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Protein

Elongation factor G

Gene

fusA

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 268GTPUniRule annotation
Nucleotide bindingi90 – 945GTPUniRule annotation
Nucleotide bindingi144 – 1474GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: InterPro
  2. GTP binding Source: UniProtKB-HAMAP
  3. translation elongation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-241-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor GUniRule annotation
Short name:
EF-GUniRule annotation
Gene namesi
Name:fusAUniRule annotation
Ordered Locus Names:CBU_0235
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 699699Elongation factor GPRO_0000091114Add
BLAST

Proteomic databases

PRIDEiQ83ES7.

Interactioni

Protein-protein interaction databases

STRINGi227377.CBU_0235.

Structurei

3D structure databases

ProteinModelPortaliQ83ES7.
SMRiQ83ES7. Positions 1-696.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 292283tr-type GAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0480.
HOGENOMiHOG000231585.
KOiK02355.
OMAiKLTFVRM.
OrthoDBiEOG6X6RBF.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.240. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00054_B. EF_G_EF_2_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR009022. EFG_III-V.
IPR000640. EFG_V.
IPR027417. P-loop_NTPase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR004540. Transl_elong_EFG/EF2.
IPR005517. Transl_elong_EFG/EF2_IV.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PfamiPF00679. EFG_C. 1 hit.
PF14492. EFG_II. 1 hit.
PF03764. EFG_IV. 1 hit.
PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SMARTiSM00838. EFG_C. 1 hit.
SM00889. EFG_IV. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF54980. SSF54980. 2 hits.
TIGRFAMsiTIGR00484. EF-G. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q83ES7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATAREIPLN RTRNIGIMAH IDAGKTTTTE RVLYYTGVSH KMGEVHEGSA
60 70 80 90 100
VMDWMEQEQE RGITITSAAT TCYWLGMDQQ YPKHRINIID TPGHVDFTIE
110 120 130 140 150
VERSLRVLDG AVAVFCSVGG VEPQSETVWR QANRYHVPRL GFVNKMDRAG
160 170 180 190 200
ANFLRVVNQV KDRLNANPIP IQLPIGAEED FKGVIDLIRE KAIYWNEADR
210 220 230 240 250
GRTYELADIP EDMKAEVQKW REKMIEAAAE SSEELMDKYL EAGDLSPEQI
260 270 280 290 300
RQGLRQRTLA NEIVPILCGS AFKNKGVQAL LDAVIDYLPS PTDVPAIRGE
310 320 330 340 350
EDDGSEGSRS ASDDEPFAAL AFKIASDPFV GTLTFFRVYS GILKSGDSVY
360 370 380 390 400
NPIKGKKERI GRLLQMHSNS REEIKEVRAG DIAAAVGLKT VTTGDTICNQ
410 420 430 440 450
QNIITLEKMD FPEPVISVAI EPKTKADQEK MGVALGKLAQ EDPSFRVHTD
460 470 480 490 500
EESAQTIIEG MGELHLEIIV DRMRREFNVE ANVGKPRVAY RETIRRSVEQ
510 520 530 540 550
QGKYIRQTGG RGQYGDVWLR IEPREPGAGF EFENAIVGGV VPREYIPAVE
560 570 580 590 600
KGVREQMENG IRAGYPVVDV KVTIFEGSYH DVDSSEMAFK IAGSMAFKEG
610 620 630 640 650
ASKADPVLLE PIMKVEVVTP EEYMGDVVGD LNRRRGMIQG MDESPAGKIV
660 670 680 690
DVEVPLAEMF GYATDLRSLS QGRATYTMEF LKYAEAPSNI AEAIIKQQS
Length:699
Mass (Da):77,733
Last modified:June 1, 2003 - v1
Checksum:i88D6509939F8193D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO89793.1.
RefSeqiNP_819279.1. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO89793; AAO89793; CBU_0235.
GeneIDi1208116.
KEGGicbu:CBU_0235.
PATRICi17929163. VBICoxBur82552_0230.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO89793.1.
RefSeqiNP_819279.1. NC_002971.3.

3D structure databases

ProteinModelPortaliQ83ES7.
SMRiQ83ES7. Positions 1-696.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi227377.CBU_0235.

Proteomic databases

PRIDEiQ83ES7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO89793; AAO89793; CBU_0235.
GeneIDi1208116.
KEGGicbu:CBU_0235.
PATRICi17929163. VBICoxBur82552_0230.

Phylogenomic databases

eggNOGiCOG0480.
HOGENOMiHOG000231585.
KOiK02355.
OMAiKLTFVRM.
OrthoDBiEOG6X6RBF.

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-241-MONOMER.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.240. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00054_B. EF_G_EF_2_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR009022. EFG_III-V.
IPR000640. EFG_V.
IPR027417. P-loop_NTPase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR004540. Transl_elong_EFG/EF2.
IPR005517. Transl_elong_EFG/EF2_IV.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PfamiPF00679. EFG_C. 1 hit.
PF14492. EFG_II. 1 hit.
PF03764. EFG_IV. 1 hit.
PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SMARTiSM00838. EFG_C. 1 hit.
SM00889. EFG_IV. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF54980. SSF54980. 2 hits.
TIGRFAMsiTIGR00484. EF-G. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiEFG_COXBU
AccessioniPrimary (citable) accession number: Q83ES7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: June 1, 2003
Last modified: January 7, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.