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Q83F06

- SECA_COXBU

UniProt

Q83F06 - SECA_COXBU

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Protein

Protein translocase subunit SecA

Gene
secA, CBU_0147
Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane By similarity.UniRule annotation

Cofactori

May bind 1 zinc ion per subunit Reviewed prediction.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi897 – 8971Zinc Reviewed prediction
Metal bindingi899 – 8991Zinc Reviewed prediction
Metal bindingi908 – 9081Zinc Reviewed prediction
Metal bindingi909 – 9091Zinc Reviewed prediction

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi102 – 1098ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. intracellular protein transmembrane transport Source: UniProtKB-HAMAP
  2. protein import Source: InterPro
  3. protein targeting Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-148-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecA
Gene namesi
Name:secA
Ordered Locus Names:CBU_0147
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671: Chromosome

Subcellular locationi

Cell inner membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasm By similarity
Note: Distribution is 50-50 By similarity.UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 913913Protein translocase subunit SecAUniRule annotationPRO_0000320787Add
BLAST

Proteomic databases

PRIDEiQ83F06.

Interactioni

Subunit structurei

Monomer and homodimer By similarity. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi227377.CBU_0147.

Structurei

3D structure databases

ProteinModelPortaliQ83F06.
SMRiQ83F06. Positions 10-841.

Family & Domainsi

Sequence similaritiesi

Belongs to the SecA family.

Phylogenomic databases

eggNOGiCOG0653.
HOGENOMiHOG000218168.
KOiK03070.
OMAiEAYEFQQ.
OrthoDBiEOG654P48.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA.
InterProiIPR027417. P-loop_NTPase.
IPR004027. SEC_C_motif.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF02810. SEC-C. 1 hit.
PF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 2 hits.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q83F06-1 [UniParc]FASTAAdd to Basket

« Hide

MLGNIIKKAF GTRNERLLKG YSKIVSRINA LEPEIQALSD ADLRAKTDEF    50
KKRLVDGEGL DALLPEAFAV VRETSVRTLG LRHFDVQIIG GLALHGGKIA 100
EMRTGEGKTL GATMPAYLNA LTGKGVHIVT VNDYLAKRDA EWMKPIYEFL 150
GLTVGVNVPG MEPVEKQAAY AADITYGTNN EFGFDYLRDN MVFDLDQRVQ 200
RPLHYAIIDE VDSILIDEAR TPLIISGQAE ESSDLYVKIN KFIPQLKLQK 250
MEEGQKEEEV PPENRGDYTL DEKNRQAYLT EQGHRTIEAL MIKQGLMQAG 300
ESLYDVSNIS LMHYVYAALR AHTLFYRDVH YIVKNNEVII VDEHTGRLMP 350
GRRWSDGLHQ AVEAKEGATI QLENQTLATI TFQNYFRLYE KLSGMTATAD 400
TEAFELQKIY GLEVVVIPTN RPMIRRDESD QVYLTADAKF DAIVNEVKKR 450
HEKGQPLLIG TASIEASELV ARFLKKANIK HEILNAKNHE REAKIIAEAG 500
RPGAVTIATN MAGRGTDIVL GGNLEAEMSE LDNLAEEEIQ KRKADWQKRH 550
DAVIAAGGLH VLGTERHESR RIDNQLRGRS GRQGDPGSSQ FYLSMEDNLL 600
RIFAAERMSN MMRRLGVKED DVIEHPWITR AIEKAQRRVE GMNFDIRKQL 650
LEYDDVANDQ RKVIYQQRFQ LLQTDDISET IEAIREEAVS EMISSFVPPQ 700
SLEEEWDIPG LEKQIREDFG LALPIAQWLE KDETLHEETL HKRIIDEITK 750
AYKAKEAKAD PKAMREVEKT LMLQLLDHHW KEHLAAMDHL RQGIHLRGYA 800
QKNPAQEYKR ESFELFTQML KRIKYELAAT LSKLEIATEE QVAQQQRLYQ 850
QSAPELQYHH AEMTALQPEK EVAVAEQEEA TQPFVRSQPK VGRNESCPCG 900
SGKKYKQCHG KLS 913
Length:913
Mass (Da):103,879
Last modified:June 1, 2003 - v1
Checksum:iE98BDF59F6CFC2D7
GO

Sequence cautioni

The sequence AAO89711.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016828 Genomic DNA. Translation: AAO89711.2. Different initiation.
RefSeqiNP_819197.2. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO89711; AAO89711; CBU_0147.
GeneIDi1208018.
KEGGicbu:CBU_0147.
PATRICi17928977. VBICoxBur82552_0149.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016828 Genomic DNA. Translation: AAO89711.2 . Different initiation.
RefSeqi NP_819197.2. NC_002971.3.

3D structure databases

ProteinModelPortali Q83F06.
SMRi Q83F06. Positions 10-841.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227377.CBU_0147.

Proteomic databases

PRIDEi Q83F06.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO89711 ; AAO89711 ; CBU_0147 .
GeneIDi 1208018.
KEGGi cbu:CBU_0147.
PATRICi 17928977. VBICoxBur82552_0149.

Phylogenomic databases

eggNOGi COG0653.
HOGENOMi HOG000218168.
KOi K03070.
OMAi EAYEFQQ.
OrthoDBi EOG654P48.

Enzyme and pathway databases

BioCyci CBUR227377:GJ7S-148-MONOMER.

Family and domain databases

Gene3Di 1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPi MF_01382. SecA.
InterProi IPR027417. P-loop_NTPase.
IPR004027. SEC_C_motif.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view ]
Pfami PF02810. SEC-C. 1 hit.
PF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view ]
PRINTSi PR00906. SECA.
SMARTi SM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 2 hits.
TIGRFAMsi TIGR00963. secA. 1 hit.
PROSITEi PS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiSECA_COXBU
AccessioniPrimary (citable) accession number: Q83F06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi