Q83D67 (AROC_COXBU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chorismate synthase
EC=4.2.3.5

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Ordered Locus Names:	CBU_0874

Organism

Coxiella burnetii (strain RSA 493 / Nine Mile phase I) [Reference proteome] [HAMAP]

Taxonomic identifier

227377 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella › Coxiella burnetii

Protein attributes

Sequence length	352 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP-Rule MF_00300
Cofactor	Reduced flavin By similarity.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP-Rule MF_00300
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP chorismate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	chorismate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 352	352	Chorismate synthase HAMAP-Rule MF_00300		PRO_0000140580

Sequences

	Sequence		Length	Mass (Da)
	Q83D67 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 00744BEF3C1AA44B	FASTA	352	37,949
	10 20 30 40 50 60 MSGNSFGKLF TVTTAGESHG PALVAIVDGC PAGLSLTEAD IQPDIDRRKT GKSRFTSQRR 70 80 90 100 110 120 ESDQVKILSG VFEGVTTGTP IALLIENADQ RPRDYSQIKD LFRPGHGDYT YFKKYGFRDY 130 140 150 160 170 180 RGGGRASARE TVMRVAAGAI AKKYLREKVN LTIQGYTAAV GAIRAERIDL SAVEKNPFFF 190 200 210 220 230 240 PDEVQIPHLE QLIMKLRRDG DSIGARLNVI AKGVPCGLGE PVFDKLDADI ASAMMGINAV 250 260 270 280 290 300 KGVEIGDGFA VVEQKGSFHR DELSKKGFLS NHAGGTLAGI SSGQDILVSL AFKPASSIRI 310 320 330 340 350 PGKTLDINGK AVEVVTTGRH DPCVGLRAVP IAEAMLALVL MDHYLRYKAQ RG

References

[1]

"Complete genome sequence of the Q-fever pathogen, Coxiella burnetii." Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A. , Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E., Fraser C.M., Heidelberg J.F. Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RSA 493 / Nine Mile phase I.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016828 Genomic DNA. Translation: AAO90406.1.
RefSeq	NP_819892.1. NC_002971.3.
3D structure databases
ProteinModelPortal	Q83D67.
ModBase	Search...
Protein-protein interaction databases
STRING	227377.CBU_0874.
Proteomic databases
PRIDE	Q83D67.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAO90406; AAO90406; CBU_0874.
GeneID	1208767.
KEGG	cbu:CBU_0874.
PATRIC	17930447. VBICoxBur82552_0860.
Phylogenomic databases
eggNOG	COG0082.
HOGENOM	HOG000060335.
KO	K01736.
OMA	GAVIDGC.
ProtClustDB	PRK05382.
Enzyme and pathway databases
BioCyc	CBUR227377:GJ7S-868-MONOMER.
UniPathway	UPA00053; UER00090.
Family and domain databases
HAMAP	MF_00300. Chorismate_synth.
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
PANTHER	PTHR21085. PTHR21085. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
SUPFAM	SSF103263. Chorismate_synth. 1 hit.
TIGRFAMs	TIGR00033. aroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC_COXBU

Accession

Primary (citable) accession number: Q83D67

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program