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Protein

Protein GrpE

Gene

grpE

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.UniRule annotation

GO - Molecular functioni

  1. adenyl-nucleotide exchange factor activity Source: InterPro

GO - Biological processi

  1. protein folding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-1281-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein GrpEUniRule annotation
Alternative name(s):
HSP-70 cofactorUniRule annotation
Gene namesi
Name:grpEUniRule annotation
Ordered Locus Names:CBU_1293
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671 Componenti: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 204204Protein GrpEPRO_0000113779Add
BLAST

Proteomic databases

PRIDEiQ83C41.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi227377.CBU_1293.

Structurei

3D structure databases

ProteinModelPortaliQ83C41.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GrpE family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0576.
HOGENOMiHOG000252084.
KOiK03687.
OMAiCPITINQ.
OrthoDBiEOG6FJNJ9.

Family and domain databases

Gene3Di2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPiMF_01151. GrpE.
InterProiIPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
[Graphical view]
PANTHERiPTHR21237. PTHR21237. 1 hit.
PfamiPF01025. GrpE. 1 hit.
[Graphical view]
PRINTSiPR00773. GRPEPROTEIN.
SUPFAMiSSF51064. SSF51064. 1 hit.
PROSITEiPS01071. GRPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q83C41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSKNNPESE TKAKNKWEKV MEAEEEQEEG RGDGSQEMEP HREGLEFPSR
60 70 80 90 100
EKLEGQLTRM ERKVDEYKTQ YLRAQAEMDN LRKRIEREKA DIIKFGSKQL
110 120 130 140 150
ITDLLPVADS LIHGLESPAS EDPQVKSMRD GMSLTLDLLH NTLAKHGVQV
160 170 180 190 200
INPNPGDPFD PALHEAMSVQ AVPDAKPDTI IQVLQKGYQL NGRVLRAARV

IVAG
Length:204
Mass (Da):22,952
Last modified:May 31, 2003 - v1
Checksum:i9A0B557667133AEF
GO

Sequence cautioni

The sequence AAO90799.2 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO90799.2. Different initiation.
RefSeqiNP_820285.2. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO90799; AAO90799; CBU_1293.
GeneIDi1209198.
KEGGicbu:CBU_1293.
PATRICi17931327. VBICoxBur82552_1288.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO90799.2. Different initiation.
RefSeqiNP_820285.2. NC_002971.3.

3D structure databases

ProteinModelPortaliQ83C41.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi227377.CBU_1293.

Proteomic databases

PRIDEiQ83C41.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO90799; AAO90799; CBU_1293.
GeneIDi1209198.
KEGGicbu:CBU_1293.
PATRICi17931327. VBICoxBur82552_1288.

Phylogenomic databases

eggNOGiCOG0576.
HOGENOMiHOG000252084.
KOiK03687.
OMAiCPITINQ.
OrthoDBiEOG6FJNJ9.

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-1281-MONOMER.

Family and domain databases

Gene3Di2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPiMF_01151. GrpE.
InterProiIPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
[Graphical view]
PANTHERiPTHR21237. PTHR21237. 1 hit.
PfamiPF01025. GrpE. 1 hit.
[Graphical view]
PRINTSiPR00773. GRPEPROTEIN.
SUPFAMiSSF51064. SSF51064. 1 hit.
PROSITEiPS01071. GRPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiGRPE_COXBU
AccessioniPrimary (citable) accession number: Q83C41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2004
Last sequence update: May 31, 2003
Last modified: January 6, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.