ID   IF3_COXBU               Reviewed;         185 AA.
AC   Q83C11;
DT   15-DEC-2003, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 2.
DT   27-MAR-2024, entry version 109.
DE   RecName: Full=Translation initiation factor IF-3 {ECO:0000255|HAMAP-Rule:MF_00080};
GN   Name=infC {ECO:0000255|HAMAP-Rule:MF_00080};
GN   OrderedLocusNames=CBU_1325;
OS   Coxiella burnetii (strain RSA 493 / Nine Mile phase I).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales; Coxiellaceae;
OC   Coxiella.
OX   NCBI_TaxID=227377;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RSA 493 / Nine Mile phase I;
RX   PubMed=12704232; DOI=10.1073/pnas.0931379100;
RA   Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C.,
RA   Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T.,
RA   Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M.,
RA   Lee K.H., Carty H.A., Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E.,
RA   Fraser C.M., Heidelberg J.F.;
RT   "Complete genome sequence of the Q-fever pathogen, Coxiella burnetii.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003).
CC   -!- FUNCTION: IF-3 binds to the 30S ribosomal subunit and shifts the
CC       equilibrium between 70S ribosomes and their 50S and 30S subunits in
CC       favor of the free subunits, thus enhancing the availability of 30S
CC       subunits on which protein synthesis initiation begins.
CC       {ECO:0000255|HAMAP-Rule:MF_00080}.
CC   -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_00080}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00080}.
CC   -!- SIMILARITY: Belongs to the IF-3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_00080}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAO90829.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE016828; AAO90829.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_820315.1; NC_002971.3.
DR   RefSeq; WP_005770939.1; NC_002971.4.
DR   RefSeq; WP_061299200.1; NZ_CDBG01000001.1.
DR   AlphaFoldDB; Q83C11; -.
DR   SMR; Q83C11; -.
DR   STRING; 227377.CBU_1325; -.
DR   EnsemblBacteria; AAO90829; AAO90829; CBU_1325.
DR   GeneID; 1209231; -.
DR   KEGG; cbu:CBU_1325; -.
DR   PATRIC; fig|227377.7.peg.1316; -.
DR   eggNOG; COG0290; Bacteria.
DR   HOGENOM; CLU_054919_3_2_6; -.
DR   OrthoDB; 9806014at2; -.
DR   Proteomes; UP000002671; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0043022; F:ribosome binding; IBA:GO_Central.
DR   GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR   GO; GO:0032790; P:ribosome disassembly; IBA:GO_Central.
DR   Gene3D; 3.30.110.10; Translation initiation factor 3 (IF-3), C-terminal domain; 1.
DR   Gene3D; 3.10.20.80; Translation initiation factor 3 (IF-3), N-terminal domain; 1.
DR   HAMAP; MF_00080; IF_3; 1.
DR   InterPro; IPR036788; T_IF-3_C_sf.
DR   InterPro; IPR036787; T_IF-3_N_sf.
DR   InterPro; IPR019813; Translation_initiation_fac3_CS.
DR   InterPro; IPR001288; Translation_initiation_fac_3.
DR   InterPro; IPR019815; Translation_initiation_fac_3_C.
DR   InterPro; IPR019814; Translation_initiation_fac_3_N.
DR   NCBIfam; TIGR00168; infC; 1.
DR   PANTHER; PTHR10938; TRANSLATION INITIATION FACTOR IF-3; 1.
DR   PANTHER; PTHR10938:SF0; TRANSLATION INITIATION FACTOR IF-3, MITOCHONDRIAL; 1.
DR   Pfam; PF00707; IF3_C; 1.
DR   Pfam; PF05198; IF3_N; 1.
DR   SUPFAM; SSF55200; Translation initiation factor IF3, C-terminal domain; 1.
DR   SUPFAM; SSF54364; Translation initiation factor IF3, N-terminal domain; 1.
DR   PROSITE; PS00938; IF3; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..185
FT                   /note="Translation initiation factor IF-3"
FT                   /id="PRO_0000177513"
SQ   SEQUENCE   185 AA;  21390 MW;  8D69777F8FD239EE CRC64;
     MRSKRTRVNN QIRVPEVRLI DEKGEQVGVV RTDRALTMAE EAGLDLVEIS PTAKPPVCRI
     MNFGKYQFEQ SKRKAAQKKK QRLVHLKEVK FRPGTDVGDY QVKLRKIATF LDRGDKVKVS
     LRFRGREMQH RELGLELLGR VKRDLGNIVV EQEPRLEGRQ MTMVVMKAKG EGNKTKREDH
     AEIKD
//