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Protein

Histidine--tRNA ligase

Gene

hisS

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine--tRNA ligaseUniRule annotation (EC:6.1.1.21UniRule annotation)
Alternative name(s):
Histidyl-tRNA synthetaseUniRule annotation
Short name:
HisRSUniRule annotation
Gene namesi
Name:hisSUniRule annotation
Ordered Locus Names:CBU_1248
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
Proteomesi
  • UP000002671 Componenti: Chromosome

Subcellular locationi

Q83C80:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001361491 – 421Histidine--tRNA ligaseAdd BLAST421

Proteomic databases

PRIDEiQ83C80.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi227377.CBU_1248.

Structurei

3D structure databases

ProteinModelPortaliQ83C80.
SMRiQ83C80.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CUT. Bacteria.
COG0124. LUCA.
HOGENOMiHOG000018072.
KOiK01892.
OMAiCDFDFIG.

Family and domain databases

CDDicd00859. HisRS_anticodon. 1 hit.
Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00127. His_tRNA_synth. 1 hit.
InterProiView protein in InterPro
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR036621. Anticodon-bd_dom_sf.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
IPR033656. HisRS_anticodon.
PANTHERiPTHR43707. PTHR43707. 1 hit.
PfamiView protein in Pfam
PF03129. HGTP_anticodon. 1 hit.
PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00442. hisS. 1 hit.
PROSITEiView protein in PROSITE
PS50862. AA_TRNA_LIGASE_II. 1 hit.

Sequencei

Sequence statusi: Complete.

Q83C80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKSIQAIRG MSDTLPEEIP YWSFLENACR SVVSAYHYRE IRFPVVEQTA
60 70 80 90 100
LFKRTIGEAT DIVEKEMYTF TDRNGDSLTL RPEGTAGCVR AGIQNGLFYN
110 120 130 140 150
QIQRLWYLGP MFRHERPQKG RYRQFYQLGV ETYGMAGAPI EAELIFMCLR
160 170 180 190 200
LWKALGLESC IHLELNTLGT LDSRNAYRQA LVTYLQSREK ELDEDSRRRL
210 220 230 240 250
HTNPLRILDS KNPDLQPLLA EAPKLIDYLD ETSRRHFDQL RSLLDQAEVP
260 270 280 290 300
FIVNPTLVRG LDYYTHTVFE WVTDQLGAQG TVCAGGRYDN LVELLGGKST
310 320 330 340 350
PAAGFAAGLE RLVLLLRGVQ ECLDKIDIYV VIAGEAVIQE GLLMTEQLRN
360 370 380 390 400
VLPEWVIEAD LSGSSLKSQF KRADKSGAKW ALVIGEEEIK TNTVTLKHLR
410 420
ETVPQKSLTR DTLIPYLKSE G
Length:421
Mass (Da):47,810
Last modified:June 1, 2003 - v1
Checksum:i3394CCD0F9B19736
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO90757.1.
RefSeqiNP_820243.1. NC_002971.3.
WP_010958101.1. NC_002971.4.

Genome annotation databases

EnsemblBacteriaiAAO90757; AAO90757; CBU_1248.
GeneIDi1209153.
31483947.
KEGGicbu:CBU_1248.
PATRICifig|227377.7.peg.1239.

Similar proteinsi

Entry informationi

Entry nameiSYH_COXBU
AccessioniPrimary (citable) accession number: Q83C80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: October 25, 2017
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families