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Q83E97

- SYK_COXBU

UniProt

Q83E97 - SYK_COXBU

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Protein

Lysine--tRNA ligase

Gene

lysS

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).UniRule annotation

Cofactori

Binds 3 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi409 – 4091Magnesium 1UniRule annotation
Metal bindingi416 – 4161Magnesium 1UniRule annotation
Metal bindingi416 – 4161Magnesium 2UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. lysine-tRNA ligase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. nucleic acid binding Source: InterPro

GO - Biological processi

  1. lysyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-428-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine--tRNA ligaseUniRule annotation (EC:6.1.1.6UniRule annotation)
Alternative name(s):
Lysyl-tRNA synthetaseUniRule annotation
Short name:
LysRSUniRule annotation
Gene namesi
Name:lysSUniRule annotation
Ordered Locus Names:CBU_0430
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 498498Lysine--tRNA ligasePRO_0000152620Add
BLAST

Proteomic databases

PRIDEiQ83E97.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi227377.CBU_0430.

Structurei

3D structure databases

ProteinModelPortaliQ83E97.
SMRiQ83E97. Positions 7-497.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1190.
HOGENOMiHOG000236578.
KOiK04567.
OMAiAMHFDAD.
OrthoDBiEOG69PQ2M.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00252. Lys_tRNA_synth_class2.
InterProiIPR004364. aa-tRNA-synt_II.
IPR018150. aa-tRNA-synt_II-like.
IPR006195. aa-tRNA-synth_II.
IPR002313. Lys-tRNA-ligase_II.
IPR018149. Lys-tRNA-synth_II_C.
IPR012340. NA-bd_OB-fold.
IPR004365. NA-bd_OB_tRNA.
[Graphical view]
PANTHERiPTHR22594. PTHR22594. 1 hit.
PfamiPF00152. tRNA-synt_2. 1 hit.
PF01336. tRNA_anti-codon. 1 hit.
[Graphical view]
PRINTSiPR00982. TRNASYNTHLYS.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00499. lysS_bact. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q83E97-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELKDQIKEE NEQIAQRKLK LKKRREEGQA YPNDFKRDSL AADLHAVYDQ
60 70 80 90 100
FDSGALTAKA IRVKMAGRMM TRRIMGKASF AHIQDMKGRM QIYVTRDSLP
110 120 130 140 150
QGVYSDFKSW DLGDIVGIEG ELFKTKTEEL SVKVDQIRLL TKALRPMPDK
160 170 180 190 200
FHGLHDQEQR FRQRYLDLIV NESSRHLFQT RSQVIAQIRR FLDDRGYIEV
210 220 230 240 250
ETPMMHPLPG GAAARPFETH HNAMNMDLFL RIAPELYLKR LVVGGFEKVY
260 270 280 290 300
EINRNFRNEG ISTRHNPEFT MLEFYQAYAT YEDMMMLTES MIRHLAEKIF
310 320 330 340 350
GVMEIKYQGV RIDLNKPFPR LSLRDAILQF NPGITPDQID HLETARELAH
360 370 380 390 400
KYEIATPAHY GLGKIQTELF EKLVEEKLQQ PIFITHFPKE VSPLSRANEE
410 420 430 440 450
NDFITDRFEF YVGGREIANG FSELNDPEDQ AARFREQLKA RNAGDLEAMS
460 470 480 490
FDEDYITALE YGLPPTAGEG IGIDRLVMLF TDNASIRDVI LFPLLRSK
Length:498
Mass (Da):57,739
Last modified:June 1, 2003 - v1
Checksum:i8092BC68989DAC00
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016828 Genomic DNA. Translation: AAO89981.1.
RefSeqiNP_819467.1. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO89981; AAO89981; CBU_0430.
GeneIDi1208314.
KEGGicbu:CBU_0430.
PATRICi17929547. VBICoxBur82552_0419.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016828 Genomic DNA. Translation: AAO89981.1 .
RefSeqi NP_819467.1. NC_002971.3.

3D structure databases

ProteinModelPortali Q83E97.
SMRi Q83E97. Positions 7-497.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227377.CBU_0430.

Proteomic databases

PRIDEi Q83E97.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO89981 ; AAO89981 ; CBU_0430 .
GeneIDi 1208314.
KEGGi cbu:CBU_0430.
PATRICi 17929547. VBICoxBur82552_0419.

Phylogenomic databases

eggNOGi COG1190.
HOGENOMi HOG000236578.
KOi K04567.
OMAi AMHFDAD.
OrthoDBi EOG69PQ2M.

Enzyme and pathway databases

BioCyci CBUR227377:GJ7S-428-MONOMER.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
HAMAPi MF_00252. Lys_tRNA_synth_class2.
InterProi IPR004364. aa-tRNA-synt_II.
IPR018150. aa-tRNA-synt_II-like.
IPR006195. aa-tRNA-synth_II.
IPR002313. Lys-tRNA-ligase_II.
IPR018149. Lys-tRNA-synth_II_C.
IPR012340. NA-bd_OB-fold.
IPR004365. NA-bd_OB_tRNA.
[Graphical view ]
PANTHERi PTHR22594. PTHR22594. 1 hit.
Pfami PF00152. tRNA-synt_2. 1 hit.
PF01336. tRNA_anti-codon. 1 hit.
[Graphical view ]
PRINTSi PR00982. TRNASYNTHLYS.
SUPFAMi SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00499. lysS_bact. 1 hit.
PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiSYK_COXBU
AccessioniPrimary (citable) accession number: Q83E97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3