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Q83F06

- SECA_COXBU

UniProt

Q83F06 - SECA_COXBU

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Protein

Protein translocase subunit SecA

Gene

secA

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: May bind 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi897 – 8971ZincUniRule annotation
Metal bindingi899 – 8991ZincUniRule annotation
Metal bindingi908 – 9081ZincUniRule annotation
Metal bindingi909 – 9091ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi102 – 1098ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. intracellular protein transmembrane transport Source: UniProtKB-HAMAP
  2. protein import Source: InterPro
  3. protein targeting Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-148-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecAUniRule annotation
Gene namesi
Name:secAUniRule annotation
Ordered Locus Names:CBU_0147
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation. Cytoplasm UniRule annotation
Note: Distribution is 50-50.UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 913913Protein translocase subunit SecAPRO_0000320787Add
BLAST

Proteomic databases

PRIDEiQ83F06.

Interactioni

Subunit structurei

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.UniRule annotation

Protein-protein interaction databases

STRINGi227377.CBU_0147.

Structurei

3D structure databases

ProteinModelPortaliQ83F06.
SMRiQ83F06. Positions 10-841.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecA family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0653.
HOGENOMiHOG000218168.
KOiK03070.
OMAiEAYEFQQ.
OrthoDBiEOG654P48.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA.
InterProiIPR027417. P-loop_NTPase.
IPR004027. SEC_C_motif.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF02810. SEC-C. 1 hit.
PF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 2 hits.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q83F06-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLGNIIKKAF GTRNERLLKG YSKIVSRINA LEPEIQALSD ADLRAKTDEF
60 70 80 90 100
KKRLVDGEGL DALLPEAFAV VRETSVRTLG LRHFDVQIIG GLALHGGKIA
110 120 130 140 150
EMRTGEGKTL GATMPAYLNA LTGKGVHIVT VNDYLAKRDA EWMKPIYEFL
160 170 180 190 200
GLTVGVNVPG MEPVEKQAAY AADITYGTNN EFGFDYLRDN MVFDLDQRVQ
210 220 230 240 250
RPLHYAIIDE VDSILIDEAR TPLIISGQAE ESSDLYVKIN KFIPQLKLQK
260 270 280 290 300
MEEGQKEEEV PPENRGDYTL DEKNRQAYLT EQGHRTIEAL MIKQGLMQAG
310 320 330 340 350
ESLYDVSNIS LMHYVYAALR AHTLFYRDVH YIVKNNEVII VDEHTGRLMP
360 370 380 390 400
GRRWSDGLHQ AVEAKEGATI QLENQTLATI TFQNYFRLYE KLSGMTATAD
410 420 430 440 450
TEAFELQKIY GLEVVVIPTN RPMIRRDESD QVYLTADAKF DAIVNEVKKR
460 470 480 490 500
HEKGQPLLIG TASIEASELV ARFLKKANIK HEILNAKNHE REAKIIAEAG
510 520 530 540 550
RPGAVTIATN MAGRGTDIVL GGNLEAEMSE LDNLAEEEIQ KRKADWQKRH
560 570 580 590 600
DAVIAAGGLH VLGTERHESR RIDNQLRGRS GRQGDPGSSQ FYLSMEDNLL
610 620 630 640 650
RIFAAERMSN MMRRLGVKED DVIEHPWITR AIEKAQRRVE GMNFDIRKQL
660 670 680 690 700
LEYDDVANDQ RKVIYQQRFQ LLQTDDISET IEAIREEAVS EMISSFVPPQ
710 720 730 740 750
SLEEEWDIPG LEKQIREDFG LALPIAQWLE KDETLHEETL HKRIIDEITK
760 770 780 790 800
AYKAKEAKAD PKAMREVEKT LMLQLLDHHW KEHLAAMDHL RQGIHLRGYA
810 820 830 840 850
QKNPAQEYKR ESFELFTQML KRIKYELAAT LSKLEIATEE QVAQQQRLYQ
860 870 880 890 900
QSAPELQYHH AEMTALQPEK EVAVAEQEEA TQPFVRSQPK VGRNESCPCG
910
SGKKYKQCHG KLS
Length:913
Mass (Da):103,879
Last modified:June 1, 2003 - v1
Checksum:iE98BDF59F6CFC2D7
GO

Sequence cautioni

The sequence AAO89711.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO89711.2. Different initiation.
RefSeqiNP_819197.2. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO89711; AAO89711; CBU_0147.
GeneIDi1208018.
KEGGicbu:CBU_0147.
PATRICi17928977. VBICoxBur82552_0149.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO89711.2 . Different initiation.
RefSeqi NP_819197.2. NC_002971.3.

3D structure databases

ProteinModelPortali Q83F06.
SMRi Q83F06. Positions 10-841.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227377.CBU_0147.

Proteomic databases

PRIDEi Q83F06.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO89711 ; AAO89711 ; CBU_0147 .
GeneIDi 1208018.
KEGGi cbu:CBU_0147.
PATRICi 17928977. VBICoxBur82552_0149.

Phylogenomic databases

eggNOGi COG0653.
HOGENOMi HOG000218168.
KOi K03070.
OMAi EAYEFQQ.
OrthoDBi EOG654P48.

Enzyme and pathway databases

BioCyci CBUR227377:GJ7S-148-MONOMER.

Family and domain databases

Gene3Di 1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPi MF_01382. SecA.
InterProi IPR027417. P-loop_NTPase.
IPR004027. SEC_C_motif.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view ]
Pfami PF02810. SEC-C. 1 hit.
PF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view ]
PRINTSi PR00906. SECA.
SMARTi SM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 2 hits.
TIGRFAMsi TIGR00963. secA. 1 hit.
PROSITEi PS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiSECA_COXBU
AccessioniPrimary (citable) accession number: Q83F06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 1, 2003
Last modified: November 26, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3