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Q83DN1 (DAPD_COXBU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

EC=2.3.1.117
Alternative name(s):
Tetrahydrodipicolinate N-succinyltransferase
Short name=THDP succinyltransferase
Short name=THP succinyltransferase
Short name=Tetrahydropicolinate succinylase
Gene names
Name:dapD
Ordered Locus Names:CBU_0667
OrganismCoxiella burnetii (strain RSA 493 / Nine Mile phase I) [Reference proteome] [HAMAP]
Taxonomic identifier227377 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella

Protein attributes

Sequence length271 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate. HAMAP-Rule MF_00811

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3. HAMAP-Rule MF_00811

Subunit structure

Homotrimer By similarity. HAMAP-Rule MF_00811

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00811.

Sequence similarities

Belongs to the transferase hexapeptide repeat family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2712712,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase HAMAP-Rule MF_00811
PRO_0000196932

Sites

Binding site1021Substrate By similarity
Binding site1391Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q83DN1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 1234EDBE30DBADB9

FASTA27129,848
        10         20         30         40         50         60 
MTDLKTIIEE AYQNKDNFTT DTVPKKIHQA IHQTIELLDN GELRIAEKQN GQWNTNEWAK 

        70         80         90        100        110        120 
MAILLYFKTE PLKTFDAGYT FFYDKIPLKY TNNTSQPQSG VRVVPHAIVR KGAYLAPNTV 

       130        140        150        160        170        180 
LMPSYINIGA YVDSGTLIDT WATVGSCAQI GKNVHLSGGA GIGGVLEPLQ AHPTIIEDDC 

       190        200        210        220        230        240 
FIGARSEIVE GVMVEKGSVI SMGVFVGQST PIYNRQTQEI TYGRIPAGSV VIPGSLPSKD 

       250        260        270 
GHYNRYSAII VKQVDKKTRS KVSLNELLRE G 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016828 Genomic DNA. Translation: AAO90211.1.
RefSeqNP_819697.1. NC_002971.3.

3D structure databases

ProteinModelPortalQ83DN1.
SMRQ83DN1. Positions 1-269.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING227377.CBU_0667.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO90211; AAO90211; CBU_0667.
GeneID1208553.
KEGGcbu:CBU_0667.
PATRIC17930013. VBICoxBur82552_0650.

Phylogenomic databases

eggNOGCOG2171.
HOGENOMHOG000003295.
KOK00674.
OMAWVTVGSC.
OrthoDBEOG68H8BV.
ProtClustDBPRK11830.

Enzyme and pathway databases

BioCycCBUR227377:GJ7S-662-MONOMER.
UniPathwayUPA00034; UER00019.

Family and domain databases

Gene3D1.10.166.10. 1 hit.
HAMAPMF_00811. DapD.
InterProIPR005664. DapD_Trfase_Hexpep_rpt_fam.
IPR001451. Hexapep_transf.
IPR023180. THP_succinylTrfase_dom1.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PANTHERPTHR19136:SF52. PTHR19136:SF52. 1 hit.
PfamPF00132. Hexapep. 1 hit.
[Graphical view]
SUPFAMSSF51161. SSF51161. 1 hit.
TIGRFAMsTIGR00965. dapD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDAPD_COXBU
AccessionPrimary (citable) accession number: Q83DN1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 1, 2003
Last modified: February 19, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Coxiella burnetii

Coxiella burnetii (strain RSA 493): entries and gene names