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Reviewed, UniProtKB/Swiss-Prot Q83F12 (FTSZ_COXBU)

Last modified November 24, 2009. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Cell division protein ftsZ
Gene names
Name: ftsZ
Ordered Locus Names: CBU_0141
OrganismCoxiella burnetii [Complete proteome] [HAMAP]
Taxonomic identifier777 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella

Protein attributes

Sequence length386 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

This protein is essential to the cell-division process. It seems to assemble into a dynamic ring on the inner surface of the cytoplasmic membrane at the place where division will occur, and the formation of the ring is the signal for septation to begin. Binds to and hydrolyzes GTP. Involved in the synthesis of the septal peptidoglycan By similarity.

Subunit structure

Aggregates to form a ring-like structure. Interacts with ftsA By similarity.

Subcellular location

Cytoplasm By similarity. Note: Assembles at the inner surface of the cytoplasmic membrane By similarity.

Developmental stage

More than twofold more abundant in the large cell variant (LCV) stage than in the small cell variant (SCV) stage (at protein level). LCVs are more metabolically active than SCVs. Ref.2

Sequence similarities

Belongs to the ftsZ family.

Ontologies

Keywords
   Biological processCell cycle
Cell division
Septation
   Cellular componentCytoplasm
   LigandGTP-binding
Nucleotide-binding
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processbarrier septum formation

Inferred from electronic annotation. Source: UniProtKB-KW

cell cycle

Inferred from electronic annotation. Source: UniProtKB-KW

protein polymerization

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

protein complex

Inferred from electronic annotation. Source: InterPro

   Molecular functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

GTPase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 386386Cell division protein ftsZ
PRO_0000322125

Regions

Nucleotide binding104 – 1129GTP Potential

Sequences

Sequence LengthMass (Da)Tools
Q83F12-1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 81CEDD19FC438291

FASTA38640,746
        10         20         30         40         50         60 
MFELGETSPQ NAQIKVIGIG GGGGNAIEHM IAENIDGVEF VCANTDSQAL GRSNARVVLQ 

        70         80         90        100        110        120 
LGDEITKGLG AGADPSVGRQ AAEEARDRIR EILEGTDMVF LTAGMGGGTG TGAAPIFAEV 

       130        140        150        160        170        180 
AKELGILTVA VVTKPFVFEG KKRMDVAEEG IKALGNYVDS LITIPNNKLL NVLGKNITLL 

       190        200        210        220        230        240 
NAFKAANNVL LGAVQGIADL ITRPGLINVD FADVRTVMSE MGMAMMGTGV SSGENRAREA 

       250        260        270        280        290        300 
AEAAIASPLL EDVDFTGARG VLVNITAGMD LSIGEFEQVG EAVKAFASET ATVVIGTVID 

       310        320        330        340        350        360 
PDMSDELRVT VVVTGLGSHA GGGAGVPLKP VKNTKNDGTL DYHQLDRPTY MRNQEPSKRT 

       370        380 
VDLEEQRDRD FEYLDIPAFL RRLEED 

« Hide

Cross-references

Sequence databases

AE016828 Genomic DNA. Translation: AAO89705.2. Different initiation.
RefSeqNP_819191.2.

3D structure databases

HSSPHSSP built from PDB template 1OFU based on UniProtKB P47204.
SMRQ83F12. Positions 25-317.
ModBaseSearch...

Genome annotation databases

GeneID1208012.
GenomeReviewsGene locus CBU_0141 in contig AE016828_GR.
KEGGcbu:CBU_0141.
NMPDRfig|227377.1.peg.135.
TIGRCBU_0141.

Phylogenomic databases

HOGENOMQ83F12.
OMADVLRMGV

Enzyme and pathway databases

BioCycCBUR227377:CBU_0141-MON.

Family and domain databases

InterProIPR020805. Cell_division_FtsZ_CS.
IPR000158. Cell_division_FtsZ_N.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
IPR019746. Tubulin_FtsZ_N.
[Graphical view]
Gene3DG3DSA:3.30.1330.20. Tubulin/FtsZ_2-layer-sand-dom. 1 hit.
G3DSA:3.40.50.1440. Tubulin_FtsZ. 1 hit.
PfamPF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
[Graphical view]
PRINTSPR00423. CELLDVISFTSZ.
SMARTSM00865. Tubulin_C. 1 hit.
[Graphical view]
TIGRFAMsTIGR00065. ftsZ. 1 hit.
PROSITEPS01134. FTSZ_1. 1 hit.
PS01135. FTSZ_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTSZ_COXBU
AccessionPrimary (citable) accession number: Q83F12
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 1, 2003
Last modified: November 24, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Coxiella burnetii

Coxiella burnetii (strain RSA 493): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents