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Q83EC8 (LSPA_COXBU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lipoprotein signal peptidase

EC=3.4.23.36
Alternative name(s):
Prolipoprotein signal peptidase
Signal peptidase II
Short name=SPase II
Gene names
Name:lspA
Ordered Locus Names:CBU_0397
OrganismCoxiella burnetii (strain RSA 493 / Nine Mile phase I) [Reference proteome] [HAMAP]
Taxonomic identifier227377 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella

Protein attributes

Sequence length163 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This protein specifically catalyzes the removal of signal peptides from prolipoproteins By similarity. HAMAP-Rule MF_00161

Catalytic activity

Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains. HAMAP-Rule MF_00161

Pathway

Protein modification; lipoprotein biosynthesis (signal peptide cleavage). HAMAP-Rule MF_00161

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_00161.

Sequence similarities

Belongs to the peptidase A8 family.

Sequence caution

The sequence AAO89950.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 163163Lipoprotein signal peptidase HAMAP-Rule MF_00161
PRO_0000289372

Regions

Transmembrane9 – 2921Helical; Potential
Transmembrane42 – 6221Helical; Potential
Transmembrane67 – 8721Helical; Potential
Transmembrane93 – 11321Helical; Potential
Transmembrane137 – 15721Helical; Potential

Sites

Active site1141 By similarity
Active site1411 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q83EC8 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 5AA56349B297A288

FASTA16318,575
        10         20         30         40         50         60 
MVTKKSKKAW PWLWFSVLVI LLDQLSKYLA NHFLSLGHPV KILPFLNFTL NYNTGAAFSF 

        70         80         90        100        110        120 
LGTENGWQII FFAAISFVVS IFLILWLSRT SRSEIMMLLG LSLIIGGALG NFIDRLRWSY 

       130        140        150        160 
VTDFIDFHIK DWHFATFNVA DSAICVGVFL LIVHMLLTPS SKP 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016828 Genomic DNA. Translation: AAO89950.2. Different initiation.
RefSeqNP_819436.2. NC_002971.3.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING227377.CBU_0397.

Protein family/group databases

MEROPSA08.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO89950; AAO89950; CBU_0397.
GeneID1208280.
KEGGcbu:CBU_0397.
PATRIC17929489. VBICoxBur82552_0391.

Phylogenomic databases

eggNOGCOG0597.
HOGENOMHOG000096993.
KOK03101.
OMADFASKQW.
OrthoDBEOG6PGKBM.

Enzyme and pathway databases

BioCycCBUR227377:GJ7S-399-MONOMER.
UniPathwayUPA00665.

Family and domain databases

HAMAPMF_00161. LspA.
InterProIPR001872. Peptidase_A8.
[Graphical view]
PfamPF01252. Peptidase_A8. 1 hit.
[Graphical view]
PRINTSPR00781. LIPOSIGPTASE.
TIGRFAMsTIGR00077. lspA. 1 hit.
PROSITEPS00855. SPASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLSPA_COXBU
AccessionPrimary (citable) accession number: Q83EC8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

PATHWAY comments

Index of metabolic and biosynthesis pathways

Coxiella burnetii

Coxiella burnetii (strain RSA 493): entries and gene names