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Protein

FAD assembly factor SdhE

Gene

sdhE

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH and other flavinylated proteins as well.By similarity

GO - Biological processi

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
FAD assembly factor SdhE
Gene namesi
Name:sdhE
Ordered Locus Names:CBU_0870
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
Proteomesi
  • UP000002671 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm By similarity

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002143931 – 82FAD assembly factor SdhEAdd BLAST82

Proteomic databases

PRIDEiQ83D70.

Interactioni

Protein-protein interaction databases

STRINGi227377.CBU_0870.

Structurei

3D structure databases

ProteinModelPortaliQ83D70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SdhE FAD assembly factor family.Curated

Phylogenomic databases

eggNOGiENOG4105Y75. Bacteria.
COG2938. LUCA.
HOGENOMiHOG000160701.
KOiK09159.
OMAiDLFAWFM.

Family and domain databases

Gene3Di1.10.150.250. 1 hit.
InterProiView protein in InterPro
IPR005631. SDH.
PfamiView protein in Pfam
PF03937. Sdh5. 1 hit.
SUPFAMiSSF109910. SSF109910. 1 hit.

Sequencei

Sequence statusi: Complete.

Q83D70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEPLASKKI RWKCRRGMLE LDILLERFYE EKFRSLTKNE KEIFNQLLDQ
60 70 80
PDPLLYDWLL GHVTPESSEF KKIIRKIQQL SS
Length:82
Mass (Da):9,924
Last modified:June 1, 2003 - v1
Checksum:iB7917BA1E3FA8457
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO90403.1.
RefSeqiNP_819889.1. NC_002971.3.
WP_005768810.1. NZ_CDBG01000001.1.

Genome annotation databases

EnsemblBacteriaiAAO90403; AAO90403; CBU_0870.
GeneIDi1208763.
KEGGicbu:CBU_0870.
PATRICi17930437. VBICoxBur82552_0855.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO90403.1.
RefSeqiNP_819889.1. NC_002971.3.
WP_005768810.1. NZ_CDBG01000001.1.

3D structure databases

ProteinModelPortaliQ83D70.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi227377.CBU_0870.

Proteomic databases

PRIDEiQ83D70.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO90403; AAO90403; CBU_0870.
GeneIDi1208763.
KEGGicbu:CBU_0870.
PATRICi17930437. VBICoxBur82552_0855.

Phylogenomic databases

eggNOGiENOG4105Y75. Bacteria.
COG2938. LUCA.
HOGENOMiHOG000160701.
KOiK09159.
OMAiDLFAWFM.

Family and domain databases

Gene3Di1.10.150.250. 1 hit.
InterProiView protein in InterPro
IPR005631. SDH.
PfamiView protein in Pfam
PF03937. Sdh5. 1 hit.
SUPFAMiSSF109910. SSF109910. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSDHE_COXBU
AccessioniPrimary (citable) accession number: Q83D70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: June 1, 2003
Last modified: February 15, 2017
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.