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Q83EK8

- OMP1_COXBU

UniProt

Q83EK8 - OMP1_COXBU

Protein

Outer membrane protein P1

Gene

ompP1

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 2 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Able to form a pore in lipid bilayers.

    GO - Molecular functioni

    1. porin activity Source: UniProtKB-KW

    GO - Biological processi

    1. ion transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Porin

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    BioCyciCBUR227377:GJ7S-317-MONOMER.

    Protein family/group databases

    TCDBi1.B.43.1.1. the coxiella porin p1 (cpp1) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Outer membrane protein P1
    Gene namesi
    Name:ompP1
    Ordered Locus Names:CBU_0311
    OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
    Taxonomic identifieri227377 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
    ProteomesiUP000002671: Chromosome

    Subcellular locationi

    Cell outer membrane 1 Publication; Multi-pass membrane protein 1 Publication
    Note: Outer membrane location shown for Nine Mile phase I, but not that it actually spans the membrane.

    GO - Cellular componenti

    1. cell outer membrane Source: UniProtKB-SubCell
    2. pore complex Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell outer membrane, Membrane

    Pathology & Biotechi

    Biotechnological usei

    Might be used for vaccine production.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 23231 PublicationAdd
    BLAST
    Chaini24 – 252229Outer membrane protein P1PRO_0000318560Add
    BLAST

    Expressioni

    Developmental stagei

    Found in the large cell variant (LCV) stage, very little is present in the small cell variant (SCV) stage (at protein level). LCVs are more metabolically active than SCVs.

    Interactioni

    Subunit structurei

    May form trimers.1 Publication

    Protein-protein interaction databases

    STRINGi227377.CBU_0311.

    Structurei

    3D structure databases

    ProteinModelPortaliQ83EK8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane beta strand

    Phylogenomic databases

    eggNOGibactNOG91592.
    HOGENOMiHOG000027311.
    OMAiHIMDAHS.
    OrthoDBiEOG6G7R25.

    Family and domain databases

    Gene3Di2.40.160.20. 1 hit.
    InterProiIPR011250. OMP/PagP_b-brl.
    IPR027385. OMP_b-brl.
    [Graphical view]
    PfamiPF13505. OMP_b-brl. 1 hit.
    [Graphical view]
    SUPFAMiSSF56925. SSF56925. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q83EK8-1 [UniParc]FASTAAdd to Basket

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    METTTKLAIG VSALCCLASA AFAGGPDIPM IDMNGFHIGL GFGYKSYTYD    50
    QVGTVTVTTN GGTVLSVLHP VSASITQFGP VGELGYTFAS DWWIAGVKAQ 100
    YQYDNVRSVH IMDAPLVGSN YSYRTRLGSH LTAMLLAGIK VNEANAVYLE 150
    AGYSTVWGKT TLFGPGPVAV SMKNRLNGGI AGIGWRHYFM NNVFLDLSYD 200
    YALYRSKSNS VTLSSATASA EGTAIGVSGT VQNPKRVAIN GITATVNYLF 250
    NI 252
    Length:252
    Mass (Da):26,771
    Last modified:February 5, 2008 - v2
    Checksum:i577ED12852666E18
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti192 – 1921N → I AA sequence (PubMed:12438349)Curated
    Sequence conflicti199 – 1991Y → D AA sequence (PubMed:12438349)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti17 – 171L → F in strain: Henzerling.
    Natural varianti33 – 331M → L in strain: Henzerling.
    Natural varianti60 – 601N → D in strain: Kerns.
    Natural varianti78 – 781F → S in strain: Xinqiao.
    Natural varianti79 – 791G → S in strain: Kerns.
    Natural varianti115 – 1151P → S in strain: Scurry.
    Natural varianti120 – 1223NYS → T in strain: Kerns and Scurry.
    Natural varianti125 – 1251T → I in strain: Xinqiao.
    Natural varianti127 – 1271L → T in strain: Kerns.
    Natural varianti131 – 1311L → F in strain: Xinqiao.
    Natural varianti136 – 1361L → I in strain: Kerns.
    Natural varianti147 – 1482VY → DD in strain: Kerns.
    Natural varianti151 – 1522AG → SE in strain: Kerns.
    Natural varianti168 – 1714VAVS → GPVG in strain: Kerns.
    Natural varianti172 – 1721M → I in strain: Xinqiao.
    Natural varianti176 – 1761L → M in strain: Kerns.
    Natural varianti222 – 2232GT → EA in strain: Kerns and Scurry.
    Natural varianti228 – 2281S → L in strain: Kerns and Scurry.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY082614 Genomic DNA. Translation: AAM03442.1.
    AY249912 Genomic DNA. Translation: AAP04426.1.
    AY249911 Genomic DNA. Translation: AAP04425.1.
    AE016828 Genomic DNA. Translation: AAO89868.2.
    RefSeqiNP_819354.2. NC_002971.3.
    WP_010957496.1. NC_002971.3.

    Genome annotation databases

    EnsemblBacteriaiAAO89868; AAO89868; CBU_0311.
    GeneIDi1208193.
    KEGGicbu:CBU_0311.
    PATRICi17929311. VBICoxBur82552_0303.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY082614 Genomic DNA. Translation: AAM03442.1 .
    AY249912 Genomic DNA. Translation: AAP04426.1 .
    AY249911 Genomic DNA. Translation: AAP04425.1 .
    AE016828 Genomic DNA. Translation: AAO89868.2 .
    RefSeqi NP_819354.2. NC_002971.3.
    WP_010957496.1. NC_002971.3.

    3D structure databases

    ProteinModelPortali Q83EK8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 227377.CBU_0311.

    Protein family/group databases

    TCDBi 1.B.43.1.1. the coxiella porin p1 (cpp1) family.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO89868 ; AAO89868 ; CBU_0311 .
    GeneIDi 1208193.
    KEGGi cbu:CBU_0311.
    PATRICi 17929311. VBICoxBur82552_0303.

    Phylogenomic databases

    eggNOGi bactNOG91592.
    HOGENOMi HOG000027311.
    OMAi HIMDAHS.
    OrthoDBi EOG6G7R25.

    Enzyme and pathway databases

    BioCyci CBUR227377:GJ7S-317-MONOMER.

    Family and domain databases

    Gene3Di 2.40.160.20. 1 hit.
    InterProi IPR011250. OMP/PagP_b-brl.
    IPR027385. OMP_b-brl.
    [Graphical view ]
    Pfami PF13505. OMP_b-brl. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56925. SSF56925. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and porin activity of the major outer membrane protein P1 from Coxiella burnetii."
      Varghees S., Kiss K., Frans G., Braha O., Samuel J.E.
      Infect. Immun. 70:6741-6750(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 24-43 AND 188-199, SUBCELLULAR LOCATION, SUBUNIT, ION CONDUCTANCE.
      Strain: Kerns, Koka, RSA 493 / Nine Mile phase I and Scurry.
    2. "Cloning and expresion of major outer membrane protein P1 gene of Coxiella burnetii in Escherichia coli."
      Wei W., Wen B.
      Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Henzerling and Xinqiao.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RSA 493 / Nine Mile phase I.
    4. "Protective immunity against Q fever induced with a recombinant P1 antigen fused with HspB of Coxiella burnetii."
      Li Q., Niu D., Wen B., Chen M., Qiu L., Zhang J.
      Ann. N. Y. Acad. Sci. 1063:130-142(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: BIOTECHNOLOGY.

    Entry informationi

    Entry nameiOMP1_COXBU
    AccessioniPrimary (citable) accession number: Q83EK8
    Secondary accession number(s): Q841J3, Q841J4, Q8KQK0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 61 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome

    Documents

    1. Coxiella burnetii
      Coxiella burnetii (strain RSA 493): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3