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Q83C41 (GRPE_COXBU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein GrpE
Alternative name(s):
HSP-70 cofactor
Gene names
Name:grpE
Ordered Locus Names:CBU_1293
OrganismCoxiella burnetii (strain RSA 493 / Nine Mile phase I) [Reference proteome] [HAMAP]
Taxonomic identifier227377 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella

Protein attributes

Sequence length204 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding By similarity. HAMAP-Rule MF_01151

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01151

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01151.

Sequence similarities

Belongs to the GrpE family.

Sequence caution

The sequence AAO90799.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processStress response
   Cellular componentCytoplasm
   Molecular functionChaperone
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein folding

Inferred from electronic annotation. Source: InterPro

response to stress

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionadenyl-nucleotide exchange factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 204204Protein GrpE HAMAP-Rule MF_01151
PRO_0000113779

Sequences

Sequence LengthMass (Da)Tools
Q83C41 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 9A0B557667133AEF

FASTA20422,952
        10         20         30         40         50         60 
MSSKNNPESE TKAKNKWEKV MEAEEEQEEG RGDGSQEMEP HREGLEFPSR EKLEGQLTRM 

        70         80         90        100        110        120 
ERKVDEYKTQ YLRAQAEMDN LRKRIEREKA DIIKFGSKQL ITDLLPVADS LIHGLESPAS 

       130        140        150        160        170        180 
EDPQVKSMRD GMSLTLDLLH NTLAKHGVQV INPNPGDPFD PALHEAMSVQ AVPDAKPDTI 

       190        200 
IQVLQKGYQL NGRVLRAARV IVAG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016828 Genomic DNA. Translation: AAO90799.2. Different initiation.
RefSeqNP_820285.2. NC_002971.3.

3D structure databases

ProteinModelPortalQ83C41.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING227377.CBU_1293.

Proteomic databases

PRIDEQ83C41.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO90799; AAO90799; CBU_1293.
GeneID1209198.
KEGGcbu:CBU_1293.
PATRIC17931327. VBICoxBur82552_1288.

Phylogenomic databases

eggNOGCOG0576.
HOGENOMHOG000252084.
KOK03687.
OMAARDMIDS.
OrthoDBEOG6FJNJ9.
ProtClustDBPRK14154.

Enzyme and pathway databases

BioCycCBUR227377:GJ7S-1281-MONOMER.

Family and domain databases

Gene3D2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPMF_01151. GrpE.
InterProIPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
[Graphical view]
PANTHERPTHR21237. PTHR21237. 1 hit.
PfamPF01025. GrpE. 1 hit.
[Graphical view]
PRINTSPR00773. GRPEPROTEIN.
SUPFAMSSF51064. SSF51064. 1 hit.
PROSITEPS01071. GRPE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGRPE_COXBU
AccessionPrimary (citable) accession number: Q83C41
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Coxiella burnetii

Coxiella burnetii (strain RSA 493): entries and gene names