Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Uracil-DNA glycosylase

Gene

ung

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.UniRule annotation

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei67 – 671Proton acceptorUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

DNA damage, DNA repair

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-981-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylaseUniRule annotation (EC:3.2.2.27UniRule annotation)
Short name:
UDGUniRule annotation
Gene namesi
Name:ungUniRule annotation
Ordered Locus Names:CBU_0988
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
Proteomesi
  • UP000002671 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229Uracil-DNA glycosylasePRO_0000176089Add
BLAST

Proteomic databases

PRIDEiQ83CW4.

Interactioni

Protein-protein interaction databases

STRINGi227377.CBU_0988.

Structurei

Secondary structure

1
229
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi10 – 134Combined sources
Helixi15 – 195Combined sources
Helixi21 – 3515Combined sources
Beta strandi40 – 423Combined sources
Helixi44 – 463Combined sources
Helixi49 – 535Combined sources
Helixi56 – 583Combined sources
Beta strandi61 – 677Combined sources
Turni72 – 743Combined sources
Beta strandi76 – 805Combined sources
Helixi90 – 10314Combined sources
Helixi114 – 1185Combined sources
Beta strandi121 – 1288Combined sources
Turni135 – 1406Combined sources
Helixi143 – 15311Combined sources
Helixi154 – 1563Combined sources
Beta strandi162 – 1676Combined sources
Helixi168 – 1725Combined sources
Helixi173 – 1764Combined sources
Beta strandi182 – 1876Combined sources
Helixi204 – 21411Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3TR7X-ray2.20A1-229[»]
ProteinModelPortaliQ83CW4.
SMRiQ83CW4. Positions 9-222.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uracil-DNA glycosylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D5S. Bacteria.
COG0692. LUCA.
HOGENOMiHOG000229528.
KOiK03648.
OMAiIALIPKN.
OrthoDBiEOG6MSS63.

Family and domain databases

Gene3Di3.40.470.10. 1 hit.
HAMAPiMF_00148. UDG.
InterProiIPR018085. Ura-DNA_Glyclase_AS.
IPR002043. Ura_DNA_glycsylse.
IPR005122. Uracil-DNA_glycosylase-like.
[Graphical view]
PANTHERiPTHR11264. PTHR11264. 1 hit.
PfamiPF03167. UDG. 1 hit.
[Graphical view]
SMARTiSM00986. UDG. 1 hit.
[Graphical view]
SUPFAMiSSF52141. SSF52141. 1 hit.
TIGRFAMsiTIGR00628. ung. 1 hit.
PROSITEiPS00130. U_DNA_GLYCOSYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q83CW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTMAETQTW QTVLGEEKQE PYFQEILDFV KKERKAGKII YPPQKDIFNA
60 70 80 90 100
LKLTPYEAIK VVILGQDPYH GPNQAHGLAF SVRPGVPAPP SLQNIFKELH
110 120 130 140 150
ADLGVSIPSH GFLEKWAKQG VLLLNAALTV EAGKPQSHAN IGWHRFTDKV
160 170 180 190 200
IESLNDHPEG IVFLLWGSYA QKKSQLITNL RHRILKAPHP SPLSAARGFL
210 220
GCRHFSKANQ LLHEMGRGEI DWALDEKVS
Length:229
Mass (Da):25,667
Last modified:June 1, 2003 - v1
Checksum:iA1B27E419D025552
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO90509.1.
RefSeqiNP_819995.1. NC_002971.3.
WP_010957938.1. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO90509; AAO90509; CBU_0988.
GeneIDi1208883.
KEGGicbu:CBU_0988.
PATRICi17930699. VBICoxBur82552_0984.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO90509.1.
RefSeqiNP_819995.1. NC_002971.3.
WP_010957938.1. NC_002971.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3TR7X-ray2.20A1-229[»]
ProteinModelPortaliQ83CW4.
SMRiQ83CW4. Positions 9-222.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi227377.CBU_0988.

Proteomic databases

PRIDEiQ83CW4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO90509; AAO90509; CBU_0988.
GeneIDi1208883.
KEGGicbu:CBU_0988.
PATRICi17930699. VBICoxBur82552_0984.

Phylogenomic databases

eggNOGiENOG4105D5S. Bacteria.
COG0692. LUCA.
HOGENOMiHOG000229528.
KOiK03648.
OMAiIALIPKN.
OrthoDBiEOG6MSS63.

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-981-MONOMER.

Family and domain databases

Gene3Di3.40.470.10. 1 hit.
HAMAPiMF_00148. UDG.
InterProiIPR018085. Ura-DNA_Glyclase_AS.
IPR002043. Ura_DNA_glycsylse.
IPR005122. Uracil-DNA_glycosylase-like.
[Graphical view]
PANTHERiPTHR11264. PTHR11264. 1 hit.
PfamiPF03167. UDG. 1 hit.
[Graphical view]
SMARTiSM00986. UDG. 1 hit.
[Graphical view]
SUPFAMiSSF52141. SSF52141. 1 hit.
TIGRFAMsiTIGR00628. ung. 1 hit.
PROSITEiPS00130. U_DNA_GLYCOSYLASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiUNG_COXBU
AccessioniPrimary (citable) accession number: Q83CW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: June 1, 2003
Last modified: November 11, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.