Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q83DJ3 (TIG_COXBU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Trigger factor

Short name=TF
EC=5.2.1.8
Alternative name(s):
PPIase
Gene names
Name:tig
Ordered Locus Names:CBU_0737
OrganismCoxiella burnetii (strain RSA 493 / Nine Mile phase I) [Reference proteome] [HAMAP]
Taxonomic identifier227377 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella

Protein attributes

Sequence length442 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase By similarity. HAMAP-Rule MF_00303

Catalytic activity

Peptidylproline (omega=180) = peptidylproline (omega=0). HAMAP-Rule MF_00303

Subcellular location

Cytoplasm. Note: About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm By similarity. HAMAP-Rule MF_00303

Developmental stage

More than twofold more abundant in the large cell variant (LCV) stage than in the small cell variant (SCV) stage (at protein level). LCVs are more metabolically active than SCVs. Ref.2

Domain

Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own By similarity. HAMAP-Rule MF_00303

Sequence similarities

Belongs to the FKBP-type PPIase family. Tig subfamily.

Contains 1 PPIase FKBP-type domain.

Ontologies

Keywords
   Biological processCell cycle
Cell division
   Cellular componentCytoplasm
   Molecular functionChaperone
Isomerase
Rotamase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell cycle

Inferred from electronic annotation. Source: UniProtKB-KW

cell division

Inferred from electronic annotation. Source: UniProtKB-KW

protein folding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

protein transport

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionpeptidyl-prolyl cis-trans isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 442442Trigger factor HAMAP-Rule MF_00303
PRO_0000179343

Regions

Domain165 – 25086PPIase FKBP-type

Sequences

Sequence LengthMass (Da)Tools
Q83DJ3 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 680559D84F93BE00

FASTA44250,247
        10         20         30         40         50         60 
MRGNFMSSIE KLGGLKQRLT ITVPAEEVDK AYKSRLLKVA RTAKIPKFRP GKASPAVVEK 

        70         80         90        100        110        120 
LYGKAILQEV GSELIQSSLR EAVEEHQLRV AGAPDIKMDK ILRGEPFKYV VNFEVYPEIT 

       130        140        150        160        170        180 
LESLAGETIE RTQVEITEED LDKMLEALRK QYAEWKEMDR PAKADDRVII DFEGTLDGKP 

       190        200        210        220        230        240 
FERGSAKDFQ LELGSKRMIA GFEEGIEGMK PGESKALDIT FPADYPSEDL AGKAAVFNIT 

       250        260        270        280        290        300 
LQKVMAPELP VLDEQFAERL GIKEGGLEAL RQKVRTNMEK EVHHHMENKL KMAVLDKLIE 

       310        320        330        340        350        360 
RNPIEVPESL IEAEIDHLQQ MTRQQVAMQT HKPDEAKKME LPRDPYREQA TKRVKLGLLL 

       370        380        390        400        410        420 
AEVVKQHKIK ADPEQLRARV EEVAASYQDP EKVISWYYTN KQMLSEIESV VLEDQAVAQL 

       430        440 
MSELEVKDQA IPYEEAVKQI QQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016828 Genomic DNA. Translation: AAO90277.1.
RefSeqNP_819763.1. NC_002971.3.

3D structure databases

ProteinModelPortalQ83DJ3.
SMRQ83DJ3. Positions 150-252.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING227377.CBU_0737.

Proteomic databases

PRIDEQ83DJ3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO90277; AAO90277; CBU_0737.
GeneID1208628.
KEGGcbu:CBU_0737.
PATRIC17930165. VBICoxBur82552_0721.

Phylogenomic databases

eggNOGCOG0544.
HOGENOMHOG000218239.
KOK03545.
OMAMQVSVEN.
OrthoDBEOG63VBX3.
ProtClustDBPRK01490.

Enzyme and pathway databases

BioCycCBUR227377:GJ7S-734-MONOMER.

Family and domain databases

Gene3D1.10.3120.10. 1 hit.
3.30.70.1050. 1 hit.
HAMAPMF_00303. Trigger_factor_Tig.
InterProIPR001179. PPIase_FKBP_dom.
IPR005215. Trig_fac.
IPR008880. Trigger_fac_C.
IPR008881. Trigger_fac_ribosome-bd_bac.
IPR027304. Trigger_fact/SurA_dom.
[Graphical view]
PfamPF00254. FKBP_C. 1 hit.
PF05698. Trigger_C. 1 hit.
PF05697. Trigger_N. 1 hit.
[Graphical view]
PIRSFPIRSF003095. Trigger_factor. 1 hit.
SUPFAMSSF102735. SSF102735. 1 hit.
SSF109998. SSF109998. 1 hit.
TIGRFAMsTIGR00115. tig. 1 hit.
PROSITEPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTIG_COXBU
AccessionPrimary (citable) accession number: Q83DJ3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Coxiella burnetii

Coxiella burnetii (strain RSA 493): entries and gene names