Reviewed, UniProtKB/Swiss-Prot Q83F12 (FTSZ_COXBU)

Names and origin

Protein names

Recommended name:
    Cell division protein ftsZ

Gene names

Name:	ftsZ
Ordered Locus Names:	CBU_0141

Organism

Coxiella burnetii [Complete proteome] [HAMAP]

Taxonomic identifier

777 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella

Protein attributes

Sequence length	386 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	This protein is essential to the cell-division process. It seems to assemble into a dynamic ring on the inner surface of the cytoplasmic membrane at the place where division will occur, and the formation of the ring is the signal for septation to begin. Binds to and hydrolyzes GTP. Involved in the synthesis of the septal peptidoglycan By similarity.
Subunit structure	Aggregates to form a ring-like structure. Interacts with ftsA By similarity.
Subcellular location	Cytoplasm By similarity. Note: Assembles at the inner surface of the cytoplasmic membrane By similarity.
Developmental stage	More than twofold more abundant in the large cell variant (LCV) stage than in the small cell variant (SCV) stage (at protein level). LCVs are more metabolically active than SCVs. Ref.2
Sequence similarities	Belongs to the ftsZ family.

Ontologies

Keywords
Biological process	Cell cycle Cell division Septation
Cellular component	Cytoplasm
Ligand	GTP-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	barrier septum formation Inferred from electronic annotation. Source: UniProtKB-KW cell cycle Inferred from electronic annotation. Source: UniProtKB-KW protein polymerization Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell protein complex Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 386	386	Cell division protein ftsZ		PRO_0000322125
Regions
	Nucleotide binding	104 – 112	9	GTP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q83F12-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 81CEDD19FC438291	FASTA	386	40,746
	10 20 30 40 50 60 MFELGETSPQ NAQIKVIGIG GGGGNAIEHM IAENIDGVEF VCANTDSQAL GRSNARVVLQ 70 80 90 100 110 120 LGDEITKGLG AGADPSVGRQ AAEEARDRIR EILEGTDMVF LTAGMGGGTG TGAAPIFAEV 130 140 150 160 170 180 AKELGILTVA VVTKPFVFEG KKRMDVAEEG IKALGNYVDS LITIPNNKLL NVLGKNITLL 190 200 210 220 230 240 NAFKAANNVL LGAVQGIADL ITRPGLINVD FADVRTVMSE MGMAMMGTGV SSGENRAREA 250 260 270 280 290 300 AEAAIASPLL EDVDFTGARG VLVNITAGMD LSIGEFEQVG EAVKAFASET ATVVIGTVID 310 320 330 340 350 360 PDMSDELRVT VVVTGLGSHA GGGAGVPLKP VKNTKNDGTL DYHQLDRPTY MRNQEPSKRT 370 380 VDLEEQRDRD FEYLDIPAFL RRLEED

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of the Q-fever pathogen, Coxiella burnetii." Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A. , Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E., Fraser C.M., Heidelberg J.F. Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed: 12704232] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nine Mile phase I / RSA 493.
[2]	"Proteome and antigen profiling of Coxiella burnetii developmental forms." Coleman S.A., Fischer E.R., Cockrell D.C., Voth D.E., Howe D., Mead D.J., Samuel J.E., Heinzen R.A. Infect. Immun. 75:290-298(2007) [PubMed: 17088354] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, DEVELOPMENTAL STAGE. Strain: Nine Mile Crazy / RSA 514.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016828 Genomic DNA. Translation: AAO89705.2. Different initiation.
RefSeq	NP_819191.2.
3D structure databases
HSSP	HSSP built from PDB template 1OFU based on UniProtKB P47204.
SMR	Q83F12. Positions 25-317.
ModBase	Search...
Genome annotation databases
GeneID	1208012.
GenomeReviews	Gene locus CBU_0141 in contig AE016828_GR.
KEGG	cbu:CBU_0141.
NMPDR	fig|227377.1.peg.135.
TIGR	CBU_0141.
Phylogenomic databases
HOGENOM	Q83F12.
OMA	DVLRMGV
Enzyme and pathway databases
BioCyc	CBUR227377:CBU_0141-MON.
Family and domain databases
InterPro	IPR020805. Cell_division_FtsZ_CS. IPR000158. Cell_division_FtsZ_N. IPR008280. Tub_FtsZ_C. IPR018316. Tubulin/FtsZ_2-layer-sand-dom. IPR003008. Tubulin_FtsZ_GTPase. IPR019746. Tubulin_FtsZ_N. [Graphical view]
Gene3D	G3DSA:3.30.1330.20. Tubulin/FtsZ_2-layer-sand-dom. 1 hit. G3DSA:3.40.50.1440. Tubulin_FtsZ. 1 hit.
Pfam	PF00091. Tubulin. 1 hit. PF03953. Tubulin_C. 1 hit. [Graphical view]
PRINTS	PR00423. CELLDVISFTSZ.
SMART	SM00865. Tubulin_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR00065. ftsZ. 1 hit.
PROSITE	PS01134. FTSZ_1. 1 hit. PS01135. FTSZ_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FTSZ_COXBU

Accession

Primary (citable) accession number: Q83F12

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	June 1, 2003
Last modified:	November 24, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)