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Q83EL0

- HTPG_COXBU

UniProt

Q83EL0 - HTPG_COXBU

Protein

Chaperone protein HtpG

Gene

htpG

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Molecular chaperone. Has ATPase activity.UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. protein folding Source: UniProtKB-HAMAP
    2. response to stress Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Stress response

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCBUR227377:GJ7S-316-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chaperone protein HtpGUniRule annotation
    Alternative name(s):
    Heat shock protein HtpGUniRule annotation
    High temperature protein GUniRule annotation
    Gene namesi
    Name:htpGUniRule annotation
    Ordered Locus Names:CBU_0309
    OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
    Taxonomic identifieri227377 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
    ProteomesiUP000002671: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 633633Chaperone protein HtpGPRO_0000062984Add
    BLAST

    Expressioni

    Developmental stagei

    More than twofold more abundant in the large cell variant (LCV) stage than in the small cell variant (SCV) stage (at protein level). LCVs are more metabolically active than SCVs.1 Publication

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi227377.CBU_0309.

    Structurei

    3D structure databases

    ProteinModelPortaliQ83EL0.
    SMRiQ83EL0. Positions 8-491.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 344344A; substrate-bindingUniRule annotationAdd
    BLAST
    Regioni345 – 560216BUniRule annotationAdd
    BLAST
    Regioni561 – 63373CUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the heat shock protein 90 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0326.
    HOGENOMiHOG000031989.
    KOiK04079.
    OMAiMSHLTEF.
    OrthoDBiEOG65TRNM.

    Family and domain databases

    Gene3Di3.30.565.10. 1 hit.
    HAMAPiMF_00505. HSP90.
    InterProiIPR003594. HATPase_ATP-bd.
    IPR019805. Heat_shock_protein_90_CS.
    IPR001404. Hsp90_fam.
    IPR020575. Hsp90_N.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    [Graphical view]
    PANTHERiPTHR11528. PTHR11528. 1 hit.
    PfamiPF00183. HSP90. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002583. Hsp90. 1 hit.
    PRINTSiPR00775. HEATSHOCK90.
    SMARTiSM00387. HATPase_c. 1 hit.
    [Graphical view]
    SUPFAMiSSF54211. SSF54211. 1 hit.
    SSF55874. SSF55874. 1 hit.
    PROSITEiPS00298. HSP90. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q83EL0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLQPQAETL SFEAEVKQLL HLVAHSLYSN KEIFLRELIS NSSDAADKLR    50
    YQALSDAALY ENDADLKIWI DFDKDNRTIT IRDNGIGMSR EEVIENLGTI 100
    AKSGTRAFRE LLAEKKAEDS QLIGQFGVGF YSAFIVADRV VVRTRRAGMK 150
    ADQGVEWEST GEGEYTLKNI DKPTRGTEVV LHLKESEEEF LDPLRLRAII 200
    TKYSDHILLP IVMKKIKTSG ADDEDKNETP EEEVVNRANA LWVLPKDKIK 250
    DEEYKELYKH IAHDFEDPLA WVHNKVEGKL EYTTLLYIPA RAPFDLWNRE 300
    GQRGLKLYVK RIFIMDDAEH FMPMYLRFVK GIVDSNDLPL NISRELLQSN 350
    EVINKIKAGC VKRILSLLED LAKNDKEKYA SFWKAFGQVL KEGPAEDFAN 400
    RDRIANLLRF ASTHNDTDEQ NVSLQDYISR MKPEQNKIYY IVADTYTSAK 450
    NSPLLEVFRK KDIEVLLMSD RVDEWLVAHL NEFEGKSLQS IAKGTLDLGD 500
    LEKEEKVETE KFEKDFDELL KQFKEVLGEK IKDVRITHRL TDSPTCVVFD 550
    ENEMSGHLQR LLIQTGQDFM QAKPILEINP SHPLILRVKN ESDKTRFNRW 600
    ADLLLNQALL AEGEQLKDPA SFVKGLNELL LDS 633
    Length:633
    Mass (Da):72,774
    Last modified:June 1, 2003 - v1
    Checksum:iBC71210DD4B52271
    GO

    Sequence cautioni

    The sequence AAO89866.2 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO89866.2. Different initiation.
    RefSeqiNP_819352.2. NC_002971.3.

    Genome annotation databases

    EnsemblBacteriaiAAO89866; AAO89866; CBU_0309.
    GeneIDi1208191.
    KEGGicbu:CBU_0309.
    PATRICi17929309. VBICoxBur82552_0302.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO89866.2 . Different initiation.
    RefSeqi NP_819352.2. NC_002971.3.

    3D structure databases

    ProteinModelPortali Q83EL0.
    SMRi Q83EL0. Positions 8-491.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 227377.CBU_0309.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO89866 ; AAO89866 ; CBU_0309 .
    GeneIDi 1208191.
    KEGGi cbu:CBU_0309.
    PATRICi 17929309. VBICoxBur82552_0302.

    Phylogenomic databases

    eggNOGi COG0326.
    HOGENOMi HOG000031989.
    KOi K04079.
    OMAi MSHLTEF.
    OrthoDBi EOG65TRNM.

    Enzyme and pathway databases

    BioCyci CBUR227377:GJ7S-316-MONOMER.

    Family and domain databases

    Gene3Di 3.30.565.10. 1 hit.
    HAMAPi MF_00505. HSP90.
    InterProi IPR003594. HATPase_ATP-bd.
    IPR019805. Heat_shock_protein_90_CS.
    IPR001404. Hsp90_fam.
    IPR020575. Hsp90_N.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    [Graphical view ]
    PANTHERi PTHR11528. PTHR11528. 1 hit.
    Pfami PF00183. HSP90. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002583. Hsp90. 1 hit.
    PRINTSi PR00775. HEATSHOCK90.
    SMARTi SM00387. HATPase_c. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54211. SSF54211. 1 hit.
    SSF55874. SSF55874. 1 hit.
    PROSITEi PS00298. HSP90. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RSA 493 / Nine Mile phase I.
    2. "Proteome and antigen profiling of Coxiella burnetii developmental forms."
      Coleman S.A., Fischer E.R., Cockrell D.C., Voth D.E., Howe D., Mead D.J., Samuel J.E., Heinzen R.A.
      Infect. Immun. 75:290-298(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, DEVELOPMENTAL STAGE.
      Strain: Nine Mile Crazy / RSA 514.

    Entry informationi

    Entry nameiHTPG_COXBU
    AccessioniPrimary (citable) accession number: Q83EL0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Coxiella burnetii
      Coxiella burnetii (strain RSA 493): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3