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Q83E97

- SYK_COXBU

UniProt

Q83E97 - SYK_COXBU

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Protein

Lysine--tRNA ligase

Gene
lysS, CBU_0430
Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).UniRule annotation

Cofactori

Binds 3 magnesium ions per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi409 – 4091Magnesium 1 By similarity
Metal bindingi416 – 4161Magnesium 1 By similarity
Metal bindingi416 – 4161Magnesium 2 By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. lysine-tRNA ligase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. nucleic acid binding Source: InterPro

GO - Biological processi

  1. lysyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-428-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine--tRNA ligase (EC:6.1.1.6)
Alternative name(s):
Lysyl-tRNA synthetase
Short name:
LysRS
Gene namesi
Name:lysS
Ordered Locus Names:CBU_0430
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 498498Lysine--tRNA ligaseUniRule annotationPRO_0000152620Add
BLAST

Proteomic databases

PRIDEiQ83E97.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi227377.CBU_0430.

Structurei

3D structure databases

ProteinModelPortaliQ83E97.
SMRiQ83E97. Positions 7-497.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1190.
HOGENOMiHOG000236578.
KOiK04567.
OMAiAMHFDAD.
OrthoDBiEOG69PQ2M.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00252. Lys_tRNA_synth_class2.
InterProiIPR004364. aa-tRNA-synt_II.
IPR018150. aa-tRNA-synt_II-like.
IPR006195. aa-tRNA-synth_II.
IPR002313. Lys-tRNA-ligase_II.
IPR018149. Lys-tRNA-synth_II_C.
IPR012340. NA-bd_OB-fold.
IPR004365. NA-bd_OB_tRNA.
[Graphical view]
PANTHERiPTHR22594. PTHR22594. 1 hit.
PfamiPF00152. tRNA-synt_2. 1 hit.
PF01336. tRNA_anti-codon. 1 hit.
[Graphical view]
PRINTSiPR00982. TRNASYNTHLYS.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00499. lysS_bact. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q83E97-1 [UniParc]FASTAAdd to Basket

« Hide

MELKDQIKEE NEQIAQRKLK LKKRREEGQA YPNDFKRDSL AADLHAVYDQ    50
FDSGALTAKA IRVKMAGRMM TRRIMGKASF AHIQDMKGRM QIYVTRDSLP 100
QGVYSDFKSW DLGDIVGIEG ELFKTKTEEL SVKVDQIRLL TKALRPMPDK 150
FHGLHDQEQR FRQRYLDLIV NESSRHLFQT RSQVIAQIRR FLDDRGYIEV 200
ETPMMHPLPG GAAARPFETH HNAMNMDLFL RIAPELYLKR LVVGGFEKVY 250
EINRNFRNEG ISTRHNPEFT MLEFYQAYAT YEDMMMLTES MIRHLAEKIF 300
GVMEIKYQGV RIDLNKPFPR LSLRDAILQF NPGITPDQID HLETARELAH 350
KYEIATPAHY GLGKIQTELF EKLVEEKLQQ PIFITHFPKE VSPLSRANEE 400
NDFITDRFEF YVGGREIANG FSELNDPEDQ AARFREQLKA RNAGDLEAMS 450
FDEDYITALE YGLPPTAGEG IGIDRLVMLF TDNASIRDVI LFPLLRSK 498
Length:498
Mass (Da):57,739
Last modified:June 1, 2003 - v1
Checksum:i8092BC68989DAC00
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016828 Genomic DNA. Translation: AAO89981.1.
RefSeqiNP_819467.1. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO89981; AAO89981; CBU_0430.
GeneIDi1208314.
KEGGicbu:CBU_0430.
PATRICi17929547. VBICoxBur82552_0419.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016828 Genomic DNA. Translation: AAO89981.1 .
RefSeqi NP_819467.1. NC_002971.3.

3D structure databases

ProteinModelPortali Q83E97.
SMRi Q83E97. Positions 7-497.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227377.CBU_0430.

Proteomic databases

PRIDEi Q83E97.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO89981 ; AAO89981 ; CBU_0430 .
GeneIDi 1208314.
KEGGi cbu:CBU_0430.
PATRICi 17929547. VBICoxBur82552_0419.

Phylogenomic databases

eggNOGi COG1190.
HOGENOMi HOG000236578.
KOi K04567.
OMAi AMHFDAD.
OrthoDBi EOG69PQ2M.

Enzyme and pathway databases

BioCyci CBUR227377:GJ7S-428-MONOMER.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
HAMAPi MF_00252. Lys_tRNA_synth_class2.
InterProi IPR004364. aa-tRNA-synt_II.
IPR018150. aa-tRNA-synt_II-like.
IPR006195. aa-tRNA-synth_II.
IPR002313. Lys-tRNA-ligase_II.
IPR018149. Lys-tRNA-synth_II_C.
IPR012340. NA-bd_OB-fold.
IPR004365. NA-bd_OB_tRNA.
[Graphical view ]
PANTHERi PTHR22594. PTHR22594. 1 hit.
Pfami PF00152. tRNA-synt_2. 1 hit.
PF01336. tRNA_anti-codon. 1 hit.
[Graphical view ]
PRINTSi PR00982. TRNASYNTHLYS.
SUPFAMi SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00499. lysS_bact. 1 hit.
PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiSYK_COXBU
AccessioniPrimary (citable) accession number: Q83E97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: June 11, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi