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Protein

Glycerol-3-phosphate acyltransferase

Gene

plsY

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO4) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.

Catalytic activityi

Acyl-phosphate + sn-glycerol 3-phosphate = 1-acyl-sn-glycerol 3-phosphate + phosphate.

Pathwayi: phospholipid metabolism

This protein is involved in the pathway phospholipid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway phospholipid metabolism and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00085.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate acyltransferase
Alternative name(s):
Acyl-PO4 G3P acyltransferase
Acyl-phosphate--glycerol-3-phosphate acyltransferase
G3P acyltransferase (EC:2.3.1.n3)
Short name:
GPAT
Lysophosphatidic acid synthase
Short name:
LPA synthase
Gene namesi
Name:plsY
Ordered Locus Names:CBU_1239
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
Proteomesi
  • UP000002671 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane ; Multi-pass membrane protein

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2 – 22HelicalAdd BLAST21
Transmembranei51 – 71HelicalAdd BLAST21
Transmembranei78 – 98HelicalAdd BLAST21
Transmembranei112 – 132HelicalAdd BLAST21
Transmembranei154 – 174HelicalAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001883481 – 193Glycerol-3-phosphate acyltransferaseAdd BLAST193

Interactioni

Subunit structurei

Probably interacts with PlsX.

Protein-protein interaction databases

STRINGi227377.CBU_1239.

Family & Domainsi

Sequence similaritiesi

Belongs to the PlsY family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105K7Z. Bacteria.
COG0344. LUCA.
HOGENOMiHOG000283806.
KOiK08591.
OMAiHSQYPKI.

Family and domain databases

HAMAPiMF_01043. PlsY. 1 hit.
InterProiView protein in InterPro
IPR003811. G3P_acylTferase_PlsY.
PANTHERiPTHR30309. PTHR30309. 1 hit.
PfamiView protein in Pfam
PF02660. G3P_acyltransf. 1 hit.
SMARTiView protein in SMART
SM01207. G3P_acyltransf. 1 hit.
TIGRFAMsiTIGR00023. TIGR00023. 1 hit.

Sequencei

Sequence statusi: Complete.

Q83C89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFIISIIIA YLLGSLSFAV IVAKLMKLPD PRTTGSGNAG ATNMLRVGGR
60 70 80 90 100
QAAFYVLLGD AAKGLIAVLI ARFLNVQGVS LAFVGLVAVL GHLFPVYFKF
110 120 130 140 150
RGGKGVATMM GVLLGLSFWI GLFVIATWVI VVSIFRYSSV AALVSAVAAP
160 170 180 190
IYTIIAGRTD YLFPVLIIAI LIIWKHWENF QRLRKGTEDK VKL
Length:193
Mass (Da):20,861
Last modified:June 1, 2003 - v1
Checksum:iB775A98CD32B5D83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO90748.1.
RefSeqiNP_820234.1. NC_002971.3.
WP_005770791.1. NZ_CDBG01000001.1.

Genome annotation databases

EnsemblBacteriaiAAO90748; AAO90748; CBU_1239.
GeneIDi1209144.
31483939.
KEGGicbu:CBU_1239.
PATRICifig|227377.7.peg.1230.

Similar proteinsi

Entry informationi

Entry nameiPLSY_COXBU
AccessioniPrimary (citable) accession number: Q83C89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: June 1, 2003
Last modified: June 7, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families