Q83C11 (IF3_COXBU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Translation initiation factor IF-3

Gene names

Name:	infC
Ordered Locus Names:	CBU_1325

Organism

Coxiella burnetii (strain RSA 493 / Nine Mile phase I) [Reference proteome] [HAMAP]

Taxonomic identifier

227377 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella › Coxiella burnetii

Protein attributes

Sequence length	185 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins By similarity. HAMAP-Rule MF_00080
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the IF-3 family.
Sequence caution	The sequence AAO90829.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Molecular function	Initiation factor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	translation initiation factor activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 185	185	Translation initiation factor IF-3 HAMAP-Rule MF_00080		PRO_0000177513

Sequences

	Sequence		Length	Mass (Da)
	Q83C11 [UniParc]. Last modified December 15, 2003. Version 2. Checksum: 8D69777F8FD239EE	FASTA	185	21,390
	10 20 30 40 50 60 MRSKRTRVNN QIRVPEVRLI DEKGEQVGVV RTDRALTMAE EAGLDLVEIS PTAKPPVCRI 70 80 90 100 110 120 MNFGKYQFEQ SKRKAAQKKK QRLVHLKEVK FRPGTDVGDY QVKLRKIATF LDRGDKVKVS 130 140 150 160 170 180 LRFRGREMQH RELGLELLGR VKRDLGNIVV EQEPRLEGRQ MTMVVMKAKG EGNKTKREDH AEIKD

References

[1]

"Complete genome sequence of the Q-fever pathogen, Coxiella burnetii." Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A. , Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E., Fraser C.M., Heidelberg J.F. Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RSA 493 / Nine Mile phase I.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016828 Genomic DNA. Translation: AAO90829.1. Different initiation.
RefSeq	NP_820315.1. NC_002971.3.
3D structure databases
ProteinModelPortal	Q83C11.
ModBase	Search...
Protein-protein interaction databases
STRING	227377.CBU_1325.
Proteomic databases
PRIDE	Q83C11.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAO90829; AAO90829; CBU_1325.
GeneID	1209231.
KEGG	cbu:CBU_1325.
PATRIC	17931385. VBICoxBur82552_1316.
Phylogenomic databases
eggNOG	COG0290.
HOGENOM	HOG000035157.
KO	K02520.
OMA	HDYQTKV.
ProtClustDB	PRK00028.
Enzyme and pathway databases
BioCyc	CBUR227377:GJ7S-1316-MONOMER.
Family and domain databases
Gene3D	3.10.20.80. 1 hit.
HAMAP	MF_00080. IF-3.
InterPro	IPR019813. Translation_initiation_fac3_CS. IPR001288. Translation_initiation_fac_3. IPR019815. Translation_initiation_fac_3_C. IPR019814. Translation_initiation_fac_3_N. [Graphical view]
PANTHER	PTHR10938. PTHR10938. 1 hit.
Pfam	PF00707. IF3_C. 1 hit. PF05198. IF3_N. 1 hit. [Graphical view]
SUPFAM	SSF54364. IF3. 1 hit. SSF55200. IF3. 1 hit.
TIGRFAMs	TIGR00168. infC. 1 hit.
PROSITE	PS00938. IF3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IF3_COXBU

Accession

Primary (citable) accession number: Q83C11

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 2003
Last sequence update:	December 15, 2003
Last modified:	May 1, 2013
This is version 59 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program