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Q83DJ3

- TIG_COXBU

UniProt

Q83DJ3 - TIG_COXBU

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Protein
Trigger factor
Gene
tig, CBU_0737
Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase By similarity.UniRule annotation

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).UniRule annotation

GO - Molecular functioni

  1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. protein folding Source: UniProtKB-HAMAP
  4. protein transport Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Chaperone, Isomerase, Rotamase

Keywords - Biological processi

Cell cycle, Cell division

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-734-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Trigger factor (EC:5.2.1.8)
Short name:
TF
Alternative name(s):
PPIase
Gene namesi
Name:tig
Ordered Locus Names:CBU_0737
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671: Chromosome

Subcellular locationi

Cytoplasm
Note: About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm By similarity.UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 442442Trigger factorUniRule annotation
PRO_0000179343Add
BLAST

Proteomic databases

PRIDEiQ83DJ3.

Expressioni

Developmental stagei

More than twofold more abundant in the large cell variant (LCV) stage than in the small cell variant (SCV) stage (at protein level). LCVs are more metabolically active than SCVs.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi227377.CBU_0737.

Structurei

3D structure databases

ProteinModelPortaliQ83DJ3.
SMRiQ83DJ3. Positions 150-252.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini165 – 25086PPIase FKBP-type
Add
BLAST

Domaini

Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own By similarity.UniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0544.
HOGENOMiHOG000218239.
KOiK03545.
OMAiMQVSVEN.
OrthoDBiEOG63VBX3.

Family and domain databases

Gene3Di1.10.3120.10. 1 hit.
3.30.70.1050. 1 hit.
HAMAPiMF_00303. Trigger_factor_Tig.
InterProiIPR001179. PPIase_FKBP_dom.
IPR005215. Trig_fac.
IPR008880. Trigger_fac_C.
IPR008881. Trigger_fac_ribosome-bd_bac.
IPR027304. Trigger_fact/SurA_dom.
[Graphical view]
PfamiPF00254. FKBP_C. 1 hit.
PF05698. Trigger_C. 1 hit.
PF05697. Trigger_N. 1 hit.
[Graphical view]
PIRSFiPIRSF003095. Trigger_factor. 1 hit.
SUPFAMiSSF102735. SSF102735. 1 hit.
SSF109998. SSF109998. 1 hit.
TIGRFAMsiTIGR00115. tig. 1 hit.
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q83DJ3-1 [UniParc]FASTAAdd to Basket

« Hide

MRGNFMSSIE KLGGLKQRLT ITVPAEEVDK AYKSRLLKVA RTAKIPKFRP    50
GKASPAVVEK LYGKAILQEV GSELIQSSLR EAVEEHQLRV AGAPDIKMDK 100
ILRGEPFKYV VNFEVYPEIT LESLAGETIE RTQVEITEED LDKMLEALRK 150
QYAEWKEMDR PAKADDRVII DFEGTLDGKP FERGSAKDFQ LELGSKRMIA 200
GFEEGIEGMK PGESKALDIT FPADYPSEDL AGKAAVFNIT LQKVMAPELP 250
VLDEQFAERL GIKEGGLEAL RQKVRTNMEK EVHHHMENKL KMAVLDKLIE 300
RNPIEVPESL IEAEIDHLQQ MTRQQVAMQT HKPDEAKKME LPRDPYREQA 350
TKRVKLGLLL AEVVKQHKIK ADPEQLRARV EEVAASYQDP EKVISWYYTN 400
KQMLSEIESV VLEDQAVAQL MSELEVKDQA IPYEEAVKQI QQ 442
Length:442
Mass (Da):50,247
Last modified:June 1, 2003 - v1
Checksum:i680559D84F93BE00
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016828 Genomic DNA. Translation: AAO90277.1.
RefSeqiNP_819763.1. NC_002971.3.
WP_010957768.1. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO90277; AAO90277; CBU_0737.
GeneIDi1208628.
KEGGicbu:CBU_0737.
PATRICi17930165. VBICoxBur82552_0721.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016828 Genomic DNA. Translation: AAO90277.1 .
RefSeqi NP_819763.1. NC_002971.3.
WP_010957768.1. NC_002971.3.

3D structure databases

ProteinModelPortali Q83DJ3.
SMRi Q83DJ3. Positions 150-252.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227377.CBU_0737.

Proteomic databases

PRIDEi Q83DJ3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO90277 ; AAO90277 ; CBU_0737 .
GeneIDi 1208628.
KEGGi cbu:CBU_0737.
PATRICi 17930165. VBICoxBur82552_0721.

Phylogenomic databases

eggNOGi COG0544.
HOGENOMi HOG000218239.
KOi K03545.
OMAi MQVSVEN.
OrthoDBi EOG63VBX3.

Enzyme and pathway databases

BioCyci CBUR227377:GJ7S-734-MONOMER.

Family and domain databases

Gene3Di 1.10.3120.10. 1 hit.
3.30.70.1050. 1 hit.
HAMAPi MF_00303. Trigger_factor_Tig.
InterProi IPR001179. PPIase_FKBP_dom.
IPR005215. Trig_fac.
IPR008880. Trigger_fac_C.
IPR008881. Trigger_fac_ribosome-bd_bac.
IPR027304. Trigger_fact/SurA_dom.
[Graphical view ]
Pfami PF00254. FKBP_C. 1 hit.
PF05698. Trigger_C. 1 hit.
PF05697. Trigger_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF003095. Trigger_factor. 1 hit.
SUPFAMi SSF102735. SSF102735. 1 hit.
SSF109998. SSF109998. 1 hit.
TIGRFAMsi TIGR00115. tig. 1 hit.
PROSITEi PS50059. FKBP_PPIASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.
  2. "Proteome and antigen profiling of Coxiella burnetii developmental forms."
    Coleman S.A., Fischer E.R., Cockrell D.C., Voth D.E., Howe D., Mead D.J., Samuel J.E., Heinzen R.A.
    Infect. Immun. 75:290-298(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, DEVELOPMENTAL STAGE.
    Strain: Nine Mile Crazy / RSA 514.

Entry informationi

Entry nameiTIG_COXBU
AccessioniPrimary (citable) accession number: Q83DJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi