Q83EV9 (COAA_COXBU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pantothenate kinase
EC=2.7.1.33

Alternative name(s):
Pantothenic acid kinase

Gene names

Name:	coaA
Ordered Locus Names:	CBU_0199

Organism

Coxiella burnetii

Taxonomic identifier

777 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella

Protein attributes

Sequence length	318 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate. HAMAP MF_00215
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. HAMAP MF_00215
Subcellular location	Cytoplasm Probable HAMAP MF_00215.
Sequence similarities	Belongs to the prokaryotic pantothenate kinase family.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantothenate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 318	318	Pantothenate kinase HAMAP MF_00215		PRO_0000194425
Regions
	Nucleotide binding	96 – 103	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q83EV9 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: C6836DD88B83785B	FASTA	318	36,922
	10 20 30 40 50 60 MTVKPELNEI TPYLQFNRQQ WGNFRKDTPL TLTESDLDKL QGQIEIVSLK EVTEIYLPLS 70 80 90 100 110 120 RLLSFYVTAR QTLQQATYQF LGKPEPKVPY IIGIAGSVAV GKSTTSRVLK ALLSRWPDHP 130 140 150 160 170 180 NVEVITTDGF LYSNAKLEKQ GLMKRKGFPE SYDMPSLLRV LNAIKSGQRN VRIPVYSHHY 190 200 210 220 230 240 YDIVRGQYEI VDQPDIVILE GLNILQTGVR KTLQQLQVFV SDFFDFSLFV DAQAQVIQKW 250 260 270 280 290 300 YIDRVLSFWR TTFKDPHSYF HYLTQMSETE VAAFAKHVWN EINKVNLMEN ILPYKNRAQL 310 ILEKAADHSI QKVYLRKI

References

[1]

"Complete genome sequence of the Q-fever pathogen, Coxiella burnetii." Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A. , Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E., Fraser C.M., Heidelberg J.F. Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed: 12704232] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nine Mile phase I / RSA 493.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE016828 Genomic DNA. Translation: AAO89759.1.

RefSeq

NP_819245.1. NC_002971.3.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3TQC	X-ray	2.30	A/B	1-318	[»]

ProteinModelPortal

Q83EV9.

SMR

Q83EV9. Positions 9-317.

ModBase

Search...

Proteomic databases

PRIDE

Q83EV9.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

1208075.

GenomeReviews

Gene locus CBU_0199 in contig AE016828_GR.

KEGG

cbu:CBU_0199.

NMPDR

fig|227377.1.peg.189.

PATRIC

17929087. VBICoxBur82552_0197.

TIGR

CBU_0199.

Phylogenomic databases

HOGENOM

HBG732538.

OMA

EVYLPLS.

PhylomeDB

Q83EV9.

ProtClustDB

PRK05439.

Enzyme and pathway databases

BioCyc

CBUR227377:CBU_0199-MONOMER.

Family and domain databases

HAMAP

MF_00215. Pantothen_kinase_1.
[Tree]

InterPro

IPR004566. PanK_bact.
IPR006083. PRK/URK.
[Graphical view]

KO

K00867.

PANTHER

PTHR10285:SF7. PanK_bact. 1 hit.

Pfam

PF00485. PRK. 1 hit.
[Graphical view]

PIRSF

PIRSF000545. Pantothenate_kin. 1 hit.

TIGRFAMs

TIGR00554. PanK_bact. 1 hit.

ProtoNet

Search...

Entry information

Entry name

COAA_COXBU

Accession

Primary (citable) accession number: Q83EV9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2004
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program