Q83EL7 (KGUA_COXBU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Guanylate kinase
EC=2.7.4.8

Alternative name(s):
GMP kinase

Gene names

Name:	gmk
Ordered Locus Names:	CBU_0301

Organism

Coxiella burnetii

Taxonomic identifier

777 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity. HAMAP MF_00328
Catalytic activity	ATP + GMP = ADP + GDP. HAMAP MF_00328
Subcellular location	Cytoplasm By similarity HAMAP MF_00328.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	purine nucleotide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW guanylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 206	206	Guanylate kinase HAMAP MF_00328		PRO_0000170530
Regions
	Domain	4 – 182	179	Guanylate kinase-like
	Nucleotide binding	11 – 18	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q83EL7 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 815BFEA7481A0D9C	FASTA	206	23,809
	10 20 30 40 50 60 MNKANLFIIS APSGAGKTSL VRALVKALAE IKISISHTTR PKRPGDQEGV DYFFIDETRF 70 80 90 100 110 120 QAMVKEGAFL EHATIYERHY GTEKDWVLRQ LKAGRDVLLE IDWQGARQIR ELFPPALSIF 130 140 150 160 170 180 ILPPSIEALR ERLIKRRQDD TAIIEQRLAL AREEMAHYKE FDYLVVNDNF DQAVQNLIHI 190 200 ISAERLQRDV QEKKLSRLLA ELVEKQ

References

[1]

"Complete genome sequence of the Q-fever pathogen, Coxiella burnetii." Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A. , Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E., Fraser C.M., Heidelberg J.F. Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed: 12704232] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nine Mile phase I / RSA 493.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE016828 Genomic DNA. Translation: AAO89858.1.

RefSeq

NP_819344.1. NC_002971.3.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3TR0	X-ray	1.85	A	1-202	[»]

ProteinModelPortal

Q83EL7.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

1208183.

GenomeReviews

Gene locus CBU_0301 in contig AE016828_GR.

KEGG

cbu:CBU_0301.

NMPDR

fig|227377.1.peg.288.

PATRIC

17929297. VBICoxBur82552_0296.

TIGR

CBU_0301.

Phylogenomic databases

HOGENOM

HBG671982.

OMA

DIDWQGT.

PhylomeDB

Q83EL7.

ProtClustDB

PRK00300.

Enzyme and pathway databases

BioCyc

CBUR227377:CBU_0301-MONOMER.

Family and domain databases

HAMAP

MF_00328. Guanylate_kinase.
[Tree]

InterPro

IPR008144. Guanylate_kin.
IPR008145. Guanylate_kin/L-typ_Ca_channel.
IPR020590. Guanylate_kinase_CS.
IPR017665. Guanylate_kinase_sub.
[Graphical view]

KO

K00942.

Pfam

PF00625. Guanylate_kin. 1 hit.
[Graphical view]

SMART

SM00072. GuKc. 1 hit.
[Graphical view]

TIGRFAMs

TIGR03263. Guanyl_kin. 1 hit.

PROSITE

PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

KGUA_COXBU

Accession

Primary (citable) accession number: Q83EL7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2004
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program