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Q83CV6 (CYOE_COXBU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protoheme IX farnesyltransferase

EC=2.5.1.-
Alternative name(s):
Heme B farnesyltransferase
Heme O synthase
Gene names
Name:cyoE
Ordered Locus Names:CBU_0996
OrganismCoxiella burnetii (strain RSA 493 / Nine Mile phase I) [Reference proteome] [HAMAP]
Taxonomic identifier227377 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella

Protein attributes

Sequence length305 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group By similarity. HAMAP-Rule MF_00154

Pathway

Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1. HAMAP-Rule MF_00154

Subcellular location

Cell inner membrane; Multi-pass membrane protein Potential HAMAP-Rule MF_00154.

Miscellaneous

Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature By similarity.

Sequence similarities

Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.

Ontologies

Keywords
   Biological processHeme biosynthesis
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processheme O biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprotoheme IX farnesyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 305305Protoheme IX farnesyltransferase HAMAP-Rule MF_00154
PRO_0000326889

Regions

Transmembrane28 – 4821Helical; Potential
Transmembrane52 – 7221Helical; Potential
Transmembrane102 – 12221Helical; Potential
Transmembrane123 – 14321Helical; Potential
Transmembrane150 – 17021Helical; Potential
Transmembrane176 – 19621Helical; Potential
Transmembrane221 – 24121Helical; Potential
Transmembrane243 – 26321Helical; Potential
Transmembrane282 – 30221Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q83CV6 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 4E36FD3728B88F1D

FASTA30534,456
        10         20         30         40         50         60 
MRTRTEIVST TQTSATWRDY FQLCKPRVVL LMLLTAIVGM CLASPGIVSW RVFLFGNLGI 

        70         80         90        100        110        120 
ALAASSAAAI NHLLEHHLDK LMRRTYRRPI VQGKINRKNA AIFAAILCIL SMIILIAFVN 

       130        140        150        160        170        180 
LLTALLTFIT LIGYAGFYTL YLKHATPQNI VIGGLAGAAP PLLGWVAVTG HIDPPALILL 

       190        200        210        220        230        240 
LIIFLWTPPH FWALAIHRID DYAKANIPML PNTHGIIYTK INILLYTLLL TAISFLPFVI 

       250        260        270        280        290        300 
MTSGWIYFSS VCLLNLGFLY WAIRLLTSQR KEIPMRTFQY SIWYLMLLFT ALLVDHYVYL 


ALKLY 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016828 Genomic DNA. Translation: AAO90517.1.
RefSeqNP_820003.1. NC_002971.3.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING227377.CBU_0996.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO90517; AAO90517; CBU_0996.
GeneID1208892.
KEGGcbu:CBU_0996.
PATRIC17930711. VBICoxBur82552_0989.

Phylogenomic databases

eggNOGCOG0109.
HOGENOMHOG000237291.
KOK02301.
OMAGMWTLYT.
OrthoDBEOG6DVJQB.
ProtClustDBPRK04375.

Enzyme and pathway databases

BioCycCBUR227377:GJ7S-987-MONOMER.
UniPathwayUPA00834; UER00712.

Family and domain databases

HAMAPMF_00154. CyoE_CtaB.
InterProIPR006369. Protohaem_IX_farnesylTrfase.
IPR000537. UbiA_prenyltransferase.
[Graphical view]
PfamPF01040. UbiA. 1 hit.
[Graphical view]
TIGRFAMsTIGR01473. cyoE_ctaB. 1 hit.
PROSITEPS00943. UBIA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCYOE_COXBU
AccessionPrimary (citable) accession number: Q83CV6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2003
Last modified: February 19, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Coxiella burnetii

Coxiella burnetii (strain RSA 493): entries and gene names