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Q83ES7 (EFG_COXBU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Elongation factor G

Short name=EF-G
Gene names
Name:fusA
Ordered Locus Names:CBU_0235
OrganismCoxiella burnetii (strain RSA 493 / Nine Mile phase I) [Reference proteome] [HAMAP]
Taxonomic identifier227377 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella

Protein attributes

Sequence length699 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome By similarity. HAMAP-Rule MF_00054

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00054.

Sequence similarities

Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandGTP-binding
Nucleotide-binding
   Molecular functionElongation factor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

GTPase activity

Inferred from electronic annotation. Source: InterPro

translation elongation factor activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 699699Elongation factor G HAMAP-Rule MF_00054
PRO_0000091114

Regions

Nucleotide binding19 – 268GTP By similarity
Nucleotide binding90 – 945GTP By similarity
Nucleotide binding144 – 1474GTP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q83ES7 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 88D6509939F8193D

FASTA69977,733
        10         20         30         40         50         60 
MATAREIPLN RTRNIGIMAH IDAGKTTTTE RVLYYTGVSH KMGEVHEGSA VMDWMEQEQE 

        70         80         90        100        110        120 
RGITITSAAT TCYWLGMDQQ YPKHRINIID TPGHVDFTIE VERSLRVLDG AVAVFCSVGG 

       130        140        150        160        170        180 
VEPQSETVWR QANRYHVPRL GFVNKMDRAG ANFLRVVNQV KDRLNANPIP IQLPIGAEED 

       190        200        210        220        230        240 
FKGVIDLIRE KAIYWNEADR GRTYELADIP EDMKAEVQKW REKMIEAAAE SSEELMDKYL 

       250        260        270        280        290        300 
EAGDLSPEQI RQGLRQRTLA NEIVPILCGS AFKNKGVQAL LDAVIDYLPS PTDVPAIRGE 

       310        320        330        340        350        360 
EDDGSEGSRS ASDDEPFAAL AFKIASDPFV GTLTFFRVYS GILKSGDSVY NPIKGKKERI 

       370        380        390        400        410        420 
GRLLQMHSNS REEIKEVRAG DIAAAVGLKT VTTGDTICNQ QNIITLEKMD FPEPVISVAI 

       430        440        450        460        470        480 
EPKTKADQEK MGVALGKLAQ EDPSFRVHTD EESAQTIIEG MGELHLEIIV DRMRREFNVE 

       490        500        510        520        530        540 
ANVGKPRVAY RETIRRSVEQ QGKYIRQTGG RGQYGDVWLR IEPREPGAGF EFENAIVGGV 

       550        560        570        580        590        600 
VPREYIPAVE KGVREQMENG IRAGYPVVDV KVTIFEGSYH DVDSSEMAFK IAGSMAFKEG 

       610        620        630        640        650        660 
ASKADPVLLE PIMKVEVVTP EEYMGDVVGD LNRRRGMIQG MDESPAGKIV DVEVPLAEMF 

       670        680        690 
GYATDLRSLS QGRATYTMEF LKYAEAPSNI AEAIIKQQS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016828 Genomic DNA. Translation: AAO89793.1.
RefSeqNP_819279.1. NC_002971.3.

3D structure databases

ProteinModelPortalQ83ES7.
SMRQ83ES7. Positions 1-696.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING227377.CBU_0235.

Proteomic databases

PRIDEQ83ES7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO89793; AAO89793; CBU_0235.
GeneID1208116.
KEGGcbu:CBU_0235.
PATRIC17929163. VBICoxBur82552_0230.

Phylogenomic databases

eggNOGCOG0480.
HOGENOMHOG000231585.
KOK02355.
OMAKGIQEAM.
OrthoDBEOG6X6RBF.
ProtClustDBPRK00007.

Enzyme and pathway databases

BioCycCBUR227377:GJ7S-241-MONOMER.

Family and domain databases

Gene3D3.30.230.10. 1 hit.
3.30.70.240. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_00054_B. EF_G_EF_2_B.
InterProIPR000795. EF_GTP-bd_dom.
IPR009022. EFG_III-V.
IPR000640. EFG_V.
IPR027417. P-loop_NTPase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR004540. Transl_elong_EFG/EF2.
IPR005517. Transl_elong_EFG/EF2_IV.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PfamPF00679. EFG_C. 1 hit.
PF14492. EFG_II. 1 hit.
PF03764. EFG_IV. 1 hit.
PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSPR00315. ELONGATNFCT.
SMARTSM00838. EFG_C. 1 hit.
SM00889. EFG_IV. 1 hit.
[Graphical view]
SUPFAMSSF50447. SSF50447. 2 hits.
SSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF54980. SSF54980. 2 hits.
TIGRFAMsTIGR00484. EF-G. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEPS00301. EFACTOR_GTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameEFG_COXBU
AccessionPrimary (citable) accession number: Q83ES7
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Coxiella burnetii

Coxiella burnetii (strain RSA 493): entries and gene names