Q83F12 (FTSZ_COXBU) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 56.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Cell division protein FtsZ | ||||
| Gene names |
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| Organism | Coxiella burnetii | ||||
| Taxonomic identifier | 777 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella |
Protein attributes
| Sequence length | 386 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity By similarity. HAMAP MF_00909 |
| Subunit structure | Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner By similarity. Interacts directly with several other division proteins By similarity. |
| Subcellular location | Cytoplasm By similarity. Note: Assembles at midcell at the inner surface of the cytoplasmic membrane By similarity. HAMAP MF_00909 |
| Developmental stage | More than twofold more abundant in the large cell variant (LCV) stage than in the small cell variant (SCV) stage (at protein level). LCVs are more metabolically active than SCVs. Ref.2 |
| Sequence similarities | Belongs to the FtsZ family. |
| Sequence caution | The sequence AAO89705.2 differs from that shown. Reason: Erroneous initiation. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cell cycle Cell division Septation |
| Cellular component | Cytoplasm |
| Ligand | GTP-binding Nucleotide-binding |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | barrier septum assembly Inferred from electronic annotation. Source: UniProtKB-KW cell cycleInferred from electronic annotation. Source: UniProtKB-KW protein polymerizationInferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell protein complexInferred from electronic annotation. Source: InterPro |
| Molecular function | GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 386 | 386 | Cell division protein FtsZ HAMAP MF_00909 | PRO_0000322125 | |||||
Regions | |||||||||
| Nucleotide binding | 104 – 112 | 9 | GTP Potential | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Complete genome sequence of the Q-fever pathogen, Coxiella burnetii." Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A. Heidelberg J.F.Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed: 12704232] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nine Mile phase I / RSA 493. |
| [2] | "Proteome and antigen profiling of Coxiella burnetii developmental forms." Coleman S.A., Fischer E.R., Cockrell D.C., Voth D.E., Howe D., Mead D.J., Samuel J.E., Heinzen R.A. Infect. Immun. 75:290-298(2007) [PubMed: 17088354] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, DEVELOPMENTAL STAGE. Strain: Nine Mile Crazy / RSA 514. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE016828 Genomic DNA. Translation: AAO89705.2. Different initiation. |
| RefSeq | NP_819191.2. NC_002971.3. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1OFU based on UniProtKB P47204. |
| ProteinModelPortal | Q83F12. |
| SMR | Q83F12. Positions 2-316. |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | Q83F12. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 1208012. |
| GenomeReviews | Gene locus CBU_0141 in contig AE016828_GR. |
| KEGG | cbu:CBU_0141. |
| NMPDR | fig|227377.1.peg.135. |
| PATRIC | 17928965. VBICoxBur82552_0143. |
| TIGR | CBU_0141. |
Phylogenomic databases | |
| HOGENOM | HBG478075. |
| OMA | KGENRAV. |
| PhylomeDB | Q83F12. |
| ProtClustDB | PRK09330. |
Enzyme and pathway databases | |
| BioCyc | CBUR227377:CBU_0141-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00909. FtsZ. [Tree] |
| InterPro | IPR000158. Cell_div_FtsZ. IPR020805. Cell_div_FtsZ_CS. IPR024757. FtsZ_C. IPR008280. Tub_FtsZ_C. IPR018316. Tubulin/FtsZ_2-layer-sand-dom. IPR003008. Tubulin_FtsZ_GTPase. [Graphical view] |
| Gene3D | G3DSA:3.30.1330.20. Tubulin/FtsZ_2-layer-sand-dom. 1 hit. G3DSA:3.40.50.1440. Tubulin_FtsZ. 1 hit. |
| KO | K03531. |
| Pfam | PF12327. FtsZ_C. 1 hit. PF00091. Tubulin. 1 hit. [Graphical view] |
| PRINTS | PR00423. CELLDVISFTSZ. |
| SMART | SM00864. Tubulin. 1 hit. SM00865. Tubulin_C. 1 hit. [Graphical view] |
| SUPFAM | SSF55307. Tub_FtsZ_C. 1 hit. SSF52490. Tubulin_FtsZ. 1 hit. |
| TIGRFAMs | TIGR00065. FtsZ. 1 hit. |
| PROSITE | PS01134. FTSZ_1. 1 hit. PS01135. FTSZ_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | FTSZ_COXBU | ||||||||
| Accession | Primary (citable) accession number: Q83F12 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Coxiella burnetii Coxiella burnetii (strain RSA 493): entries and gene names |
| SIMILARITY comments Index of protein domains and families |

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