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Q83EK8 (OMP1_COXBU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Outer membrane protein P1
Gene names
Name:ompP1
Ordered Locus Names:CBU_0311
OrganismCoxiella burnetii (strain RSA 493 / Nine Mile phase I) [Reference proteome] [HAMAP]
Taxonomic identifier227377 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella

Protein attributes

Sequence length252 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Able to form a pore in lipid bilayers.

Subunit structure

May form trimers. Ref.1

Subcellular location

Cell outer membrane; Multi-pass membrane protein. Note: Outer membrane location shown for Nine Mile phase I, but not that it actually spans the membrane. Ref.1

Developmental stage

Found in the large cell variant (LCV) stage, very little is present in the small cell variant (SCV) stage (at protein level). LCVs are more metabolically active than SCVs.

Biotechnological use

Might be used for vaccine production. Ref.4

Sequence similarities

Belongs to the Coxiella porin P1 (CPP1) (TC 1.B.43) family. [View classification]

Ontologies

Keywords
   Biological processIon transport
Transport
   Cellular componentCell outer membrane
Membrane
   DomainSignal
Transmembrane
Transmembrane beta strand
   Molecular functionPorin
   Technical termComplete proteome
Direct protein sequencing
Pharmaceutical
Reference proteome
Gene Ontology (GO)
   Biological_procession transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcell outer membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

pore complex

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionporin activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Ref.1
Chain24 – 252229Outer membrane protein P1
PRO_0000318560

Natural variations

Natural variant171L → F in strain: Henzerling.
Natural variant331M → L in strain: Henzerling.
Natural variant601N → D in strain: Kerns.
Natural variant781F → S in strain: Xinqiao.
Natural variant791G → S in strain: Kerns.
Natural variant1151P → S in strain: Scurry.
Natural variant120 – 1223NYS → T in strain: Kerns and Scurry.
Natural variant1251T → I in strain: Xinqiao.
Natural variant1271L → T in strain: Kerns.
Natural variant1311L → F in strain: Xinqiao.
Natural variant1361L → I in strain: Kerns.
Natural variant147 – 1482VY → DD in strain: Kerns.
Natural variant151 – 1522AG → SE in strain: Kerns.
Natural variant168 – 1714VAVS → GPVG in strain: Kerns.
Natural variant1721M → I in strain: Xinqiao.
Natural variant1761L → M in strain: Kerns.
Natural variant222 – 2232GT → EA in strain: Kerns and Scurry.
Natural variant2281S → L in strain: Kerns and Scurry.

Experimental info

Sequence conflict1921N → I AA sequence Ref.1
Sequence conflict1991Y → D AA sequence Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q83EK8 [UniParc].

Last modified February 5, 2008. Version 2.
Checksum: 577ED12852666E18

FASTA25226,771
        10         20         30         40         50         60 
METTTKLAIG VSALCCLASA AFAGGPDIPM IDMNGFHIGL GFGYKSYTYD QVGTVTVTTN 

        70         80         90        100        110        120 
GGTVLSVLHP VSASITQFGP VGELGYTFAS DWWIAGVKAQ YQYDNVRSVH IMDAPLVGSN 

       130        140        150        160        170        180 
YSYRTRLGSH LTAMLLAGIK VNEANAVYLE AGYSTVWGKT TLFGPGPVAV SMKNRLNGGI 

       190        200        210        220        230        240 
AGIGWRHYFM NNVFLDLSYD YALYRSKSNS VTLSSATASA EGTAIGVSGT VQNPKRVAIN 

       250 
GITATVNYLF NI 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and porin activity of the major outer membrane protein P1 from Coxiella burnetii."
Varghees S., Kiss K., Frans G., Braha O., Samuel J.E.
Infect. Immun. 70:6741-6750(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 24-43 AND 188-199, SUBCELLULAR LOCATION, SUBUNIT, ION CONDUCTANCE.
Strain: Kerns, Koka, RSA 493 / Nine Mile phase I and Scurry.
[2]"Cloning and expresion of major outer membrane protein P1 gene of Coxiella burnetii in Escherichia coli."
Wei W., Wen B.
Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Henzerling and Xinqiao.
[3]"Complete genome sequence of the Q-fever pathogen, Coxiella burnetii."
Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A. expand/collapse author list , Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E., Fraser C.M., Heidelberg J.F.
Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RSA 493 / Nine Mile phase I.
[4]"Protective immunity against Q fever induced with a recombinant P1 antigen fused with HspB of Coxiella burnetii."
Li Q., Niu D., Wen B., Chen M., Qiu L., Zhang J.
Ann. N. Y. Acad. Sci. 1063:130-142(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: BIOTECHNOLOGY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY082614 Genomic DNA. Translation: AAM03442.1.
AY249912 Genomic DNA. Translation: AAP04426.1.
AY249911 Genomic DNA. Translation: AAP04425.1.
AE016828 Genomic DNA. Translation: AAO89868.2.
RefSeqNP_819354.2. NC_002971.3.

3D structure databases

ProteinModelPortalQ83EK8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING227377.CBU_0311.

Protein family/group databases

TCDB1.B.43.1.1. the coxiella porin p1 (cpp1) family.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO89868; AAO89868; CBU_0311.
GeneID1208193.
KEGGcbu:CBU_0311.
PATRIC17929311. VBICoxBur82552_0303.

Phylogenomic databases

eggNOGbactNOG91592.
HOGENOMHOG000027311.
OMAHIMDAHS.
OrthoDBEOG6G7R25.
ProtClustDBCLSK913977.

Enzyme and pathway databases

BioCycCBUR227377:GJ7S-317-MONOMER.

Family and domain databases

Gene3D2.40.160.20. 1 hit.
InterProIPR011250. OMP/PagP_b-brl.
IPR027385. OMP_b-brl.
[Graphical view]
PfamPF13505. OMP_b-brl. 1 hit.
[Graphical view]
SUPFAMSSF56925. SSF56925. 2 hits.
ProtoNetSearch...

Entry information

Entry nameOMP1_COXBU
AccessionPrimary (citable) accession number: Q83EK8
Secondary accession number(s): Q841J3, Q841J4, Q8KQK0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: April 16, 2014
This is version 58 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Coxiella burnetii

Coxiella burnetii (strain RSA 493): entries and gene names