Q83EL0 (HTPG_COXBU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chaperone protein HtpG

Alternative name(s):
Heat shock protein HtpG
High temperature protein G

Gene names

Name:	htpG
Ordered Locus Names:	CBU_0309

Organism

Coxiella burnetii (strain RSA 493 / Nine Mile phase I) [Reference proteome] [HAMAP]

Taxonomic identifier

227377 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella › Coxiella burnetii

Protein attributes

Sequence length	633 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Molecular chaperone. Has ATPase activity By similarity. HAMAP-Rule MF_00505
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Developmental stage	More than twofold more abundant in the large cell variant (LCV) stage than in the small cell variant (SCV) stage (at protein level). LCVs are more metabolically active than SCVs. Ref.2
Sequence similarities	Belongs to the heat shock protein 90 family.
Sequence caution	The sequence AAO89866.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Stress response
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Chaperone
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein folding Inferred from electronic annotation. Source: HAMAP response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 633	633	Chaperone protein HtpG HAMAP-Rule MF_00505		PRO_0000062984
Regions
	Region	1 – 344	344	A; substrate-binding By similarity
	Region	345 – 560	216	B By similarity
	Region	561 – 633	73	C By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q83EL0 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: BC71210DD4B52271	FASTA	633	72,774
	10 20 30 40 50 60 MSLQPQAETL SFEAEVKQLL HLVAHSLYSN KEIFLRELIS NSSDAADKLR YQALSDAALY 70 80 90 100 110 120 ENDADLKIWI DFDKDNRTIT IRDNGIGMSR EEVIENLGTI AKSGTRAFRE LLAEKKAEDS 130 140 150 160 170 180 QLIGQFGVGF YSAFIVADRV VVRTRRAGMK ADQGVEWEST GEGEYTLKNI DKPTRGTEVV 190 200 210 220 230 240 LHLKESEEEF LDPLRLRAII TKYSDHILLP IVMKKIKTSG ADDEDKNETP EEEVVNRANA 250 260 270 280 290 300 LWVLPKDKIK DEEYKELYKH IAHDFEDPLA WVHNKVEGKL EYTTLLYIPA RAPFDLWNRE 310 320 330 340 350 360 GQRGLKLYVK RIFIMDDAEH FMPMYLRFVK GIVDSNDLPL NISRELLQSN EVINKIKAGC 370 380 390 400 410 420 VKRILSLLED LAKNDKEKYA SFWKAFGQVL KEGPAEDFAN RDRIANLLRF ASTHNDTDEQ 430 440 450 460 470 480 NVSLQDYISR MKPEQNKIYY IVADTYTSAK NSPLLEVFRK KDIEVLLMSD RVDEWLVAHL 490 500 510 520 530 540 NEFEGKSLQS IAKGTLDLGD LEKEEKVETE KFEKDFDELL KQFKEVLGEK IKDVRITHRL 550 560 570 580 590 600 TDSPTCVVFD ENEMSGHLQR LLIQTGQDFM QAKPILEINP SHPLILRVKN ESDKTRFNRW 610 620 630 ADLLLNQALL AEGEQLKDPA SFVKGLNELL LDS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of the Q-fever pathogen, Coxiella burnetii." Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A. , Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E., Fraser C.M., Heidelberg J.F. Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RSA 493 / Nine Mile phase I.
[2]	"Proteome and antigen profiling of Coxiella burnetii developmental forms." Coleman S.A., Fischer E.R., Cockrell D.C., Voth D.E., Howe D., Mead D.J., Samuel J.E., Heinzen R.A. Infect. Immun. 75:290-298(2007) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, DEVELOPMENTAL STAGE. Strain: Nine Mile Crazy / RSA 514.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016828 Genomic DNA. Translation: AAO89866.2. Different initiation.
RefSeq	NP_819352.2. NC_002971.3.
3D structure databases
ProteinModelPortal	Q83EL0.
SMR	Q83EL0. Positions 8-491.
ModBase	Search...
Protein-protein interaction databases
STRING	227377.CBU_0309.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAO89866; AAO89866; CBU_0309.
GeneID	1208191.
KEGG	cbu:CBU_0309.
PATRIC	17929309. VBICoxBur82552_0302.
Phylogenomic databases
eggNOG	COG0326.
HOGENOM	HOG000031989.
KO	K04079.
OMA	LTDSPAC.
ProtClustDB	PRK05218.
Enzyme and pathway databases
BioCyc	CBUR227377:GJ7S-316-MONOMER.
Family and domain databases
Gene3D	3.30.565.10. 1 hit.
HAMAP	MF_00505. HSP90.
InterPro	IPR003594. HATPase_ATP-bd. IPR019805. Heat_shock_protein_90_CS. IPR001404. Hsp90. IPR020575. Hsp90_N. IPR020568. Ribosomal_S5_D2-typ_fold. [Graphical view]
PANTHER	PTHR11528. PTHR11528. 1 hit.
Pfam	PF00183. HSP90. 1 hit. [Graphical view]
PIRSF	PIRSF002583. Hsp90. 1 hit.
PRINTS	PR00775. HEATSHOCK90.
SMART	SM00387. HATPase_c. 1 hit. [Graphical view]
SUPFAM	SSF55874. ATP_bd_ATPase. 1 hit. SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
PROSITE	PS00298. HSP90. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HTPG_COXBU

Accession

Primary (citable) accession number: Q83EL0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program