ID OMP1_COXBU Reviewed; 252 AA. AC Q83EK8; Q841J3; Q841J4; Q8KQK0; DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot. DT 05-FEB-2008, sequence version 2. DT 27-MAR-2024, entry version 89. DE RecName: Full=Outer membrane protein P1; DE Flags: Precursor; GN Name=ompP1; OrderedLocusNames=CBU_0311; OS Coxiella burnetii (strain RSA 493 / Nine Mile phase I). OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales; Coxiellaceae; OC Coxiella. OX NCBI_TaxID=227377; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 24-43 AND 188-199, RP SUBCELLULAR LOCATION, SUBUNIT, AND ION CONDUCTANCE. RC STRAIN=Kerns, Koka, RSA 493 / Nine Mile phase I, and Scurry; RX PubMed=12438349; DOI=10.1128/iai.70.12.6741-6750.2002; RA Varghees S., Kiss K., Frans G., Braha O., Samuel J.E.; RT "Cloning and porin activity of the major outer membrane protein P1 from RT Coxiella burnetii."; RL Infect. Immun. 70:6741-6750(2002). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=Henzerling, and Xinqiao; RA Wei W., Wen B.; RT "Cloning and expression of major outer membrane protein P1 gene of Coxiella RT burnetii in Escherichia coli."; RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=RSA 493 / Nine Mile phase I; RX PubMed=12704232; DOI=10.1073/pnas.0931379100; RA Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., RA Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., RA Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., RA Lee K.H., Carty H.A., Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E., RA Fraser C.M., Heidelberg J.F.; RT "Complete genome sequence of the Q-fever pathogen, Coxiella burnetii."; RL Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003). RN [4] RP BIOTECHNOLOGY. RX PubMed=16481504; DOI=10.1196/annals.1355.021; RA Li Q., Niu D., Wen B., Chen M., Qiu L., Zhang J.; RT "Protective immunity against Q fever induced with a recombinant P1 antigen RT fused with HspB of Coxiella burnetii."; RL Ann. N. Y. Acad. Sci. 1063:130-142(2005). CC -!- FUNCTION: Able to form a pore in lipid bilayers. CC -!- SUBUNIT: May form trimers. {ECO:0000269|PubMed:12438349}. CC -!- SUBCELLULAR LOCATION: Cell outer membrane CC {ECO:0000269|PubMed:12438349}; Multi-pass membrane protein CC {ECO:0000269|PubMed:12438349}. Note=Outer membrane location shown for CC Nine Mile phase I, but not that it actually spans the membrane. CC -!- DEVELOPMENTAL STAGE: Found in the large cell variant (LCV) stage, very CC little is present in the small cell variant (SCV) stage (at protein CC level). LCVs are more metabolically active than SCVs. CC -!- BIOTECHNOLOGY: Might be used for vaccine production. CC {ECO:0000269|PubMed:16481504}. CC -!- SIMILARITY: Belongs to the Coxiella porin P1 (CPP1) (TC 1.B.43) family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY082614; AAM03442.1; -; Genomic_DNA. DR EMBL; AY249912; AAP04426.1; -; Genomic_DNA. DR EMBL; AY249911; AAP04425.1; -; Genomic_DNA. DR EMBL; AE016828; AAO89868.2; -; Genomic_DNA. DR RefSeq; NP_819354.2; NC_002971.3. DR RefSeq; WP_010957496.1; NC_002971.4. DR AlphaFoldDB; Q83EK8; -. DR STRING; 227377.CBU_0311; -. DR TCDB; 1.B.43.1.1; the coxiella porin p1 (cpp1) family. DR EnsemblBacteria; AAO89868; AAO89868; CBU_0311. DR GeneID; 1208193; -. DR KEGG; cbu:CBU_0311; -. DR PATRIC; fig|227377.7.peg.303; -. DR eggNOG; COG3637; Bacteria. DR HOGENOM; CLU_1238523_0_0_6; -. DR Proteomes; UP000002671; Chromosome. DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell. DR GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW. DR GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW. DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW. DR InterPro; IPR011250; OMP/PagP_b-brl. DR SUPFAM; SSF56925; OMPA-like; 1. PE 1: Evidence at protein level; KW Cell outer membrane; Direct protein sequencing; Ion transport; Membrane; KW Pharmaceutical; Porin; Reference proteome; Signal; Transmembrane; KW Transmembrane beta strand; Transport. FT SIGNAL 1..23 FT /evidence="ECO:0000269|PubMed:12438349" FT CHAIN 24..252 FT /note="Outer membrane protein P1" FT /id="PRO_0000318560" FT VARIANT 17 FT /note="L -> F (in strain: Henzerling)" FT VARIANT 33 FT /note="M -> L (in strain: Henzerling)" FT VARIANT 60 FT /note="N -> D (in strain: Kerns)" FT VARIANT 78 FT /note="F -> S (in strain: Xinqiao)" FT VARIANT 79 FT /note="G -> S (in strain: Kerns)" FT VARIANT 115 FT /note="P -> S (in strain: Scurry)" FT VARIANT 120..122 FT /note="NYS -> T (in strain: Kerns and Scurry)" FT VARIANT 125 FT /note="T -> I (in strain: Xinqiao)" FT VARIANT 127 FT /note="L -> T (in strain: Kerns)" FT VARIANT 131 FT /note="L -> F (in strain: Xinqiao)" FT VARIANT 136 FT /note="L -> I (in strain: Kerns)" FT VARIANT 147..148 FT /note="VY -> DD (in strain: Kerns)" FT VARIANT 151..152 FT /note="AG -> SE (in strain: Kerns)" FT VARIANT 168..171 FT /note="VAVS -> GPVG (in strain: Kerns)" FT VARIANT 172 FT /note="M -> I (in strain: Xinqiao)" FT VARIANT 176 FT /note="L -> M (in strain: Kerns)" FT VARIANT 222..223 FT /note="GT -> EA (in strain: Kerns and Scurry)" FT VARIANT 228 FT /note="S -> L (in strain: Kerns and Scurry)" FT CONFLICT 192 FT /note="N -> I (in Ref. 1; AA sequence)" FT /evidence="ECO:0000305" FT CONFLICT 199 FT /note="Y -> D (in Ref. 1; AA sequence)" FT /evidence="ECO:0000305" SQ SEQUENCE 252 AA; 26771 MW; 577ED12852666E18 CRC64; METTTKLAIG VSALCCLASA AFAGGPDIPM IDMNGFHIGL GFGYKSYTYD QVGTVTVTTN GGTVLSVLHP VSASITQFGP VGELGYTFAS DWWIAGVKAQ YQYDNVRSVH IMDAPLVGSN YSYRTRLGSH LTAMLLAGIK VNEANAVYLE AGYSTVWGKT TLFGPGPVAV SMKNRLNGGI AGIGWRHYFM NNVFLDLSYD YALYRSKSNS VTLSSATASA EGTAIGVSGT VQNPKRVAIN GITATVNYLF NI //