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Q83CG2 (TRPA_COXBU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan synthase alpha chain

EC=4.2.1.20
Gene names
Name:trpA
Ordered Locus Names:CBU_1156
OrganismCoxiella burnetii (strain RSA 493 / Nine Mile phase I) [Reference proteome] [HAMAP]
Taxonomic identifier227377 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella

Protein attributes

Sequence length267 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate By similarity. HAMAP-Rule MF_00131

Catalytic activity

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O. HAMAP-Rule MF_00131

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5. HAMAP-Rule MF_00131

Subunit structure

Tetramer of two alpha and two beta chains By similarity.

Sequence similarities

Belongs to the TrpA family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
Tryptophan biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functiontryptophan synthase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 267267Tryptophan synthase alpha chain HAMAP-Rule MF_00131
PRO_0000098774

Sites

Active site441Proton acceptor By similarity
Active site551Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q83CG2 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: E143E41C19C0E858

FASTA26728,924
        10         20         30         40         50         60 
MNRIEQQFKK SPAYVAYLTA GDGGLERSLE SLLALAKGGV NILEVGVPFS DPVADGPVIQ 

        70         80         90        100        110        120 
EASIRALAQG TTLHDVLTLI TSFRQHSEIP IILFTYFNPL LAAGDKIYQQ MKSAGVDGCL 

       130        140        150        160        170        180 
VVDLPVEEAA PHLTACKTAK IAPILLISPS TTQERLKKIN EHGEGMLYYV CRPGTTGVRA 

       190        200        210        220        230        240 
TLPENFPAKM NQIKSMTSLP IVTGFGIANR KMAAQALQYA DGFVIGSLFV KAIAEGISKN 

       250        260 
ALTRLAQSLN PHYPNLRLIT PFRKKTF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016828 Genomic DNA. Translation: AAO90667.1.
RefSeqNP_820153.1. NC_002971.3.

3D structure databases

ProteinModelPortalQ83CG2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING227377.CBU_1156.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO90667; AAO90667; CBU_1156.
GeneID1209058.
KEGGcbu:CBU_1156.
PATRIC17931051. VBICoxBur82552_1153.

Phylogenomic databases

eggNOGCOG0159.
HOGENOMHOG000223814.
KOK01695.
OMANSEGYTY.
OrthoDBEOG6RVG0K.

Enzyme and pathway databases

BioCycCBUR227377:GJ7S-1145-MONOMER.
UniPathwayUPA00035; UER00044.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00131. Trp_synth_alpha.
InterProIPR013785. Aldolase_TIM.
IPR011060. RibuloseP-bd_barrel.
IPR018204. Trp_synthase_alpha_AS.
IPR002028. Trp_synthase_suA.
[Graphical view]
PfamPF00290. Trp_syntA. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR00262. trpA. 1 hit.
PROSITEPS00167. TRP_SYNTHASE_ALPHA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRPA_COXBU
AccessionPrimary (citable) accession number: Q83CG2
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Coxiella burnetii

Coxiella burnetii (strain RSA 493): entries and gene names