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Protein

Protoheme IX farnesyltransferase

Gene

cyoE

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. protoheme IX farnesyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. heme O biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Heme biosynthesis

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-987-MONOMER.
UniPathwayiUPA00834; UER00712.

Names & Taxonomyi

Protein namesi
Recommended name:
Protoheme IX farnesyltransferaseUniRule annotation (EC:2.5.1.-UniRule annotation)
Alternative name(s):
Heme B farnesyltransferaseUniRule annotation
Heme O synthaseUniRule annotation
Gene namesi
Name:cyoEUniRule annotation
Ordered Locus Names:CBU_0996
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei28 – 4821HelicalUniRule annotationAdd
BLAST
Transmembranei52 – 7221HelicalUniRule annotationAdd
BLAST
Transmembranei102 – 12221HelicalUniRule annotationAdd
BLAST
Transmembranei123 – 14321HelicalUniRule annotationAdd
BLAST
Transmembranei150 – 17021HelicalUniRule annotationAdd
BLAST
Transmembranei176 – 19621HelicalUniRule annotationAdd
BLAST
Transmembranei221 – 24121HelicalUniRule annotationAdd
BLAST
Transmembranei243 – 26321HelicalUniRule annotationAdd
BLAST
Transmembranei282 – 30221HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Protoheme IX farnesyltransferasePRO_0000326889Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi227377.CBU_0996.

Family & Domainsi

Sequence similaritiesi

Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0109.
HOGENOMiHOG000237291.
KOiK02301.
OMAiGEHYTKV.
OrthoDBiEOG6DVJQB.

Family and domain databases

HAMAPiMF_00154. CyoE_CtaB.
InterProiIPR006369. Protohaem_IX_farnesylTrfase.
IPR000537. UbiA_prenyltransferase.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01473. cyoE_ctaB. 1 hit.
PROSITEiPS00943. UBIA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q83CV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTRTEIVST TQTSATWRDY FQLCKPRVVL LMLLTAIVGM CLASPGIVSW
60 70 80 90 100
RVFLFGNLGI ALAASSAAAI NHLLEHHLDK LMRRTYRRPI VQGKINRKNA
110 120 130 140 150
AIFAAILCIL SMIILIAFVN LLTALLTFIT LIGYAGFYTL YLKHATPQNI
160 170 180 190 200
VIGGLAGAAP PLLGWVAVTG HIDPPALILL LIIFLWTPPH FWALAIHRID
210 220 230 240 250
DYAKANIPML PNTHGIIYTK INILLYTLLL TAISFLPFVI MTSGWIYFSS
260 270 280 290 300
VCLLNLGFLY WAIRLLTSQR KEIPMRTFQY SIWYLMLLFT ALLVDHYVYL

ALKLY
Length:305
Mass (Da):34,456
Last modified:June 1, 2003 - v1
Checksum:i4E36FD3728B88F1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO90517.1.
RefSeqiNP_820003.1. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO90517; AAO90517; CBU_0996.
GeneIDi1208892.
KEGGicbu:CBU_0996.
PATRICi17930711. VBICoxBur82552_0989.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO90517.1.
RefSeqiNP_820003.1. NC_002971.3.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi227377.CBU_0996.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO90517; AAO90517; CBU_0996.
GeneIDi1208892.
KEGGicbu:CBU_0996.
PATRICi17930711. VBICoxBur82552_0989.

Phylogenomic databases

eggNOGiCOG0109.
HOGENOMiHOG000237291.
KOiK02301.
OMAiGEHYTKV.
OrthoDBiEOG6DVJQB.

Enzyme and pathway databases

UniPathwayiUPA00834; UER00712.
BioCyciCBUR227377:GJ7S-987-MONOMER.

Family and domain databases

HAMAPiMF_00154. CyoE_CtaB.
InterProiIPR006369. Protohaem_IX_farnesylTrfase.
IPR000537. UbiA_prenyltransferase.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01473. cyoE_ctaB. 1 hit.
PROSITEiPS00943. UBIA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiCYOE_COXBU
AccessioniPrimary (citable) accession number: Q83CV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2003
Last modified: January 7, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.