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Q83E97

- SYK_COXBU

UniProt

Q83E97 - SYK_COXBU

Protein

Lysine--tRNA ligase

Gene

lysS

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).UniRule annotation

    Cofactori

    Binds 3 magnesium ions per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi409 – 4091Magnesium 1UniRule annotation
    Metal bindingi416 – 4161Magnesium 1UniRule annotation
    Metal bindingi416 – 4161Magnesium 2UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. lysine-tRNA ligase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP
    4. nucleic acid binding Source: InterPro

    GO - Biological processi

    1. lysyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCBUR227377:GJ7S-428-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysine--tRNA ligaseUniRule annotation (EC:6.1.1.6UniRule annotation)
    Alternative name(s):
    Lysyl-tRNA synthetaseUniRule annotation
    Short name:
    LysRSUniRule annotation
    Gene namesi
    Name:lysSUniRule annotation
    Ordered Locus Names:CBU_0430
    OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
    Taxonomic identifieri227377 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
    ProteomesiUP000002671: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 498498Lysine--tRNA ligasePRO_0000152620Add
    BLAST

    Proteomic databases

    PRIDEiQ83E97.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi227377.CBU_0430.

    Structurei

    3D structure databases

    ProteinModelPortaliQ83E97.
    SMRiQ83E97. Positions 7-497.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1190.
    HOGENOMiHOG000236578.
    KOiK04567.
    OMAiAMHFDAD.
    OrthoDBiEOG69PQ2M.

    Family and domain databases

    Gene3Di2.40.50.140. 1 hit.
    HAMAPiMF_00252. Lys_tRNA_synth_class2.
    InterProiIPR004364. aa-tRNA-synt_II.
    IPR018150. aa-tRNA-synt_II-like.
    IPR006195. aa-tRNA-synth_II.
    IPR002313. Lys-tRNA-ligase_II.
    IPR018149. Lys-tRNA-synth_II_C.
    IPR012340. NA-bd_OB-fold.
    IPR004365. NA-bd_OB_tRNA.
    [Graphical view]
    PANTHERiPTHR22594. PTHR22594. 1 hit.
    PfamiPF00152. tRNA-synt_2. 1 hit.
    PF01336. tRNA_anti-codon. 1 hit.
    [Graphical view]
    PRINTSiPR00982. TRNASYNTHLYS.
    SUPFAMiSSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00499. lysS_bact. 1 hit.
    PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q83E97-1 [UniParc]FASTAAdd to Basket

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    MELKDQIKEE NEQIAQRKLK LKKRREEGQA YPNDFKRDSL AADLHAVYDQ    50
    FDSGALTAKA IRVKMAGRMM TRRIMGKASF AHIQDMKGRM QIYVTRDSLP 100
    QGVYSDFKSW DLGDIVGIEG ELFKTKTEEL SVKVDQIRLL TKALRPMPDK 150
    FHGLHDQEQR FRQRYLDLIV NESSRHLFQT RSQVIAQIRR FLDDRGYIEV 200
    ETPMMHPLPG GAAARPFETH HNAMNMDLFL RIAPELYLKR LVVGGFEKVY 250
    EINRNFRNEG ISTRHNPEFT MLEFYQAYAT YEDMMMLTES MIRHLAEKIF 300
    GVMEIKYQGV RIDLNKPFPR LSLRDAILQF NPGITPDQID HLETARELAH 350
    KYEIATPAHY GLGKIQTELF EKLVEEKLQQ PIFITHFPKE VSPLSRANEE 400
    NDFITDRFEF YVGGREIANG FSELNDPEDQ AARFREQLKA RNAGDLEAMS 450
    FDEDYITALE YGLPPTAGEG IGIDRLVMLF TDNASIRDVI LFPLLRSK 498
    Length:498
    Mass (Da):57,739
    Last modified:June 1, 2003 - v1
    Checksum:i8092BC68989DAC00
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO89981.1.
    RefSeqiNP_819467.1. NC_002971.3.

    Genome annotation databases

    EnsemblBacteriaiAAO89981; AAO89981; CBU_0430.
    GeneIDi1208314.
    KEGGicbu:CBU_0430.
    PATRICi17929547. VBICoxBur82552_0419.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO89981.1 .
    RefSeqi NP_819467.1. NC_002971.3.

    3D structure databases

    ProteinModelPortali Q83E97.
    SMRi Q83E97. Positions 7-497.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 227377.CBU_0430.

    Proteomic databases

    PRIDEi Q83E97.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO89981 ; AAO89981 ; CBU_0430 .
    GeneIDi 1208314.
    KEGGi cbu:CBU_0430.
    PATRICi 17929547. VBICoxBur82552_0419.

    Phylogenomic databases

    eggNOGi COG1190.
    HOGENOMi HOG000236578.
    KOi K04567.
    OMAi AMHFDAD.
    OrthoDBi EOG69PQ2M.

    Enzyme and pathway databases

    BioCyci CBUR227377:GJ7S-428-MONOMER.

    Family and domain databases

    Gene3Di 2.40.50.140. 1 hit.
    HAMAPi MF_00252. Lys_tRNA_synth_class2.
    InterProi IPR004364. aa-tRNA-synt_II.
    IPR018150. aa-tRNA-synt_II-like.
    IPR006195. aa-tRNA-synth_II.
    IPR002313. Lys-tRNA-ligase_II.
    IPR018149. Lys-tRNA-synth_II_C.
    IPR012340. NA-bd_OB-fold.
    IPR004365. NA-bd_OB_tRNA.
    [Graphical view ]
    PANTHERi PTHR22594. PTHR22594. 1 hit.
    Pfami PF00152. tRNA-synt_2. 1 hit.
    PF01336. tRNA_anti-codon. 1 hit.
    [Graphical view ]
    PRINTSi PR00982. TRNASYNTHLYS.
    SUPFAMi SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00499. lysS_bact. 1 hit.
    PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RSA 493 / Nine Mile phase I.

    Entry informationi

    Entry nameiSYK_COXBU
    AccessioniPrimary (citable) accession number: Q83E97
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. Coxiella burnetii
      Coxiella burnetii (strain RSA 493): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3