Q83CA6DAPA_COXBU4-hydroxy-tetrahydrodipicolinate synthaseHTPA synthase4.3.3.7dapACBU_1222Coxiella burnetii (strain RSA 493 / Nine Mile phase I)BacteriaPseudomonadotaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiellaComplete genome sequence of the Q-fever pathogen, Coxiella burnetii.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2OAmino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.Homotetramer; dimer of dimers.CytoplasmBelongs to the DapA family.Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.Amino-acid biosynthesisCytoplasmDiaminopimelate biosynthesisLyaseLysine biosynthesisReference proteomeSchiff basepyruvatepyruvateMFNGSLVALVTPMQENGEIDYSNLKELVEWHLENDTDGLVILGTTGESPTITAEERHKIIRQVVDQVNKKIPIIVGTGANSTVHTIEMTQQAMELGADAALIVTPYYNKPTQEGLFQYFKTIAEAVPIAQILYNVPSRTACDLLPETVIRIAKCSNVVGLKEATGDIQRVKQLKAEDLDLLSGDDKTAMDFMLAGGKGVISVVANVVPKPYHAFCITAVSGNVELAKKENDQLSPLYDSLFVESNPIPVKWALSQMGVIPKGIRLPLTPLSERYHAKVRESLQQVGIKC
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