Q83CV2 (LOLD_COXBU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lipoprotein-releasing system ATP-binding protein LolD
EC=3.6.3.-

Gene names

Name:	lolD
Ordered Locus Names:	CBU_1000

Organism

Coxiella burnetii (strain RSA 493 / Nine Mile phase I) [Reference proteome] [HAMAP]

Taxonomic identifier

227377 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella › Coxiella burnetii

Protein attributes

Sequence length	233 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner By similarity.
Subunit structure	The complex is composed of two ATP-binding proteins (LolD) and two transmembrane proteins (LolC and LolE) By similarity.
Subcellular location	Cell inner membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family. [View classification] Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC
Cellular_component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: InterPro lipoprotein transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 233	233	Lipoprotein-releasing system ATP-binding protein LolD		PRO_0000092433
Regions
	Domain	7 – 233	227	ABC transporter
	Nucleotide binding	43 – 50	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q83CV2 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: D670B0CB28758757	FASTA	233	25,832
	10 20 30 40 50 60 MNNAPVIHCE KLSKTYVEGK LRVPVLHEVE FSVAPGERIA IVGASGAGKS TFLQLLGGLD 70 80 90 100 110 120 KPSNGKIWVN GNDINQLSER EKGLLRNQHL GFVYQFHHLL PEFNALENVC IPLLVRGGIK 130 140 150 160 170 180 PKHARQKASA YLEKVGLSHR QKHRVGELSG GEKQRVALAR ALVTEPCCVL ADEPTGNLDQ 190 200 210 220 230 KTAEQVADLT LQLNRSLNIS FVIVTHNREF ADKMDRVLLL DKGQLQSESE RNH

References

[1]

"Complete genome sequence of the Q-fever pathogen, Coxiella burnetii." Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A. , Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E., Fraser C.M., Heidelberg J.F. Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RSA 493 / Nine Mile phase I.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016828 Genomic DNA. Translation: AAO90521.1.
RefSeq	NP_820007.1. NC_002971.3.
3D structure databases
ProteinModelPortal	Q83CV2.
ModBase	Search...
Protein-protein interaction databases
STRING	227377.CBU_1000.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAO90521; AAO90521; CBU_1000.
GeneID	1208896.
KEGG	cbu:CBU_1000.
PATRIC	17930719. VBICoxBur82552_0993.
Phylogenomic databases
eggNOG	COG1136.
KO	K09810.
OMA	PLYIRRV.
ProtClustDB	CLSK914469.
Enzyme and pathway databases
BioCyc	CBUR227377:GJ7S-991-MONOMER.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR015854. ABC_transpr_LolD. IPR011924. LolD_lipo_ATP-bd. [Graphical view]
Pfam	PF00005. ABC_tran. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
TIGRFAMs	TIGR02211. LolD_lipo_ex. 1 hit.
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. PS51244. LOLD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LOLD_COXBU

Accession

Primary (citable) accession number: Q83CV2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 24, 2004
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program