Reviewed, UniProtKB/Swiss-Prot Q83EV9 (COAA_COXBU)

Names and origin

Protein names

Recommended name:
    Pantothenate kinase
    EC=2.7.1.33
Alternative name(s):
    Pantothenic acid kinase

Gene names

Name:	coaA
Ordered Locus Names:	CBU_0199

Organism

Coxiella burnetii [Complete proteome] [HAMAP]

Taxonomic identifier

777 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella

Protein attributes

Sequence length	318 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate. HAMAP MF_00215
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. HAMAP MF_00215
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the prokaryotic pantothenate kinase family.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP pantothenate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 318	318	Pantothenate kinase HAMAP MF_00215		PRO_0000194425
Regions
	Nucleotide binding	96 – 103	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q83EV9-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: C6836DD88B83785B	FASTA	318	36,922
	10 20 30 40 50 60 MTVKPELNEI TPYLQFNRQQ WGNFRKDTPL TLTESDLDKL QGQIEIVSLK EVTEIYLPLS 70 80 90 100 110 120 RLLSFYVTAR QTLQQATYQF LGKPEPKVPY IIGIAGSVAV GKSTTSRVLK ALLSRWPDHP 130 140 150 160 170 180 NVEVITTDGF LYSNAKLEKQ GLMKRKGFPE SYDMPSLLRV LNAIKSGQRN VRIPVYSHHY 190 200 210 220 230 240 YDIVRGQYEI VDQPDIVILE GLNILQTGVR KTLQQLQVFV SDFFDFSLFV DAQAQVIQKW 250 260 270 280 290 300 YIDRVLSFWR TTFKDPHSYF HYLTQMSETE VAAFAKHVWN EINKVNLMEN ILPYKNRAQL 310 ILEKAADHSI QKVYLRKI

References

[1]

"Complete genome sequence of the Q-fever pathogen, Coxiella burnetii." Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A. , Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E., Fraser C.M., Heidelberg J.F. Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed: 12704232] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nine Mile phase I / RSA 493.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016828 Genomic DNA. Translation: AAO89759.1.
RefSeq	NP_819245.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1208075.
GenomeReviews	Gene locus CBU_0199 in contig AE016828_GR.
KEGG	cbu:CBU_0199.
NMPDR	fig|227377.1.peg.189.
TIGR	CBU_0199.
Phylogenomic databases
HOGENOM	Q83EV9.
OMA	PKVDLIT
Enzyme and pathway databases
BioCyc	CBUR227377:CBU_0199-MON.
BRENDA	2.7.1.33. 256353.
Family and domain databases
HAMAP	MF_00215. [Tree]
InterPro	IPR004566. PanK_bact. [Graphical view]
PANTHER	PTHR10285:SF7. PanK_bact. 1 hit.
PIRSF	PIRSF000545. Pantothenate_kin. 1 hit.
TIGRFAMs	TIGR00554. panK_bact. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COAA_COXBU

Accession

Primary (citable) accession number: Q83EV9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2004
Last sequence update:	June 1, 2003
Last modified:	November 24, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)