Reviewed, UniProtKB/Swiss-Prot Q83CY8 (BCP_COXBU)

Names and origin

Protein names

Recommended name:
    Putative peroxiredoxin bcp
    EC=1.11.1.15
Alternative name(s):
    Thioredoxin reductase
    Bacterioferritin comigratory protein

Gene names

Name:	bcp
Ordered Locus Names:	CBU_0963

Organism

Coxiella burnetii [Complete proteome] [HAMAP]

Taxonomic identifier

777 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella

Protein attributes

Sequence length	151 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH.
Developmental stage	More than twofold more abundant in the large cell variant (LCV) stage than in the small cell variant (SCV) stage (at protein level). LCVs are more metabolically active than SCVs.
Sequence similarities	Belongs to the ahpC/TSA family. Contains 1 thioredoxin domain.

Ontologies

Keywords
Domain	Redox-active center
Molecular function	Oxidoreductase Peroxidase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	peroxiredoxin activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 151	151	Putative peroxiredoxin bcp		PRO_0000320581
Regions
	Domain	3 – 151	149	Thioredoxin
Sites
	Active site	45	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q83CY8-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: F1E03D40A3F4FF56	FASTA	151	16,850
	10 20 30 40 50 60 MSIEVGQKAP IFTLPTDEGE MLSLDDLKGK KVILYFYPKD DTPGCTKEAC GFRDVWSQLS 70 80 90 100 110 120 KAGVVVLGIS KDSVKAHQSF KQKYNLPFTL LSDKDNTVCE QYGVMVDKNR FGKKYKGIER 130 140 150 TTFLIDEEGV ISAVWPKVKV DGHVAEVVGR L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of the Q-fever pathogen, Coxiella burnetii." Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A. , Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E., Fraser C.M., Heidelberg J.F. Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed: 12704232] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nine Mile phase I / RSA 493.
[2]	"Proteome and antigen profiling of Coxiella burnetii developmental forms." Coleman S.A., Fischer E.R., Cockrell D.C., Voth D.E., Howe D., Mead D.J., Samuel J.E., Heinzen R.A. Infect. Immun. 75:290-298(2007) [PubMed: 17088354] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, DEVELOPMENTAL STAGE. Strain: Nine Mile Crazy / RSA 514.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE016828 Genomic DNA. Translation: AAO90485.1.
RefSeq	NP_819971.1.
3D structure databases
HSSP	HSSP built from PDB template 1QMV based on UniProtKB P32119.
ModBase	Search...
Protein family/group databases
PeroxiBase	4369. CbuBCP.
Genome annotation databases
GeneID	1208858.
GenomeReviews	Gene locus CBU_0963 in contig AE016828_GR.
KEGG	cbu:CBU_0963.
NMPDR	fig|227377.1.peg.915.
TIGR	CBU_0963.
Phylogenomic databases
HOGENOM	Q83CY8.
Enzyme and pathway databases
BioCyc	CBUR227377:CBU_0963-MON.
Family and domain databases
InterPro	IPR000866. AhpC-TSA. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF00578. AhpC-TSA. 1 hit. [Graphical view]
PROSITE	PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
BLOCKS	Search...
ProtoNet	Search...

Entry information

Entry name

BCP_COXBU

Accession

Primary (citable) accession number: Q83CY8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	June 1, 2003
Last modified:	November 4, 2008
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)