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Protein

Uracil-DNA glycosylase

Gene

ung

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.UniRule annotation

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei67Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylaseUniRule annotation (EC:3.2.2.27UniRule annotation)
Short name:
UDGUniRule annotation
Gene namesi
Name:ungUniRule annotation
Ordered Locus Names:CBU_0988
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
Proteomesi
  • UP000002671 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001760891 – 229Uracil-DNA glycosylaseAdd BLAST229

Proteomic databases

PRIDEiQ83CW4.

Interactioni

Protein-protein interaction databases

STRINGi227377.CBU_0988.

Structurei

Secondary structure

1229
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 13Combined sources4
Helixi15 – 19Combined sources5
Helixi21 – 35Combined sources15
Beta strandi40 – 42Combined sources3
Helixi44 – 46Combined sources3
Helixi49 – 53Combined sources5
Helixi56 – 58Combined sources3
Beta strandi61 – 67Combined sources7
Turni72 – 74Combined sources3
Beta strandi76 – 80Combined sources5
Helixi90 – 103Combined sources14
Helixi114 – 118Combined sources5
Beta strandi121 – 128Combined sources8
Turni135 – 140Combined sources6
Helixi143 – 153Combined sources11
Helixi154 – 156Combined sources3
Beta strandi162 – 167Combined sources6
Helixi168 – 172Combined sources5
Helixi173 – 176Combined sources4
Beta strandi182 – 187Combined sources6
Helixi204 – 214Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TR7X-ray2.20A1-229[»]
ProteinModelPortaliQ83CW4.
SMRiQ83CW4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uracil-DNA glycosylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D5S. Bacteria.
COG0692. LUCA.
HOGENOMiHOG000229528.
KOiK03648.
OMAiIALIPKN.

Family and domain databases

CDDicd10027. UDG_F1. 1 hit.
Gene3Di3.40.470.10. 1 hit.
HAMAPiMF_00148. UDG. 1 hit.
InterProiIPR002043. UDG_fam1.
IPR018085. Ura-DNA_Glyclase_AS.
IPR005122. Uracil-DNA_glycosylase-like.
[Graphical view]
PANTHERiPTHR11264. PTHR11264. 1 hit.
PfamiPF03167. UDG. 1 hit.
[Graphical view]
SMARTiSM00986. UDG. 1 hit.
[Graphical view]
SUPFAMiSSF52141. SSF52141. 1 hit.
TIGRFAMsiTIGR00628. ung. 1 hit.
PROSITEiPS00130. U_DNA_GLYCOSYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q83CW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTMAETQTW QTVLGEEKQE PYFQEILDFV KKERKAGKII YPPQKDIFNA
60 70 80 90 100
LKLTPYEAIK VVILGQDPYH GPNQAHGLAF SVRPGVPAPP SLQNIFKELH
110 120 130 140 150
ADLGVSIPSH GFLEKWAKQG VLLLNAALTV EAGKPQSHAN IGWHRFTDKV
160 170 180 190 200
IESLNDHPEG IVFLLWGSYA QKKSQLITNL RHRILKAPHP SPLSAARGFL
210 220
GCRHFSKANQ LLHEMGRGEI DWALDEKVS
Length:229
Mass (Da):25,667
Last modified:June 1, 2003 - v1
Checksum:iA1B27E419D025552
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO90509.1.
RefSeqiNP_819995.1. NC_002971.3.
WP_010957938.1. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO90509; AAO90509; CBU_0988.
GeneIDi1208883.
KEGGicbu:CBU_0988.
PATRICi17930699. VBICoxBur82552_0984.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO90509.1.
RefSeqiNP_819995.1. NC_002971.3.
WP_010957938.1. NC_002971.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TR7X-ray2.20A1-229[»]
ProteinModelPortaliQ83CW4.
SMRiQ83CW4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi227377.CBU_0988.

Proteomic databases

PRIDEiQ83CW4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO90509; AAO90509; CBU_0988.
GeneIDi1208883.
KEGGicbu:CBU_0988.
PATRICi17930699. VBICoxBur82552_0984.

Phylogenomic databases

eggNOGiENOG4105D5S. Bacteria.
COG0692. LUCA.
HOGENOMiHOG000229528.
KOiK03648.
OMAiIALIPKN.

Family and domain databases

CDDicd10027. UDG_F1. 1 hit.
Gene3Di3.40.470.10. 1 hit.
HAMAPiMF_00148. UDG. 1 hit.
InterProiIPR002043. UDG_fam1.
IPR018085. Ura-DNA_Glyclase_AS.
IPR005122. Uracil-DNA_glycosylase-like.
[Graphical view]
PANTHERiPTHR11264. PTHR11264. 1 hit.
PfamiPF03167. UDG. 1 hit.
[Graphical view]
SMARTiSM00986. UDG. 1 hit.
[Graphical view]
SUPFAMiSSF52141. SSF52141. 1 hit.
TIGRFAMsiTIGR00628. ung. 1 hit.
PROSITEiPS00130. U_DNA_GLYCOSYLASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUNG_COXBU
AccessioniPrimary (citable) accession number: Q83CW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.