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Q83EC8

- LSPA_COXBU

UniProt

Q83EC8 - LSPA_COXBU

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Protein
Lipoprotein signal peptidase
Gene
lspA, CBU_0397
Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This protein specifically catalyzes the removal of signal peptides from prolipoproteins By similarity.UniRule annotation

Catalytic activityi

Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei114 – 1141 By similarity
Active sitei141 – 1411 By similarity

GO - Molecular functioni

  1. aspartic-type endopeptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Aspartyl protease, Hydrolase, Protease

    Enzyme and pathway databases

    BioCyciCBUR227377:GJ7S-399-MONOMER.
    UniPathwayiUPA00665.

    Protein family/group databases

    MEROPSiA08.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipoprotein signal peptidase (EC:3.4.23.36)
    Alternative name(s):
    Prolipoprotein signal peptidase
    Signal peptidase II
    Short name:
    SPase II
    Gene namesi
    Name:lspA
    Ordered Locus Names:CBU_0397
    OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
    Taxonomic identifieri227377 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
    ProteomesiUP000002671: Chromosome

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 2921Helical; Reviewed prediction
    Add
    BLAST
    Transmembranei42 – 6221Helical; Reviewed prediction
    Add
    BLAST
    Transmembranei67 – 8721Helical; Reviewed prediction
    Add
    BLAST
    Transmembranei93 – 11321Helical; Reviewed prediction
    Add
    BLAST
    Transmembranei137 – 15721Helical; Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 163163Lipoprotein signal peptidaseUniRule annotation
    PRO_0000289372Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi227377.CBU_0397.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase A8 family.

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0597.
    HOGENOMiHOG000096993.
    KOiK03101.
    OMAiDFASKQW.
    OrthoDBiEOG6PGKBM.

    Family and domain databases

    HAMAPiMF_00161. LspA.
    InterProiIPR001872. Peptidase_A8.
    [Graphical view]
    PfamiPF01252. Peptidase_A8. 1 hit.
    [Graphical view]
    PRINTSiPR00781. LIPOSIGPTASE.
    TIGRFAMsiTIGR00077. lspA. 1 hit.
    PROSITEiPS00855. SPASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q83EC8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVTKKSKKAW PWLWFSVLVI LLDQLSKYLA NHFLSLGHPV KILPFLNFTL    50
    NYNTGAAFSF LGTENGWQII FFAAISFVVS IFLILWLSRT SRSEIMMLLG 100
    LSLIIGGALG NFIDRLRWSY VTDFIDFHIK DWHFATFNVA DSAICVGVFL 150
    LIVHMLLTPS SKP 163
    Length:163
    Mass (Da):18,575
    Last modified:June 1, 2003 - v1
    Checksum:i5AA56349B297A288
    GO

    Sequence cautioni

    The sequence AAO89950.2 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO89950.2. Different initiation.
    RefSeqiNP_819436.2. NC_002971.3.

    Genome annotation databases

    EnsemblBacteriaiAAO89950; AAO89950; CBU_0397.
    GeneIDi1208280.
    KEGGicbu:CBU_0397.
    PATRICi17929489. VBICoxBur82552_0391.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO89950.2 . Different initiation.
    RefSeqi NP_819436.2. NC_002971.3.

    3D structure databases

    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 227377.CBU_0397.

    Protein family/group databases

    MEROPSi A08.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO89950 ; AAO89950 ; CBU_0397 .
    GeneIDi 1208280.
    KEGGi cbu:CBU_0397.
    PATRICi 17929489. VBICoxBur82552_0391.

    Phylogenomic databases

    eggNOGi COG0597.
    HOGENOMi HOG000096993.
    KOi K03101.
    OMAi DFASKQW.
    OrthoDBi EOG6PGKBM.

    Enzyme and pathway databases

    UniPathwayi UPA00665 .
    BioCyci CBUR227377:GJ7S-399-MONOMER.

    Family and domain databases

    HAMAPi MF_00161. LspA.
    InterProi IPR001872. Peptidase_A8.
    [Graphical view ]
    Pfami PF01252. Peptidase_A8. 1 hit.
    [Graphical view ]
    PRINTSi PR00781. LIPOSIGPTASE.
    TIGRFAMsi TIGR00077. lspA. 1 hit.
    PROSITEi PS00855. SPASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RSA 493 / Nine Mile phase I.

    Entry informationi

    Entry nameiLSPA_COXBU
    AccessioniPrimary (citable) accession number: Q83EC8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: June 1, 2003
    Last modified: May 14, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Coxiella burnetii
      Coxiella burnetii (strain RSA 493): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. Peptidase families
      Classification of peptidase families and list of entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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