Reviewed,
UniProtKB/Swiss-Prot Q83C87 (MDH_COXBU)
Last modified
June 16, 2009.
Version 45.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Malate dehydrogenase EC=1.1.1.37 | ||||
| Gene names |
| ||||
| Organism | Coxiella burnetii [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 777 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella |
Protein attributes
| Sequence length | 328 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the reversible oxidation of malate to oxaloacetate By similarity. |
| Catalytic activity | (S)-malate + NAD+ = oxaloacetate + NADH. HAMAP MF_01517 |
| Subunit structure | Homodimer By similarity. |
| Sequence similarities | Belongs to the LDH/MDH superfamily. MDH type 2 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Tricarboxylic acid cycle |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | glycolysis Inferred from electronic annotation. Source: InterPro malate metabolic processInferred from electronic annotation. Source: InterPro oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycleInferred from electronic annotation. Source: HAMAP |
| Molecular function | L-malate dehydrogenase activity Inferred from electronic annotation. Source: HAMAP bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 328 | 328 | Malate dehydrogenase HAMAP MF_01517 | PRO_0000113366 | |||||
Regions | |||||||||
| Nucleotide binding | 11 – 17 | 7 | NAD By similarity | ||||||
| Nucleotide binding | 129 – 131 | 3 | NAD By similarity | ||||||
Sites | |||||||||
| Active site | 187 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 92 | 1 | Substrate By similarity | ||||||
| Binding site | 98 | 1 | Substrate By similarity | ||||||
| Binding site | 105 | 1 | NAD By similarity | ||||||
| Binding site | 112 | 1 | NAD By similarity | ||||||
| Binding site | 131 | 1 | Substrate By similarity | ||||||
| Binding site | 162 | 1 | Substrate By similarity | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "Complete genome sequence of the Q-fever pathogen, Coxiella burnetii." Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A. Heidelberg J.F.Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed: 12704232] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nine Mile phase I / RSA 493. |
Cross-references
Sequence databases | |
|---|---|
| AE016828 Genomic DNA. Translation: AAO90750.1. | |
| RefSeq | NP_820236.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1BMD based on UniProtKB P10584. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1209146. |
| GenomeReviews | Gene locus CBU_1241 in contig AE016828_GR. |
| KEGG | cbu:CBU_1241. |
| NMPDR | fig|227377.1.peg.1180. |
| TIGR | CBU_1241. |
Phylogenomic databases | |
| HOGENOM | Q83C87. |
| OMA | Q83C87. MIIWGNH. |
Enzyme and pathway databases | |
| BioCyc | CBUR227377:CBU_1241-MON. |
| BRENDA | 1.1.1.37. 256353. |
Family and domain databases | |
| HAMAP | MF_01517. [Tree] |
| InterPro | IPR001557. L-lactate/malate_DH. IPR001236. Lactate/malate_DH. IPR015955. Lactate_DH/Glyco_Ohase_4_C. IPR001252. Malate_DH_AS. IPR010945. Malate_DH_SF1. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Gene3D | G3DSA:3.90.110.10. lact_mal_DH. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| PANTHER | PTHR23382. MDH_SF1. 1 hit. |
| Pfam | PF02866. Ldh_1_C. 1 hit. PF00056. Ldh_1_N. 1 hit. [Graphical view] |
| PIRSF | PIRSF000102. Lac_mal_DH. 1 hit. |
| ProDom | PD003052. Mal_dehydrog. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR01759. MalateDH-SF1. 1 hit. |
| PROSITE | PS00068. MDH. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MDH_COXBU | ||||||||
| Accession | Primary (citable) accession number: Q83C87 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Coxiella burnetii Coxiella burnetii (strain RSA 493): entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with


