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Q83F06

- SECA_COXBU

UniProt

Q83F06 - SECA_COXBU

Protein

Protein translocase subunit SecA

Gene

secA

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

    Cofactori

    May bind 1 zinc ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi897 – 8971ZincUniRule annotation
    Metal bindingi899 – 8991ZincUniRule annotation
    Metal bindingi908 – 9081ZincUniRule annotation
    Metal bindingi909 – 9091ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi102 – 1098ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. intracellular protein transmembrane transport Source: UniProtKB-HAMAP
    2. protein import Source: InterPro
    3. protein targeting Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Protein transport, Translocation, Transport

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciCBUR227377:GJ7S-148-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein translocase subunit SecAUniRule annotation
    Gene namesi
    Name:secAUniRule annotation
    Ordered Locus Names:CBU_0147
    OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
    Taxonomic identifieri227377 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
    ProteomesiUP000002671: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation. Cytoplasm UniRule annotation
    Note: Distribution is 50-50.UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 913913Protein translocase subunit SecAPRO_0000320787Add
    BLAST

    Proteomic databases

    PRIDEiQ83F06.

    Interactioni

    Subunit structurei

    Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.UniRule annotation

    Protein-protein interaction databases

    STRINGi227377.CBU_0147.

    Structurei

    3D structure databases

    ProteinModelPortaliQ83F06.
    SMRiQ83F06. Positions 10-841.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SecA family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0653.
    HOGENOMiHOG000218168.
    KOiK03070.
    OMAiEAYEFQQ.
    OrthoDBiEOG654P48.

    Family and domain databases

    Gene3Di1.10.3060.10. 1 hit.
    3.40.50.300. 3 hits.
    3.90.1440.10. 1 hit.
    HAMAPiMF_01382. SecA.
    InterProiIPR027417. P-loop_NTPase.
    IPR004027. SEC_C_motif.
    IPR000185. SecA.
    IPR020937. SecA_CS.
    IPR011115. SecA_DEAD.
    IPR014018. SecA_motor_DEAD.
    IPR011130. SecA_preprotein_X-link_dom.
    IPR011116. SecA_Wing/Scaffold.
    [Graphical view]
    PfamiPF02810. SEC-C. 1 hit.
    PF07517. SecA_DEAD. 1 hit.
    PF01043. SecA_PP_bind. 1 hit.
    PF07516. SecA_SW. 1 hit.
    [Graphical view]
    PRINTSiPR00906. SECA.
    SMARTiSM00957. SecA_DEAD. 1 hit.
    SM00958. SecA_PP_bind. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 3 hits.
    SSF81767. SSF81767. 1 hit.
    SSF81886. SSF81886. 2 hits.
    TIGRFAMsiTIGR00963. secA. 1 hit.
    PROSITEiPS01312. SECA. 1 hit.
    PS51196. SECA_MOTOR_DEAD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q83F06-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLGNIIKKAF GTRNERLLKG YSKIVSRINA LEPEIQALSD ADLRAKTDEF    50
    KKRLVDGEGL DALLPEAFAV VRETSVRTLG LRHFDVQIIG GLALHGGKIA 100
    EMRTGEGKTL GATMPAYLNA LTGKGVHIVT VNDYLAKRDA EWMKPIYEFL 150
    GLTVGVNVPG MEPVEKQAAY AADITYGTNN EFGFDYLRDN MVFDLDQRVQ 200
    RPLHYAIIDE VDSILIDEAR TPLIISGQAE ESSDLYVKIN KFIPQLKLQK 250
    MEEGQKEEEV PPENRGDYTL DEKNRQAYLT EQGHRTIEAL MIKQGLMQAG 300
    ESLYDVSNIS LMHYVYAALR AHTLFYRDVH YIVKNNEVII VDEHTGRLMP 350
    GRRWSDGLHQ AVEAKEGATI QLENQTLATI TFQNYFRLYE KLSGMTATAD 400
    TEAFELQKIY GLEVVVIPTN RPMIRRDESD QVYLTADAKF DAIVNEVKKR 450
    HEKGQPLLIG TASIEASELV ARFLKKANIK HEILNAKNHE REAKIIAEAG 500
    RPGAVTIATN MAGRGTDIVL GGNLEAEMSE LDNLAEEEIQ KRKADWQKRH 550
    DAVIAAGGLH VLGTERHESR RIDNQLRGRS GRQGDPGSSQ FYLSMEDNLL 600
    RIFAAERMSN MMRRLGVKED DVIEHPWITR AIEKAQRRVE GMNFDIRKQL 650
    LEYDDVANDQ RKVIYQQRFQ LLQTDDISET IEAIREEAVS EMISSFVPPQ 700
    SLEEEWDIPG LEKQIREDFG LALPIAQWLE KDETLHEETL HKRIIDEITK 750
    AYKAKEAKAD PKAMREVEKT LMLQLLDHHW KEHLAAMDHL RQGIHLRGYA 800
    QKNPAQEYKR ESFELFTQML KRIKYELAAT LSKLEIATEE QVAQQQRLYQ 850
    QSAPELQYHH AEMTALQPEK EVAVAEQEEA TQPFVRSQPK VGRNESCPCG 900
    SGKKYKQCHG KLS 913
    Length:913
    Mass (Da):103,879
    Last modified:June 1, 2003 - v1
    Checksum:iE98BDF59F6CFC2D7
    GO

    Sequence cautioni

    The sequence AAO89711.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO89711.2. Different initiation.
    RefSeqiNP_819197.2. NC_002971.3.

    Genome annotation databases

    EnsemblBacteriaiAAO89711; AAO89711; CBU_0147.
    GeneIDi1208018.
    KEGGicbu:CBU_0147.
    PATRICi17928977. VBICoxBur82552_0149.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO89711.2 . Different initiation.
    RefSeqi NP_819197.2. NC_002971.3.

    3D structure databases

    ProteinModelPortali Q83F06.
    SMRi Q83F06. Positions 10-841.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 227377.CBU_0147.

    Proteomic databases

    PRIDEi Q83F06.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO89711 ; AAO89711 ; CBU_0147 .
    GeneIDi 1208018.
    KEGGi cbu:CBU_0147.
    PATRICi 17928977. VBICoxBur82552_0149.

    Phylogenomic databases

    eggNOGi COG0653.
    HOGENOMi HOG000218168.
    KOi K03070.
    OMAi EAYEFQQ.
    OrthoDBi EOG654P48.

    Enzyme and pathway databases

    BioCyci CBUR227377:GJ7S-148-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3060.10. 1 hit.
    3.40.50.300. 3 hits.
    3.90.1440.10. 1 hit.
    HAMAPi MF_01382. SecA.
    InterProi IPR027417. P-loop_NTPase.
    IPR004027. SEC_C_motif.
    IPR000185. SecA.
    IPR020937. SecA_CS.
    IPR011115. SecA_DEAD.
    IPR014018. SecA_motor_DEAD.
    IPR011130. SecA_preprotein_X-link_dom.
    IPR011116. SecA_Wing/Scaffold.
    [Graphical view ]
    Pfami PF02810. SEC-C. 1 hit.
    PF07517. SecA_DEAD. 1 hit.
    PF01043. SecA_PP_bind. 1 hit.
    PF07516. SecA_SW. 1 hit.
    [Graphical view ]
    PRINTSi PR00906. SECA.
    SMARTi SM00957. SecA_DEAD. 1 hit.
    SM00958. SecA_PP_bind. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 3 hits.
    SSF81767. SSF81767. 1 hit.
    SSF81886. SSF81886. 2 hits.
    TIGRFAMsi TIGR00963. secA. 1 hit.
    PROSITEi PS01312. SECA. 1 hit.
    PS51196. SECA_MOTOR_DEAD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RSA 493 / Nine Mile phase I.

    Entry informationi

    Entry nameiSECA_COXBU
    AccessioniPrimary (citable) accession number: Q83F06
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Coxiella burnetii
      Coxiella burnetii (strain RSA 493): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3