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Protein

GTPase Der

Gene

der

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GTPase that plays an essential role in the late steps of ribosome biogenesis.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 16GTP 1UniRule annotation8
Nucleotide bindingi56 – 60GTP 1UniRule annotation5
Nucleotide bindingi119 – 122GTP 1UniRule annotation4
Nucleotide bindingi182 – 189GTP 2UniRule annotation8
Nucleotide bindingi229 – 233GTP 2UniRule annotation5
Nucleotide bindingi294 – 297GTP 2UniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processRibosome biogenesis
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase DerUniRule annotation
Alternative name(s):
GTP-binding protein EngAUniRule annotation
Gene namesi
Name:derUniRule annotation
Synonyms:engA
Ordered Locus Names:CBU_1245
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
Proteomesi
  • UP000002671 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001789891 – 443GTPase DerAdd BLAST443

Proteomic databases

PRIDEiQ83C83.

Interactioni

Subunit structurei

Associates with the 50S ribosomal subunit.UniRule annotation

Protein-protein interaction databases

STRINGi227377.CBU_1245.

Structurei

Secondary structure

1443
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 8Combined sources5
Helixi15 – 22Combined sources8
Beta strandi30 – 33Combined sources4
Beta strandi40 – 47Combined sources8
Beta strandi50 – 56Combined sources7
Helixi57 – 59Combined sources3
Helixi74 – 82Combined sources9
Beta strandi84 – 91Combined sources8
Turni92 – 94Combined sources3
Helixi98 – 109Combined sources12
Beta strandi110 – 119Combined sources10
Helixi126 – 130Combined sources5
Helixi131 – 136Combined sources6
Turni146 – 148Combined sources3
Helixi152 – 161Combined sources10
Beta strandi176 – 181Combined sources6
Helixi188 – 195Combined sources8
Beta strandi201 – 203Combined sources3
Beta strandi215 – 220Combined sources6
Beta strandi223 – 228Combined sources6
Helixi233 – 239Combined sources7
Helixi248 – 257Combined sources10
Beta strandi259 – 266Combined sources8
Turni267 – 269Combined sources3
Helixi273 – 285Combined sources13
Beta strandi288 – 294Combined sources7
Helixi301 – 314Combined sources14
Helixi316 – 318Combined sources3
Beta strandi321 – 325Combined sources5
Turni328 – 330Combined sources3
Helixi334 – 336Combined sources3
Helixi337 – 349Combined sources13
Helixi354 – 367Combined sources14
Beta strandi379 – 387Combined sources9
Turni388 – 391Combined sources4
Beta strandi392 – 399Combined sources8
Helixi400 – 402Combined sources3
Helixi405 – 419Combined sources15
Beta strandi427 – 431Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5DN8X-ray1.76A1-443[»]
ProteinModelPortaliQ83C83.
SMRiQ83C83.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 167EngA-type G 1Add BLAST165
Domaini176 – 349EngA-type G 2Add BLAST174
Domaini350 – 434KH-likeUniRule annotationAdd BLAST85

Sequence similaritiesi

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105DKZ. Bacteria.
COG1160. LUCA.
HOGENOMiHOG000242862.
KOiK03977.
OMAiFCNLPQY.

Family and domain databases

Gene3Di1.20.120.430. 2 hits.
3.30.300.20. 1 hit.
HAMAPiMF_00195. GTPase_Der. 1 hit.
InterProiView protein in InterPro
IPR031166. G_ENGA.
IPR016484. GTP-bd_EngA.
IPR006073. GTP_binding_domain.
IPR032859. KH_dom-like.
IPR015946. KH_dom-like_a/b.
IPR027368. MnmE_dom2.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
PfamiView protein in Pfam
PF14714. KH_dom-like. 1 hit.
PF01926. MMR_HSR1. 2 hits.
PIRSFiPIRSF006485. GTP-binding_EngA. 1 hit.
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR03594. GTPase_EngA. 1 hit.
TIGR00231. small_GTP. 2 hits.
PROSITEiView protein in PROSITE
PS51712. G_ENGA. 2 hits.

Sequencei

Sequence statusi: Complete.

Q83C83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPVIAIVGR PNVGKSTLFN YLTKSRAALV ADVPGVTRDR QYGETTIDSQ
60 70 80 90 100
RLLLVDTGGL VDTENKEVAP LAETQVEQAI DESDCILFLV DAKAGLVPAD
110 120 130 140 150
EIIAERLRKK GKKIFLAVNK ADRARAAVVQ SDFYKLGFGE PYVIAAASGR
160 170 180 190 200
GVKDLMTQVL ENLPEEKEVI EKEVGIKIAM IGRPNVGKST LINRLLGEER
210 220 230 240 250
VIVYDQPGTT RDSIYIPFAR NDENYTLIDT AGIRRRAKIQ DYVEKFSMIK
260 270 280 290 300
SLQAMHAADV VIFLLDARQG VTEQDLRLLN RIVEAGVSLI IAVNKWDGLN
310 320 330 340 350
IEERDNVRNA IDRRMPFVDF ARRYFISALH GTGVGKLFRA IQESYQSIQQ
360 370 380 390 400
ELTTGQLTRA LEKAVAEHEP PLVKGRRIRL RYAHLGARHP LTIVVHGKQT
410 420 430 440
KSLPQSYSRY LANYFRKTFN FIGVPVHIKL KTDPNPYEGQ EER
Length:443
Mass (Da):49,707
Last modified:June 1, 2003 - v1
Checksum:i040B36345FD487EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO90754.1.
RefSeqiNP_820240.1. NC_002971.3.
WP_005770802.1. NC_002971.4.

Genome annotation databases

EnsemblBacteriaiAAO90754; AAO90754; CBU_1245.
GeneIDi1209150.
31483945.
KEGGicbu:CBU_1245.
PATRICifig|227377.7.peg.1237.

Similar proteinsi

Entry informationi

Entry nameiDER_COXBU
AccessioniPrimary (citable) accession number: Q83C83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 2003
Last modified: October 25, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families