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Protein

Histidine--tRNA ligase

Gene

hisS

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBUR227377:G1G0B-1231-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine--tRNA ligaseUniRule annotation (EC:6.1.1.21UniRule annotation)
Alternative name(s):
Histidyl-tRNA synthetaseUniRule annotation
Short name:
HisRSUniRule annotation
Gene namesi
Name:hisSUniRule annotation
Ordered Locus Names:CBU_1248
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
Proteomesi
  • UP000002671 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001361491 – 421Histidine--tRNA ligaseAdd BLAST421

Proteomic databases

PRIDEiQ83C80

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi227377.CBU_1248

Structurei

3D structure databases

ProteinModelPortaliQ83C80
SMRiQ83C80
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CUT Bacteria
COG0124 LUCA
HOGENOMiHOG000018072
KOiK01892
OMAiCDFDFIG

Family and domain databases

CDDicd00859 HisRS_anticodon, 1 hit
Gene3Di3.40.50.800, 1 hit
HAMAPiMF_00127 His_tRNA_synth, 1 hit
InterProiView protein in InterPro
IPR006195 aa-tRNA-synth_II
IPR004154 Anticodon-bd
IPR036621 Anticodon-bd_dom_sf
IPR015807 His-tRNA-ligase
IPR004516 HisRS/HisZ
IPR033656 HisRS_anticodon
PANTHERiPTHR43707 PTHR43707, 1 hit
PfamiView protein in Pfam
PF03129 HGTP_anticodon, 1 hit
PIRSFiPIRSF001549 His-tRNA_synth, 1 hit
TIGRFAMsiTIGR00442 hisS, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

Q83C80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKSIQAIRG MSDTLPEEIP YWSFLENACR SVVSAYHYRE IRFPVVEQTA
60 70 80 90 100
LFKRTIGEAT DIVEKEMYTF TDRNGDSLTL RPEGTAGCVR AGIQNGLFYN
110 120 130 140 150
QIQRLWYLGP MFRHERPQKG RYRQFYQLGV ETYGMAGAPI EAELIFMCLR
160 170 180 190 200
LWKALGLESC IHLELNTLGT LDSRNAYRQA LVTYLQSREK ELDEDSRRRL
210 220 230 240 250
HTNPLRILDS KNPDLQPLLA EAPKLIDYLD ETSRRHFDQL RSLLDQAEVP
260 270 280 290 300
FIVNPTLVRG LDYYTHTVFE WVTDQLGAQG TVCAGGRYDN LVELLGGKST
310 320 330 340 350
PAAGFAAGLE RLVLLLRGVQ ECLDKIDIYV VIAGEAVIQE GLLMTEQLRN
360 370 380 390 400
VLPEWVIEAD LSGSSLKSQF KRADKSGAKW ALVIGEEEIK TNTVTLKHLR
410 420
ETVPQKSLTR DTLIPYLKSE G
Length:421
Mass (Da):47,810
Last modified:June 1, 2003 - v1
Checksum:i3394CCD0F9B19736
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA Translation: AAO90757.1
RefSeqiNP_820243.1, NC_002971.3
WP_010958101.1, NC_002971.4

Genome annotation databases

EnsemblBacteriaiAAO90757; AAO90757; CBU_1248
GeneIDi1209153
31483947
KEGGicbu:CBU_1248
PATRICifig|227377.7.peg.1239

Similar proteinsi

Entry informationi

Entry nameiSYH_COXBU
AccessioniPrimary (citable) accession number: Q83C80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: February 28, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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