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Q83DY1

- SYL_COXBU

UniProt

Q83DY1 - SYL_COXBU

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei579 – 5791ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-562-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:CBU_0559
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 820820Leucine--tRNA ligasePRO_0000152008Add
BLAST

Proteomic databases

PRIDEiQ83DY1.

Interactioni

Protein-protein interaction databases

STRINGi227377.CBU_0559.

Structurei

3D structure databases

ProteinModelPortaliQ83DY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi576 – 5805"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q83DY1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNESYQPTLI EQLAQEYWEE NETFEVKEDL SREKFYCLSM LPYPSGDLHM
60 70 80 90 100
GHVRNYTIGD VIARYQIHKG RNVLQPMGWD AFGLPAENAA IQRELPPAEW
110 120 130 140 150
TRKNIKKMRK QLKQLGFAYD WSREITTCDS TYYRWEQWLF LQLYKKGLAY
160 170 180 190 200
KKNAIVNWDP VDQTVLANEQ IVDGRGWRSG AVVERREISQ WFLKITDYSE
210 220 230 240 250
ELLKDLDELK EWPEQVITMQ RNWIGQSQGV IINFNLEKGP DKLQVYTTRP
260 270 280 290 300
DTLMGVTYLA IAPEHPLAKE RAKKSKKIAA FLKKCKQTRV AEADIATQEK
310 320 330 340 350
EGIDSGLFAV HPLSKEKLPI WIANFVLMEY ASGVVMAVPA HDERDHEFAL
360 370 380 390 400
KYDLPLKPVI EPADGHDWDY NQAAYTNPGK LINSGSFNDI DSKTAFNVIA
410 420 430 440 450
DYLKNNGAGS RQTHYRLRDW GISRQRYWGT PIPIIYCKTC GTVPVPENQL
460 470 480 490 500
PVLLPEDIIP TGHGSPLKET ASFYKTRCPV CNKPATRETD TMDTFVESSW
510 520 530 540 550
YYARYSCPDQ DKVMLDDRAK YWTPVDQYIG GIEHAVMHLL YARFMHKILR
560 570 580 590 600
DLGLLNSNEP FIRLLTQGMV LKDGAKMSKS KGNVVTPQSL IKKYGADTVR
610 620 630 640 650
LFIIFAAPPE QDLEWSDSGV EGAYRFLKKL WGFSYRIKDA LLAINQQKER
660 670 680 690 700
SNYQWEAPEH RQTRQQIHEC LQQANIDMER LQFNTVVSAV MKILNILIKL
710 720 730 740 750
TTDNDAEAHL IREGTGILLR LLSPITPHIS HHLWQSLGFG GDILDTPWPR
760 770 780 790 800
PDPKALQTTE LELIVQINGK LRGRIQVPTE ASKEIIESTA LNQENVQRHL
810 820
ADKKIKKVIV VPKKLINIVV
Length:820
Mass (Da):94,259
Last modified:June 1, 2003 - v1
Checksum:i1D1D23FF03279EE6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO90104.1.
RefSeqiNP_819590.1. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO90104; AAO90104; CBU_0559.
GeneIDi1208444.
KEGGicbu:CBU_0559.
PATRICi17929819. VBICoxBur82552_0554.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO90104.1 .
RefSeqi NP_819590.1. NC_002971.3.

3D structure databases

ProteinModelPortali Q83DY1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227377.CBU_0559.

Proteomic databases

PRIDEi Q83DY1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO90104 ; AAO90104 ; CBU_0559 .
GeneIDi 1208444.
KEGGi cbu:CBU_0559.
PATRICi 17929819. VBICoxBur82552_0554.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CBUR227377:GJ7S-562-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiSYL_COXBU
AccessioniPrimary (citable) accession number: Q83DY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 1, 2003
Last modified: November 26, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3