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Q83DJ3

- TIG_COXBU

UniProt

Q83DJ3 - TIG_COXBU

Protein

Trigger factor

Gene

tig

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.UniRule annotation

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).UniRule annotation

    GO - Molecular functioni

    1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. protein folding Source: UniProtKB-HAMAP
    4. protein transport Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Chaperone, Isomerase, Rotamase

    Keywords - Biological processi

    Cell cycle, Cell division

    Enzyme and pathway databases

    BioCyciCBUR227377:GJ7S-734-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trigger factorUniRule annotation (EC:5.2.1.8UniRule annotation)
    Short name:
    TFUniRule annotation
    Alternative name(s):
    PPIaseUniRule annotation
    Gene namesi
    Name:tigUniRule annotation
    Ordered Locus Names:CBU_0737
    OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
    Taxonomic identifieri227377 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
    ProteomesiUP000002671: Chromosome

    Subcellular locationi

    Cytoplasm
    Note: About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 442442Trigger factorPRO_0000179343Add
    BLAST

    Proteomic databases

    PRIDEiQ83DJ3.

    Expressioni

    Developmental stagei

    More than twofold more abundant in the large cell variant (LCV) stage than in the small cell variant (SCV) stage (at protein level). LCVs are more metabolically active than SCVs.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi227377.CBU_0737.

    Structurei

    3D structure databases

    ProteinModelPortaliQ83DJ3.
    SMRiQ83DJ3. Positions 150-252.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini165 – 25086PPIase FKBP-typeUniRule annotationAdd
    BLAST

    Domaini

    Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.UniRule annotation

    Sequence similaritiesi

    Belongs to the FKBP-type PPIase family. Tig subfamily.UniRule annotation
    Contains 1 PPIase FKBP-type domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0544.
    HOGENOMiHOG000218239.
    KOiK03545.
    OMAiMQVSVEN.
    OrthoDBiEOG63VBX3.

    Family and domain databases

    Gene3Di1.10.3120.10. 1 hit.
    3.30.70.1050. 1 hit.
    HAMAPiMF_00303. Trigger_factor_Tig.
    InterProiIPR001179. PPIase_FKBP_dom.
    IPR005215. Trig_fac.
    IPR008880. Trigger_fac_C.
    IPR008881. Trigger_fac_ribosome-bd_bac.
    IPR027304. Trigger_fact/SurA_dom.
    [Graphical view]
    PfamiPF00254. FKBP_C. 1 hit.
    PF05698. Trigger_C. 1 hit.
    PF05697. Trigger_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003095. Trigger_factor. 1 hit.
    SUPFAMiSSF102735. SSF102735. 1 hit.
    SSF109998. SSF109998. 1 hit.
    TIGRFAMsiTIGR00115. tig. 1 hit.
    PROSITEiPS50059. FKBP_PPIASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q83DJ3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRGNFMSSIE KLGGLKQRLT ITVPAEEVDK AYKSRLLKVA RTAKIPKFRP    50
    GKASPAVVEK LYGKAILQEV GSELIQSSLR EAVEEHQLRV AGAPDIKMDK 100
    ILRGEPFKYV VNFEVYPEIT LESLAGETIE RTQVEITEED LDKMLEALRK 150
    QYAEWKEMDR PAKADDRVII DFEGTLDGKP FERGSAKDFQ LELGSKRMIA 200
    GFEEGIEGMK PGESKALDIT FPADYPSEDL AGKAAVFNIT LQKVMAPELP 250
    VLDEQFAERL GIKEGGLEAL RQKVRTNMEK EVHHHMENKL KMAVLDKLIE 300
    RNPIEVPESL IEAEIDHLQQ MTRQQVAMQT HKPDEAKKME LPRDPYREQA 350
    TKRVKLGLLL AEVVKQHKIK ADPEQLRARV EEVAASYQDP EKVISWYYTN 400
    KQMLSEIESV VLEDQAVAQL MSELEVKDQA IPYEEAVKQI QQ 442
    Length:442
    Mass (Da):50,247
    Last modified:June 1, 2003 - v1
    Checksum:i680559D84F93BE00
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO90277.1.
    RefSeqiNP_819763.1. NC_002971.3.
    WP_010957768.1. NC_002971.3.

    Genome annotation databases

    EnsemblBacteriaiAAO90277; AAO90277; CBU_0737.
    GeneIDi1208628.
    KEGGicbu:CBU_0737.
    PATRICi17930165. VBICoxBur82552_0721.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO90277.1 .
    RefSeqi NP_819763.1. NC_002971.3.
    WP_010957768.1. NC_002971.3.

    3D structure databases

    ProteinModelPortali Q83DJ3.
    SMRi Q83DJ3. Positions 150-252.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 227377.CBU_0737.

    Proteomic databases

    PRIDEi Q83DJ3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO90277 ; AAO90277 ; CBU_0737 .
    GeneIDi 1208628.
    KEGGi cbu:CBU_0737.
    PATRICi 17930165. VBICoxBur82552_0721.

    Phylogenomic databases

    eggNOGi COG0544.
    HOGENOMi HOG000218239.
    KOi K03545.
    OMAi MQVSVEN.
    OrthoDBi EOG63VBX3.

    Enzyme and pathway databases

    BioCyci CBUR227377:GJ7S-734-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3120.10. 1 hit.
    3.30.70.1050. 1 hit.
    HAMAPi MF_00303. Trigger_factor_Tig.
    InterProi IPR001179. PPIase_FKBP_dom.
    IPR005215. Trig_fac.
    IPR008880. Trigger_fac_C.
    IPR008881. Trigger_fac_ribosome-bd_bac.
    IPR027304. Trigger_fact/SurA_dom.
    [Graphical view ]
    Pfami PF00254. FKBP_C. 1 hit.
    PF05698. Trigger_C. 1 hit.
    PF05697. Trigger_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003095. Trigger_factor. 1 hit.
    SUPFAMi SSF102735. SSF102735. 1 hit.
    SSF109998. SSF109998. 1 hit.
    TIGRFAMsi TIGR00115. tig. 1 hit.
    PROSITEi PS50059. FKBP_PPIASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RSA 493 / Nine Mile phase I.
    2. "Proteome and antigen profiling of Coxiella burnetii developmental forms."
      Coleman S.A., Fischer E.R., Cockrell D.C., Voth D.E., Howe D., Mead D.J., Samuel J.E., Heinzen R.A.
      Infect. Immun. 75:290-298(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, DEVELOPMENTAL STAGE.
      Strain: Nine Mile Crazy / RSA 514.

    Entry informationi

    Entry nameiTIG_COXBU
    AccessioniPrimary (citable) accession number: Q83DJ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 16, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Coxiella burnetii
      Coxiella burnetii (strain RSA 493): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3