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Q83CV6

- CYOE_COXBU

UniProt

Q83CV6 - CYOE_COXBU

Protein

Protoheme IX farnesyltransferase

Gene

cyoE

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. protoheme IX farnesyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. heme O biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Heme biosynthesis

    Enzyme and pathway databases

    BioCyciCBUR227377:GJ7S-987-MONOMER.
    UniPathwayiUPA00834; UER00712.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protoheme IX farnesyltransferaseUniRule annotation (EC:2.5.1.-UniRule annotation)
    Alternative name(s):
    Heme B farnesyltransferaseUniRule annotation
    Heme O synthaseUniRule annotation
    Gene namesi
    Name:cyoEUniRule annotation
    Ordered Locus Names:CBU_0996
    OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
    Taxonomic identifieri227377 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
    ProteomesiUP000002671: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 305305Protoheme IX farnesyltransferasePRO_0000326889Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi227377.CBU_0996.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei28 – 4821HelicalUniRule annotationAdd
    BLAST
    Transmembranei52 – 7221HelicalUniRule annotationAdd
    BLAST
    Transmembranei102 – 12221HelicalUniRule annotationAdd
    BLAST
    Transmembranei123 – 14321HelicalUniRule annotationAdd
    BLAST
    Transmembranei150 – 17021HelicalUniRule annotationAdd
    BLAST
    Transmembranei176 – 19621HelicalUniRule annotationAdd
    BLAST
    Transmembranei221 – 24121HelicalUniRule annotationAdd
    BLAST
    Transmembranei243 – 26321HelicalUniRule annotationAdd
    BLAST
    Transmembranei282 – 30221HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0109.
    HOGENOMiHOG000237291.
    KOiK02301.
    OMAiFKYSIGY.
    OrthoDBiEOG6DVJQB.

    Family and domain databases

    HAMAPiMF_00154. CyoE_CtaB.
    InterProiIPR006369. Protohaem_IX_farnesylTrfase.
    IPR000537. UbiA_prenyltransferase.
    [Graphical view]
    PfamiPF01040. UbiA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01473. cyoE_ctaB. 1 hit.
    PROSITEiPS00943. UBIA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q83CV6-1 [UniParc]FASTAAdd to Basket

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    MRTRTEIVST TQTSATWRDY FQLCKPRVVL LMLLTAIVGM CLASPGIVSW    50
    RVFLFGNLGI ALAASSAAAI NHLLEHHLDK LMRRTYRRPI VQGKINRKNA 100
    AIFAAILCIL SMIILIAFVN LLTALLTFIT LIGYAGFYTL YLKHATPQNI 150
    VIGGLAGAAP PLLGWVAVTG HIDPPALILL LIIFLWTPPH FWALAIHRID 200
    DYAKANIPML PNTHGIIYTK INILLYTLLL TAISFLPFVI MTSGWIYFSS 250
    VCLLNLGFLY WAIRLLTSQR KEIPMRTFQY SIWYLMLLFT ALLVDHYVYL 300
    ALKLY 305
    Length:305
    Mass (Da):34,456
    Last modified:June 1, 2003 - v1
    Checksum:i4E36FD3728B88F1D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO90517.1.
    RefSeqiNP_820003.1. NC_002971.3.

    Genome annotation databases

    EnsemblBacteriaiAAO90517; AAO90517; CBU_0996.
    GeneIDi1208892.
    KEGGicbu:CBU_0996.
    PATRICi17930711. VBICoxBur82552_0989.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO90517.1 .
    RefSeqi NP_820003.1. NC_002971.3.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 227377.CBU_0996.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO90517 ; AAO90517 ; CBU_0996 .
    GeneIDi 1208892.
    KEGGi cbu:CBU_0996.
    PATRICi 17930711. VBICoxBur82552_0989.

    Phylogenomic databases

    eggNOGi COG0109.
    HOGENOMi HOG000237291.
    KOi K02301.
    OMAi FKYSIGY.
    OrthoDBi EOG6DVJQB.

    Enzyme and pathway databases

    UniPathwayi UPA00834 ; UER00712 .
    BioCyci CBUR227377:GJ7S-987-MONOMER.

    Family and domain databases

    HAMAPi MF_00154. CyoE_CtaB.
    InterProi IPR006369. Protohaem_IX_farnesylTrfase.
    IPR000537. UbiA_prenyltransferase.
    [Graphical view ]
    Pfami PF01040. UbiA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01473. cyoE_ctaB. 1 hit.
    PROSITEi PS00943. UBIA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RSA 493 / Nine Mile phase I.

    Entry informationi

    Entry nameiCYOE_COXBU
    AccessioniPrimary (citable) accession number: Q83CV6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Coxiella burnetii
      Coxiella burnetii (strain RSA 493): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3