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Q83EK8

- OMP1_COXBU

UniProt

Q83EK8 - OMP1_COXBU

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Protein

Outer membrane protein P1

Gene

ompP1

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Able to form a pore in lipid bilayers.

GO - Molecular functioni

  1. porin activity Source: UniProtKB-KW

GO - Biological processi

  1. ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Porin

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-317-MONOMER.

Protein family/group databases

TCDBi1.B.43.1.1. the coxiella porin p1 (cpp1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Outer membrane protein P1
Gene namesi
Name:ompP1
Ordered Locus Names:CBU_0311
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671: Chromosome

Subcellular locationi

Cell outer membrane 1 Publication; Multi-pass membrane protein 1 Publication
Note: Outer membrane location shown for Nine Mile phase I, but not that it actually spans the membrane.

GO - Cellular componenti

  1. cell outer membrane Source: UniProtKB-KW
  2. pore complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

Pathology & Biotechi

Biotechnological usei

Might be used for vaccine production.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 PublicationAdd
BLAST
Chaini24 – 252229Outer membrane protein P1PRO_0000318560Add
BLAST

Expressioni

Developmental stagei

Found in the large cell variant (LCV) stage, very little is present in the small cell variant (SCV) stage (at protein level). LCVs are more metabolically active than SCVs.

Interactioni

Subunit structurei

May form trimers.1 Publication

Protein-protein interaction databases

STRINGi227377.CBU_0311.

Structurei

3D structure databases

ProteinModelPortaliQ83EK8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGibactNOG91592.
HOGENOMiHOG000027311.
OMAiHIMDAHS.
OrthoDBiEOG6G7R25.

Family and domain databases

Gene3Di2.40.160.20. 1 hit.
InterProiIPR011250. OMP/PagP_b-brl.
IPR027385. OMP_b-brl.
[Graphical view]
PfamiPF13505. OMP_b-brl. 1 hit.
[Graphical view]
SUPFAMiSSF56925. SSF56925. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q83EK8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
METTTKLAIG VSALCCLASA AFAGGPDIPM IDMNGFHIGL GFGYKSYTYD
60 70 80 90 100
QVGTVTVTTN GGTVLSVLHP VSASITQFGP VGELGYTFAS DWWIAGVKAQ
110 120 130 140 150
YQYDNVRSVH IMDAPLVGSN YSYRTRLGSH LTAMLLAGIK VNEANAVYLE
160 170 180 190 200
AGYSTVWGKT TLFGPGPVAV SMKNRLNGGI AGIGWRHYFM NNVFLDLSYD
210 220 230 240 250
YALYRSKSNS VTLSSATASA EGTAIGVSGT VQNPKRVAIN GITATVNYLF

NI
Length:252
Mass (Da):26,771
Last modified:February 5, 2008 - v2
Checksum:i577ED12852666E18
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti192 – 1921N → I AA sequence (PubMed:12438349)Curated
Sequence conflicti199 – 1991Y → D AA sequence (PubMed:12438349)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti17 – 171L → F in strain: Henzerling.
Natural varianti33 – 331M → L in strain: Henzerling.
Natural varianti60 – 601N → D in strain: Kerns.
Natural varianti78 – 781F → S in strain: Xinqiao.
Natural varianti79 – 791G → S in strain: Kerns.
Natural varianti115 – 1151P → S in strain: Scurry.
Natural varianti120 – 1223NYS → T in strain: Kerns and Scurry.
Natural varianti125 – 1251T → I in strain: Xinqiao.
Natural varianti127 – 1271L → T in strain: Kerns.
Natural varianti131 – 1311L → F in strain: Xinqiao.
Natural varianti136 – 1361L → I in strain: Kerns.
Natural varianti147 – 1482VY → DD in strain: Kerns.
Natural varianti151 – 1522AG → SE in strain: Kerns.
Natural varianti168 – 1714VAVS → GPVG in strain: Kerns.
Natural varianti172 – 1721M → I in strain: Xinqiao.
Natural varianti176 – 1761L → M in strain: Kerns.
Natural varianti222 – 2232GT → EA in strain: Kerns and Scurry.
Natural varianti228 – 2281S → L in strain: Kerns and Scurry.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY082614 Genomic DNA. Translation: AAM03442.1.
AY249912 Genomic DNA. Translation: AAP04426.1.
AY249911 Genomic DNA. Translation: AAP04425.1.
AE016828 Genomic DNA. Translation: AAO89868.2.
RefSeqiNP_819354.2. NC_002971.3.
WP_010957496.1. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO89868; AAO89868; CBU_0311.
GeneIDi1208193.
KEGGicbu:CBU_0311.
PATRICi17929311. VBICoxBur82552_0303.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY082614 Genomic DNA. Translation: AAM03442.1 .
AY249912 Genomic DNA. Translation: AAP04426.1 .
AY249911 Genomic DNA. Translation: AAP04425.1 .
AE016828 Genomic DNA. Translation: AAO89868.2 .
RefSeqi NP_819354.2. NC_002971.3.
WP_010957496.1. NC_002971.3.

3D structure databases

ProteinModelPortali Q83EK8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227377.CBU_0311.

Protein family/group databases

TCDBi 1.B.43.1.1. the coxiella porin p1 (cpp1) family.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO89868 ; AAO89868 ; CBU_0311 .
GeneIDi 1208193.
KEGGi cbu:CBU_0311.
PATRICi 17929311. VBICoxBur82552_0303.

Phylogenomic databases

eggNOGi bactNOG91592.
HOGENOMi HOG000027311.
OMAi HIMDAHS.
OrthoDBi EOG6G7R25.

Enzyme and pathway databases

BioCyci CBUR227377:GJ7S-317-MONOMER.

Family and domain databases

Gene3Di 2.40.160.20. 1 hit.
InterProi IPR011250. OMP/PagP_b-brl.
IPR027385. OMP_b-brl.
[Graphical view ]
Pfami PF13505. OMP_b-brl. 1 hit.
[Graphical view ]
SUPFAMi SSF56925. SSF56925. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and porin activity of the major outer membrane protein P1 from Coxiella burnetii."
    Varghees S., Kiss K., Frans G., Braha O., Samuel J.E.
    Infect. Immun. 70:6741-6750(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 24-43 AND 188-199, SUBCELLULAR LOCATION, SUBUNIT, ION CONDUCTANCE.
    Strain: Kerns, Koka, RSA 493 / Nine Mile phase I and Scurry.
  2. "Cloning and expresion of major outer membrane protein P1 gene of Coxiella burnetii in Escherichia coli."
    Wei W., Wen B.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Henzerling and Xinqiao.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.
  4. "Protective immunity against Q fever induced with a recombinant P1 antigen fused with HspB of Coxiella burnetii."
    Li Q., Niu D., Wen B., Chen M., Qiu L., Zhang J.
    Ann. N. Y. Acad. Sci. 1063:130-142(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: BIOTECHNOLOGY.

Entry informationi

Entry nameiOMP1_COXBU
AccessioniPrimary (citable) accession number: Q83EK8
Secondary accession number(s): Q841J3, Q841J4, Q8KQK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: October 29, 2014
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3