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Protein

Nucleoside diphosphate kinase

Gene

ndk

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.UniRule annotation

Catalytic activityi

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei11ATPUniRule annotation1
Binding sitei59ATPUniRule annotation1
Binding sitei87ATPUniRule annotation1
Binding sitei93ATPUniRule annotation1
Binding sitei104ATPUniRule annotation1
Binding sitei114ATPUniRule annotation1
Active sitei117Pros-phosphohistidine intermediateUniRule annotation1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • nucleoside diphosphate kinase activity Source: TIGR

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processNucleotide metabolism
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate kinaseUniRule annotation (EC:2.7.4.6UniRule annotation)
Short name:
NDKUniRule annotation
Short name:
NDP kinaseUniRule annotation
Alternative name(s):
Nucleoside-2-P kinaseUniRule annotation
Gene namesi
Name:ndkUniRule annotation
Ordered Locus Names:CBU_1258
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
Proteomesi
  • UP000002671 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001369741 – 144Nucleoside diphosphate kinaseAdd BLAST144

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ83C71.

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi227377.CBU_1258.

Structurei

3D structure databases

ProteinModelPortaliQ83C71.
SMRiQ83C71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NDK family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UGX. Bacteria.
COG0105. LUCA.
HOGENOMiHOG000224565.
KOiK00940.
OMAiKIVAMKM.

Family and domain databases

Gene3Di3.30.70.141. 2 hits.
HAMAPiMF_00451. NDP_kinase. 1 hit.
InterProiView protein in InterPro
IPR034907. NDK-like_dom.
IPR036850. NDK-like_dom_sf.
IPR001564. Nucleoside_diP_kinase.
IPR023005. Nucleoside_diP_kinase_AS.
PfamiView protein in Pfam
PF00334. NDK. 1 hit.
PRINTSiPR01243. NUCDPKINASE.
SMARTiView protein in SMART
SM00562. NDK. 1 hit.
SUPFAMiSSF54919. SSF54919. 1 hit.
PROSITEiView protein in PROSITE
PS00469. NDP_KINASES. 1 hit.

Sequencei

Sequence statusi: Complete.

Q83C71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIERTLSII KPDAVAKNVI GQIYSRFEKA GLKIIAAKMC HLSKPQAEKF
60 70 80 90 100
YAVHKDRPFY PDLVKFMTQG PVMIQVLEGE NAIVKNREIM GATNPKEALP
110 120 130 140
GTIRADFADS IDANAVHGSD GPETAKEEIA FFFKPDESFN SIGV
Length:144
Mass (Da):15,854
Last modified:June 1, 2003 - v1
Checksum:iCA7629449CB61A2E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO90766.1.
RefSeqiNP_820252.1. NC_002971.3.
WP_010958107.1. NZ_CCYB01000031.1.

Genome annotation databases

EnsemblBacteriaiAAO90766; AAO90766; CBU_1258.
GeneIDi1209163.
KEGGicbu:CBU_1258.
PATRICifig|227377.7.peg.1249.

Similar proteinsi

Entry informationi

Entry nameiNDK_COXBU
AccessioniPrimary (citable) accession number: Q83C71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: June 1, 2003
Last modified: October 25, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families