ID   COAA_COXBU              Reviewed;         318 AA.
AC   Q83EV9;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   16-JUN-2009, entry version 40.
DE   RecName: Full=Pantothenate kinase;
DE            EC=2.7.1.33;
DE   AltName: Full=Pantothenic acid kinase;
GN   Name=coaA; OrderedLocusNames=CBU_0199;
OS   Coxiella burnetii.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales;
OC   Coxiellaceae; Coxiella.
OX   NCBI_TaxID=777;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nine Mile phase I / RSA 493;
RX   MEDLINE=22608657; PubMed=12704232; DOI=10.1073/pnas.0931379100;
RA   Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E.,
RA   Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J.,
RA   DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J.,
RA   Khouri H.M., Lee K.H., Carty H.A., Scanlan D., Heinzen R.A.,
RA   Thompson H.A., Samuel J.E., Fraser C.M., Heidelberg J.F.;
RT   "Complete genome sequence of the Q-fever pathogen, Coxiella
RT   burnetii.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003).
CC   -!- CATALYTIC ACTIVITY: ATP + (R)-pantothenate = ADP + (R)-4'-
CC       phosphopantothenate.
CC   -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; coenzyme
CC       A from pantothenate: step 1/5.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Probable).
CC   -!- SIMILARITY: Belongs to the prokaryotic pantothenate kinase family.
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DR   EMBL; AE016828; AAO89759.1; -; Genomic_DNA.
DR   RefSeq; NP_819245.1; -.
DR   HSSP; P15044; 1ESM.
DR   GeneID; 1208075; -.
DR   GenomeReviews; AE016828_GR; CBU_0199.
DR   KEGG; cbu:CBU_0199; -.
DR   NMPDR; fig|227377.1.peg.189; -.
DR   TIGR; CBU_0199; -.
DR   HOGENOM; Q83EV9; -.
DR   OMA; Q83EV9; PKVDLIT.
DR   BioCyc; CBUR227377:CBU_0199-MON; -.
DR   BRENDA; 2.7.1.33; 256353.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0004594; F:pantothenate kinase activity; IEA:HAMAP.
DR   GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00215; -; 1.
DR   InterPro; IPR004566; PanK_bact.
DR   PANTHER; PTHR10285:SF7; PanK_bact; 1.
DR   PIRSF; PIRSF000545; Pantothenate_kin; 1.
DR   TIGRFAMs; TIGR00554; panK_bact; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coenzyme A biosynthesis; Complete proteome; Cytoplasm;
KW   Kinase; Nucleotide-binding; Transferase.
FT   CHAIN         1    318       Pantothenate kinase.
FT                                /FTId=PRO_0000194425.
FT   NP_BIND      96    103       ATP (Potential).
SQ   SEQUENCE   318 AA;  36922 MW;  C6836DD88B83785B CRC64;
     MTVKPELNEI TPYLQFNRQQ WGNFRKDTPL TLTESDLDKL QGQIEIVSLK EVTEIYLPLS
     RLLSFYVTAR QTLQQATYQF LGKPEPKVPY IIGIAGSVAV GKSTTSRVLK ALLSRWPDHP
     NVEVITTDGF LYSNAKLEKQ GLMKRKGFPE SYDMPSLLRV LNAIKSGQRN VRIPVYSHHY
     YDIVRGQYEI VDQPDIVILE GLNILQTGVR KTLQQLQVFV SDFFDFSLFV DAQAQVIQKW
     YIDRVLSFWR TTFKDPHSYF HYLTQMSETE VAAFAKHVWN EINKVNLMEN ILPYKNRAQL
     ILEKAADHSI QKVYLRKI
//