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Q83EK7 (FOLD_COXBU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional protein FolD

Including the following 2 domains:

  1. Methylenetetrahydrofolate dehydrogenase
    EC=1.5.1.5
  2. Methenyltetrahydrofolate cyclohydrolase
    EC=3.5.4.9
Gene names
Name:folD
Ordered Locus Names:CBU_0312
OrganismCoxiella burnetii (strain RSA 493 / Nine Mile phase I) [Reference proteome] [HAMAP]
Taxonomic identifier227377 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella

Protein attributes

Sequence length283 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate By similarity. HAMAP-Rule MF_01576

Catalytic activity

5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH. HAMAP-Rule MF_01576

5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate. HAMAP-Rule MF_01576

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01576

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01576

Sequence similarities

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 283283Bifunctional protein FolD HAMAP-Rule MF_01576
PRO_0000268327

Regions

Nucleotide binding166 – 1683NADP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q83EK7 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: AA81B2B09EE7A2B2

FASTA28330,820
        10         20         30         40         50         60 
MIARILDGRT CAEKVKARVK ENIRLLQEKG LPSPGLAVIL VGNDPASATY VAHKERACQA 

        70         80         90        100        110        120 
VGIRSTVYRM PNTITESELA SKIDECNRDS NTHGILLQLP LPAHIDPANL LERIRPDKDV 

       130        140        150        160        170        180 
DGFHPYNLGR LVQRRPALRP CTPYGVMTLL TETHENLEGK HAVIVGASNI VGRPMALELL 

       190        200        210        220        230        240 
LAKCTVTVCH RFTRDLAEHV KSAELLIVAI GKPGIIQSEW IKPGAIVIDV GFSRLSPNKI 

       250        260        270        280 
AGDIDFETAK ERASWITPVP GGVGPMTVAT LLENTLQAAQ TFL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016828 Genomic DNA. Translation: AAO89869.1.
RefSeqNP_819355.1. NC_002971.3.

3D structure databases

ProteinModelPortalQ83EK7.
SMRQ83EK7. Positions 3-278.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING227377.CBU_0312.

Proteomic databases

PRIDEQ83EK7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO89869; AAO89869; CBU_0312.
GeneID1208194.
KEGGcbu:CBU_0312.
PATRIC17929313. VBICoxBur82552_0304.

Phylogenomic databases

eggNOGCOG0190.
HOGENOMHOG000218242.
KOK01491.
OMACHSKSIY.
OrthoDBEOG6K6VBB.

Enzyme and pathway databases

BioCycCBUR227377:GJ7S-318-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01576. THF_DHG_CYH.
InterProIPR016040. NAD(P)-bd_dom.
IPR000672. THF_DH/CycHdrlase.
IPR020630. THF_DH/CycHdrlase_cat_dom.
IPR020867. THF_DH/CycHdrlase_CS.
IPR020631. THF_DH/CycHdrlase_NAD-bd_dom.
[Graphical view]
PfamPF00763. THF_DHG_CYH. 1 hit.
PF02882. THF_DHG_CYH_C. 1 hit.
[Graphical view]
PRINTSPR00085. THFDHDRGNASE.
PROSITEPS00767. THF_DHG_CYH_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFOLD_COXBU
AccessionPrimary (citable) accession number: Q83EK7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Coxiella burnetii

Coxiella burnetii (strain RSA 493): entries and gene names