Protein translocase subunit SecA - Coxiella burnetii (strain RSA 493 / Nine Mile phase I)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Protein translocase subunit SecA

Gene names

Name:	secA
Ordered Locus Names:	CBU_0147

Organism

Coxiella burnetii (strain RSA 493 / Nine Mile phase I) [Reference proteome] [HAMAP]

Taxonomic identifier

227377 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella ›

Protein attributes

Sequence length	913 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane By similarity. HAMAP-Rule MF_01382
Cofactor	May bind 1 zinc ion per subunit Potential.
Subunit structure	Monomer and homodimer By similarity. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC By similarity.
Subcellular location	Cell inner membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasm By similarity. Note: Distribution is 50-50 By similarity. HAMAP-Rule MF_01382
Sequence similarities	Belongs to the SecA family.
Sequence caution	The sequence AAO89711.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Protein transport Translocation Transport
Cellular component	Cell inner membrane Cell membrane Cytoplasm Membrane
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intracellular protein transmembrane transport Inferred from electronic annotation. Source: HAMAP protein import Inferred from electronic annotation. Source: InterPro protein targeting Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 913

913

Protein translocase subunit SecA HAMAP-Rule MF_01382

PRO_0000320787

Regions

Nucleotide binding

102 – 109

8

ATP Potential

Sites

Metal binding

897

1

Zinc Potential

Metal binding

899

1

Zinc Potential

Metal binding

908

1

Zinc Potential

Metal binding

909

1

Zinc Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q83F06 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: E98BDF59F6CFC2D7
Show »

FASTA

913

103,879

        10         20         30         40         50         60 
MLGNIIKKAF GTRNERLLKG YSKIVSRINA LEPEIQALSD ADLRAKTDEF KKRLVDGEGL 

        70         80         90        100        110        120 
DALLPEAFAV VRETSVRTLG LRHFDVQIIG GLALHGGKIA EMRTGEGKTL GATMPAYLNA 

       130        140        150        160        170        180 
LTGKGVHIVT VNDYLAKRDA EWMKPIYEFL GLTVGVNVPG MEPVEKQAAY AADITYGTNN 

       190        200        210        220        230        240 
EFGFDYLRDN MVFDLDQRVQ RPLHYAIIDE VDSILIDEAR TPLIISGQAE ESSDLYVKIN 

       250        260        270        280        290        300 
KFIPQLKLQK MEEGQKEEEV PPENRGDYTL DEKNRQAYLT EQGHRTIEAL MIKQGLMQAG 

       310        320        330        340        350        360 
ESLYDVSNIS LMHYVYAALR AHTLFYRDVH YIVKNNEVII VDEHTGRLMP GRRWSDGLHQ 

       370        380        390        400        410        420 
AVEAKEGATI QLENQTLATI TFQNYFRLYE KLSGMTATAD TEAFELQKIY GLEVVVIPTN 

       430        440        450        460        470        480 
RPMIRRDESD QVYLTADAKF DAIVNEVKKR HEKGQPLLIG TASIEASELV ARFLKKANIK 

       490        500        510        520        530        540 
HEILNAKNHE REAKIIAEAG RPGAVTIATN MAGRGTDIVL GGNLEAEMSE LDNLAEEEIQ 

       550        560        570        580        590        600 
KRKADWQKRH DAVIAAGGLH VLGTERHESR RIDNQLRGRS GRQGDPGSSQ FYLSMEDNLL 

       610        620        630        640        650        660 
RIFAAERMSN MMRRLGVKED DVIEHPWITR AIEKAQRRVE GMNFDIRKQL LEYDDVANDQ 

       670        680        690        700        710        720 
RKVIYQQRFQ LLQTDDISET IEAIREEAVS EMISSFVPPQ SLEEEWDIPG LEKQIREDFG 

       730        740        750        760        770        780 
LALPIAQWLE KDETLHEETL HKRIIDEITK AYKAKEAKAD PKAMREVEKT LMLQLLDHHW 

       790        800        810        820        830        840 
KEHLAAMDHL RQGIHLRGYA QKNPAQEYKR ESFELFTQML KRIKYELAAT LSKLEIATEE 

       850        860        870        880        890        900 
QVAQQQRLYQ QSAPELQYHH AEMTALQPEK EVAVAEQEEA TQPFVRSQPK VGRNESCPCG 

       910 
SGKKYKQCHG KLS

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References

[1]

"Complete genome sequence of the Q-fever pathogen, Coxiella burnetii."
Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A.

Heidelberg J.F.
Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RSA 493 / Nine Mile phase I.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016828 Genomic DNA. Translation: AAO89711.2. Different initiation.
RefSeq	NP_819197.2. NC_002971.3.
3D structure databases
HSSP	HSSP built from PDB template 1OZB based on UniProtKB P43803.
ProteinModelPortal	Q83F06.
SMR	Q83F06. Positions 10-841.
ModBase	Search...
Protein-protein interaction databases
STRING	227377.CBU_0147.
Proteomic databases
PRIDE	Q83F06.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAO89711; AAO89711; CBU_0147.
GeneID	1208018.
KEGG	cbu:CBU_0147.
PATRIC	17928977. VBICoxBur82552_0149.
Phylogenomic databases
eggNOG	COG0653.
HOGENOM	HOG000218168.
KO	K03070.
OMA	ERFFILQ.
ProtClustDB	PRK12904.
Enzyme and pathway databases
BioCyc	CBUR227377:GJ7S-148-MONOMER.
Family and domain databases
Gene3D	1.10.3060.10. 1 hit. 3.90.1440.10. 1 hit.
HAMAP	MF_01382. SecA.
InterPro	IPR004027. SEC_C_motif. IPR000185. SecA. IPR020937. SecA_CS. IPR011115. SecA_DEAD. IPR014018. SecA_motor_DEAD. IPR011130. SecA_preprotein_X-link_dom. IPR011116. SecA_Wing/Scaffold. [Graphical view]
Pfam	PF02810. SEC-C. 1 hit. PF07517. SecA_DEAD. 1 hit. PF01043. SecA_PP_bind. 1 hit. PF07516. SecA_SW. 1 hit. [Graphical view]
PRINTS	PR00906. SECA.
SMART	SM00957. SecA_DEAD. 1 hit. SM00958. SecA_PP_bind. 1 hit. [Graphical view]
SUPFAM	SSF81767. SecA_PP_bd. 1 hit. SSF81886. SecA_SW. 1 hit.
TIGRFAMs	TIGR00963. secA. 1 hit.
PROSITE	PS01312. SECA. 1 hit. PS51196. SECA_MOTOR_DEAD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SECA_COXBU

Accession

Primary (citable) accession number: Q83F06

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

Coxiella burnetii

Coxiella burnetii (strain RSA 493): entries and gene names

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents