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Q83EK7

- FOLD_COXBU

UniProt

Q83EK7 - FOLD_COXBU

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Protein

Bifunctional protein FolD

Gene

folD

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH.UniRule annotation
5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi166 – 1683NADPUniRule annotation

GO - Molecular functioni

  1. methenyltetrahydrofolate cyclohydrolase activity Source: UniProtKB-HAMAP
  2. methylenetetrahydrofolate dehydrogenase (NADP+) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. histidine biosynthetic process Source: UniProtKB-KW
  3. methionine biosynthetic process Source: UniProtKB-KW
  4. purine nucleotide biosynthetic process Source: UniProtKB-KW
  5. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis, Methionine biosynthesis, One-carbon metabolism, Purine biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-318-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein FolDUniRule annotation
Including the following 2 domains:
Methylenetetrahydrofolate dehydrogenaseUniRule annotation (EC:1.5.1.5UniRule annotation)
Methenyltetrahydrofolate cyclohydrolaseUniRule annotation (EC:3.5.4.9UniRule annotation)
Gene namesi
Name:folDUniRule annotation
Ordered Locus Names:CBU_0312
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 283283Bifunctional protein FolDPRO_0000268327Add
BLAST

Proteomic databases

PRIDEiQ83EK7.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi227377.CBU_0312.

Structurei

3D structure databases

ProteinModelPortaliQ83EK7.
SMRiQ83EK7. Positions 3-278.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0190.
HOGENOMiHOG000218242.
KOiK01491.
OMAiCHSKSIY.
OrthoDBiEOG6K6VBB.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01576. THF_DHG_CYH.
InterProiIPR016040. NAD(P)-bd_dom.
IPR000672. THF_DH/CycHdrlase.
IPR020630. THF_DH/CycHdrlase_cat_dom.
IPR020867. THF_DH/CycHdrlase_CS.
IPR020631. THF_DH/CycHdrlase_NAD-bd_dom.
[Graphical view]
PfamiPF00763. THF_DHG_CYH. 1 hit.
PF02882. THF_DHG_CYH_C. 1 hit.
[Graphical view]
PRINTSiPR00085. THFDHDRGNASE.
PROSITEiPS00767. THF_DHG_CYH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q83EK7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIARILDGRT CAEKVKARVK ENIRLLQEKG LPSPGLAVIL VGNDPASATY
60 70 80 90 100
VAHKERACQA VGIRSTVYRM PNTITESELA SKIDECNRDS NTHGILLQLP
110 120 130 140 150
LPAHIDPANL LERIRPDKDV DGFHPYNLGR LVQRRPALRP CTPYGVMTLL
160 170 180 190 200
TETHENLEGK HAVIVGASNI VGRPMALELL LAKCTVTVCH RFTRDLAEHV
210 220 230 240 250
KSAELLIVAI GKPGIIQSEW IKPGAIVIDV GFSRLSPNKI AGDIDFETAK
260 270 280
ERASWITPVP GGVGPMTVAT LLENTLQAAQ TFL
Length:283
Mass (Da):30,820
Last modified:June 1, 2003 - v1
Checksum:iAA81B2B09EE7A2B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO89869.1.
RefSeqiNP_819355.1. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO89869; AAO89869; CBU_0312.
GeneIDi1208194.
KEGGicbu:CBU_0312.
PATRICi17929313. VBICoxBur82552_0304.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO89869.1 .
RefSeqi NP_819355.1. NC_002971.3.

3D structure databases

ProteinModelPortali Q83EK7.
SMRi Q83EK7. Positions 3-278.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227377.CBU_0312.

Proteomic databases

PRIDEi Q83EK7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO89869 ; AAO89869 ; CBU_0312 .
GeneIDi 1208194.
KEGGi cbu:CBU_0312.
PATRICi 17929313. VBICoxBur82552_0304.

Phylogenomic databases

eggNOGi COG0190.
HOGENOMi HOG000218242.
KOi K01491.
OMAi CHSKSIY.
OrthoDBi EOG6K6VBB.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci CBUR227377:GJ7S-318-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01576. THF_DHG_CYH.
InterProi IPR016040. NAD(P)-bd_dom.
IPR000672. THF_DH/CycHdrlase.
IPR020630. THF_DH/CycHdrlase_cat_dom.
IPR020867. THF_DH/CycHdrlase_CS.
IPR020631. THF_DH/CycHdrlase_NAD-bd_dom.
[Graphical view ]
Pfami PF00763. THF_DHG_CYH. 1 hit.
PF02882. THF_DHG_CYH_C. 1 hit.
[Graphical view ]
PRINTSi PR00085. THFDHDRGNASE.
PROSITEi PS00767. THF_DHG_CYH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiFOLD_COXBU
AccessioniPrimary (citable) accession number: Q83EK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 1, 2003
Last modified: October 1, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3