coxiella burnetii

Taxonomic identifier

777 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella

Protein attributes

Sequence length	386 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity By similarity. HAMAP MF_00909
Subunit structure	Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner By similarity. Interacts directly with several other division proteins By similarity.
Subcellular location	Cytoplasm By similarity. Note: Assembles at midcell at the inner surface of the cytoplasmic membrane By similarity. HAMAP MF_00909
Developmental stage	More than twofold more abundant in the large cell variant (LCV) stage than in the small cell variant (SCV) stage (at protein level). LCVs are more metabolically active than SCVs. Ref.2
Sequence similarities	Belongs to the FtsZ family.
Sequence caution	The sequence AAO89705.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Cell cycle Cell division Septation
Cellular component	Cytoplasm
Ligand	GTP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	barrier septum assembly Inferred from electronic annotation. Source: UniProtKB-KW cell cycle Inferred from electronic annotation. Source: UniProtKB-KW protein polymerization Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell protein complex Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 386

386

Cell division protein FtsZ HAMAP MF_00909

PRO_0000322125

Regions

Nucleotide binding

104 – 112

GTP Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q83F12 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 81CEDD19FC438291
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FASTA

386

40,746

        10         20         30         40         50         60 
MFELGETSPQ NAQIKVIGIG GGGGNAIEHM IAENIDGVEF VCANTDSQAL GRSNARVVLQ 

        70         80         90        100        110        120 
LGDEITKGLG AGADPSVGRQ AAEEARDRIR EILEGTDMVF LTAGMGGGTG TGAAPIFAEV 

       130        140        150        160        170        180 
AKELGILTVA VVTKPFVFEG KKRMDVAEEG IKALGNYVDS LITIPNNKLL NVLGKNITLL 

       190        200        210        220        230        240 
NAFKAANNVL LGAVQGIADL ITRPGLINVD FADVRTVMSE MGMAMMGTGV SSGENRAREA 

       250        260        270        280        290        300 
AEAAIASPLL EDVDFTGARG VLVNITAGMD LSIGEFEQVG EAVKAFASET ATVVIGTVID 

       310        320        330        340        350        360 
PDMSDELRVT VVVTGLGSHA GGGAGVPLKP VKNTKNDGTL DYHQLDRPTY MRNQEPSKRT 

       370        380 
VDLEEQRDRD FEYLDIPAFL RRLEED

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of the Q-fever pathogen, Coxiella burnetii." Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A. Heidelberg J.F. Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed: 12704232] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nine Mile phase I / RSA 493.
[2]	"Proteome and antigen profiling of Coxiella burnetii developmental forms." Coleman S.A., Fischer E.R., Cockrell D.C., Voth D.E., Howe D., Mead D.J., Samuel J.E., Heinzen R.A. Infect. Immun. 75:290-298(2007) [PubMed: 17088354] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, DEVELOPMENTAL STAGE. Strain: Nine Mile Crazy / RSA 514.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016828 Genomic DNA. Translation: AAO89705.2. Different initiation.
RefSeq	NP_819191.2. NC_002971.3.
3D structure databases
HSSP	HSSP built from PDB template 1OFU based on UniProtKB P47204.
ProteinModelPortal	Q83F12.
SMR	Q83F12. Positions 2-316.
ModBase	Search...
Proteomic databases
PRIDE	Q83F12.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1208012.
GenomeReviews	Gene locus CBU_0141 in contig AE016828_GR.
KEGG	cbu:CBU_0141.
NMPDR	fig\|227377.1.peg.135.
PATRIC	17928965. VBICoxBur82552_0143.
TIGR	CBU_0141.
Phylogenomic databases
HOGENOM	HBG478075.
OMA	KGENRAV.
PhylomeDB	Q83F12.
ProtClustDB	PRK09330.
Enzyme and pathway databases
BioCyc	CBUR227377:CBU_0141-MONOMER.
Family and domain databases
HAMAP	MF_00909. FtsZ. [Tree]
InterPro	IPR000158. Cell_div_FtsZ. IPR020805. Cell_div_FtsZ_CS. IPR024757. FtsZ_C. IPR008280. Tub_FtsZ_C. IPR018316. Tubulin/FtsZ_2-layer-sand-dom. IPR003008. Tubulin_FtsZ_GTPase. [Graphical view]
Gene3D	G3DSA:3.30.1330.20. Tubulin/FtsZ_2-layer-sand-dom. 1 hit. G3DSA:3.40.50.1440. Tubulin_FtsZ. 1 hit.
KO	K03531.
Pfam	PF12327. FtsZ_C. 1 hit. PF00091. Tubulin. 1 hit. [Graphical view]
PRINTS	PR00423. CELLDVISFTSZ.
SMART	SM00864. Tubulin. 1 hit. SM00865. Tubulin_C. 1 hit. [Graphical view]
SUPFAM	SSF55307. Tub_FtsZ_C. 1 hit. SSF52490. Tubulin_FtsZ. 1 hit.
TIGRFAMs	TIGR00065. FtsZ. 1 hit.
PROSITE	PS01134. FTSZ_1. 1 hit. PS01135. FTSZ_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FTSZ_COXBU

Accession

Primary (citable) accession number: Q83F12

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

Coxiella burnetii

Coxiella burnetii (strain RSA 493): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents