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Protein

23S rRNA (guanosine-2'-O-)-methyltransferase RlmB

Gene

rlmB

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Specifically methylates the ribose of guanosine 2251 in 23S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanosine(2251) in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylguanosine(2251) in 23S rRNA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei198S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei218S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei227S-adenosyl-L-methionine; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processrRNA processing
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
23S rRNA (guanosine-2'-O-)-methyltransferase RlmBUniRule annotation (EC:2.1.1.185UniRule annotation)
Alternative name(s):
23S rRNA (guanosine2251 2'-O)-methyltransferaseUniRule annotation
23S rRNA Gm2251 2'-O-methyltransferaseUniRule annotation
Gene namesi
Name:rlmBUniRule annotation
Ordered Locus Names:CBU_0986
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
Proteomesi
  • UP000002671 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001597841 – 25023S rRNA (guanosine-2'-O-)-methyltransferase RlmBAdd BLAST250

Interactioni

Protein-protein interaction databases

STRINGi227377.CBU_0986.

Structurei

3D structure databases

ProteinModelPortaliQ83CW6.
SMRiQ83CW6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. RlmB subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C2N. Bacteria.
COG0566. LUCA.
HOGENOMiHOG000218798.
KOiK03218.
OMAiWVEGVHQ.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
3.40.1280.10. 1 hit.
HAMAPiMF_01887. 23SrRNA_methyltr_B. 1 hit.
InterProiView protein in InterPro
IPR024915. 23S_rRNA_MeTrfase_RlmB.
IPR029028. Alpha/beta_knot_MTases.
IPR029064. L30e-like.
IPR004441. rRNA_MeTrfase_TrmH.
IPR001537. SpoU_MeTrfase.
IPR013123. SpoU_subst-bd.
IPR029026. tRNA_m1G_MTases_N.
PANTHERiPTHR12029:SF58. PTHR12029:SF58. 1 hit.
PfamiView protein in Pfam
PF00588. SpoU_methylase. 1 hit.
PF08032. SpoU_sub_bind. 1 hit.
SMARTiView protein in SMART
SM00967. SpoU_sub_bind. 1 hit.
SUPFAMiSSF55315. SSF55315. 1 hit.
SSF75217. SSF75217. 1 hit.
TIGRFAMsiTIGR00186. rRNA_methyl_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q83CW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKIKSIYGI HAVSGVLDAA PQRIVKLYVQ ENRDDQRLQS LVEKAKALGV
60 70 80 90 100
KVILLSRTEL NTLSNEKHQG IVADCEEVEN LDESALLSLL KKRETPALLL
110 120 130 140 150
ILDGVKDPHN LGACLRSANA FGVRAVIAPK DRAVGVTPVV RKVACGAAEM
160 170 180 190 200
TPFIRVTNLS RTIDWLQKEG VWIVGTAVEA ETLIQEIDLT GDIAIVLGSE
210 220 230 240 250
GAGLRRLTKE RCDFLAQIPL RGSVESLNVS VACGICLYEV QRQREAPAPS
Length:250
Mass (Da):27,140
Last modified:June 1, 2003 - v1
Checksum:iB33B27EF48177F4A
GO

Sequence cautioni

The sequence AAO90507 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO90507.2. Different initiation.
RefSeqiNP_819993.2. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO90507; AAO90507; CBU_0986.
GeneIDi1208881.
KEGGicbu:CBU_0986.
PATRICifig|227377.7.peg.982.

Similar proteinsi

Entry informationi

Entry nameiRLMB_COXBU
AccessioniPrimary (citable) accession number: Q83CW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: June 1, 2003
Last modified: November 22, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families