Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q83F11 (LPXC_COXBU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

EC=3.5.1.-
Alternative name(s):
UDP-3-O-acyl-GlcNAc deacetylase
Gene names
Name:lpxC
Ordered Locus Names:CBU_0142
OrganismCoxiella burnetii (strain RSA 493 / Nine Mile phase I) [Reference proteome] [HAMAP]
Taxonomic identifier227377 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella

Protein attributes

Sequence length303 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00388

Catalytic activity

UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine + H2O = UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine + acetate. HAMAP-Rule MF_00388

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6. HAMAP-Rule MF_00388

Sequence similarities

Belongs to the LpxC family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 303303UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase HAMAP-Rule MF_00388
PRO_0000191928

Sequences

Sequence LengthMass (Da)Tools
Q83F11 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 45B7E1D4D54E49DF

FASTA30333,514
        10         20         30         40         50         60 
MIKQRTLKNV VRATGVGVHT GEKVYLTLRP APPNTGIIFC RTDLDPVVQI PARVNYIGDT 

        70         80         90        100        110        120 
SLSTCLTKGD VRIATVEHLL SALAGVGVDN LYIDLTSPEL PIMDGSAGPF VFLIQSAGIE 

       130        140        150        160        170        180 
EQNAPKEFIR IKQRVKIEEA DKSVMVEPYN GFKISFGIDF DHPLFNEHNQ NATLDFSSTS 

       190        200        210        220        230        240 
YVKEVSRART FGFLSDYEFI RKNNLALGAS LDNALVLDEY KILNQDGLRY PDEFVKHKIL 

       250        260        270        280        290        300 
DVIGDLYLLG RSLIGSFSGV KSGHTLNSQL LKQLLATKSA WEIVTFKDPS ELPFAYTPVA 


MTA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016828 Genomic DNA. Translation: AAO89706.1.
RefSeqNP_819192.1. NC_002971.3.

3D structure databases

ProteinModelPortalQ83F11.
SMRQ83F11. Positions 1-296.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING227377.CBU_0142.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO89706; AAO89706; CBU_0142.
GeneID1208013.
KEGGcbu:CBU_0142.
PATRIC17928967. VBICoxBur82552_0144.

Phylogenomic databases

eggNOGCOG0774.
HOGENOMHOG000256663.
KOK02535.
OMAKAYKSGH.
OrthoDBEOG6PGK74.
ProtClustDBPRK13186.

Enzyme and pathway databases

BioCycCBUR227377:GJ7S-144-MONOMER.
UniPathwayUPA00359; UER00478.

Family and domain databases

Gene3D3.30.1700.10. 1 hit.
3.30.230.20. 1 hit.
HAMAPMF_00388. LpxC.
InterProIPR020568. Ribosomal_S5_D2-typ_fold.
IPR004463. UDP-acyl_GlcNac_deAcase.
IPR011334. UDP-acyl_GlcNac_deAcase_C.
IPR015870. UDP-acyl_N-AcGlcN_deAcase_N.
[Graphical view]
PfamPF03331. LpxC. 1 hit.
[Graphical view]
SUPFAMSSF54211. SSF54211. 2 hits.
TIGRFAMsTIGR00325. lpxC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLPXC_COXBU
AccessionPrimary (citable) accession number: Q83F11
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2003
Last modified: February 19, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Coxiella burnetii

Coxiella burnetii (strain RSA 493): entries and gene names