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Q83C10

- SYT_COXBU

UniProt

Q83C10 - SYT_COXBU

Protein

Threonine--tRNA ligase

Gene

thrS

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi333 – 3331Zinc; catalyticUniRule annotation
    Metal bindingi384 – 3841Zinc; catalyticUniRule annotation
    Metal bindingi510 – 5101Zinc; catalyticUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW
    3. threonine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. threonyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciCBUR227377:GJ7S-1317-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Threonine--tRNA ligaseUniRule annotation (EC:6.1.1.3UniRule annotation)
    Alternative name(s):
    Threonyl-tRNA synthetaseUniRule annotation
    Short name:
    ThrRSUniRule annotation
    Gene namesi
    Name:thrSUniRule annotation
    Ordered Locus Names:CBU_1326
    OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
    Taxonomic identifieri227377 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
    ProteomesiUP000002671: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 651651Threonine--tRNA ligasePRO_0000100971Add
    BLAST

    Proteomic databases

    PRIDEiQ83C10.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi227377.CBU_1326.

    Structurei

    3D structure databases

    ProteinModelPortaliQ83C10.
    SMRiQ83C10. Positions 241-637.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni242 – 533292CatalyticAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0441.
    HOGENOMiHOG000003880.
    KOiK01868.
    OMAiHFKLQKI.
    OrthoDBiEOG61KBFJ.

    Family and domain databases

    Gene3Di3.10.20.30. 1 hit.
    3.40.50.800. 1 hit.
    HAMAPiMF_00184. Thr_tRNA_synth.
    InterProiIPR002314. aa-tRNA-synt_IIb_cons-dom.
    IPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR012675. Beta-grasp_dom.
    IPR012676. TGS-like.
    IPR002320. Thr-tRNA-ligase_IIa.
    IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
    IPR012947. tRNA_SAD.
    [Graphical view]
    PfamiPF03129. HGTP_anticodon. 1 hit.
    PF00587. tRNA-synt_2b. 1 hit.
    PF07973. tRNA_SAD. 1 hit.
    [Graphical view]
    PRINTSiPR01047. TRNASYNTHTHR.
    SMARTiSM00863. tRNA_SAD. 1 hit.
    [Graphical view]
    SUPFAMiSSF52954. SSF52954. 1 hit.
    SSF55186. SSF55186. 1 hit.
    SSF81271. SSF81271. 1 hit.
    TIGRFAMsiTIGR00418. thrS. 1 hit.
    PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q83C10-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPTIQLPDGS VKQFSKPVSV QAVAESIGTS LAKPALAGKI DDHLVDVSFI    50
    IDKDVSLRII TEKDPEGLEV IRHSAAHLLA HAVKELFPKA EVTIGPVVED 100
    GFYYDFAFER SFTPEDLEKI EEKMRSLAKA DLAVERRVLS RDEALTLFKK 150
    MGERYKVEII RDIPKEEILT AYQQGDFIDL CRGPHVPRTG MLKAFKLTKL 200
    AGAYWRGDSN NEMLQRIYGT AWADTKALKA YLYRLEEAEK RDHRLLAKKM 250
    DLFHFQPESP GNVFWHPNGW SIILQMREYI RHITHKYGYQ EVHTPQLIDA 300
    SLWDKSGHLE KFGDDIFSLP LEPQQYVIKP MSCPAHVQIF NQGVKSYRDL 350
    PLRYAEFGAC HRNEPSGTLH GLMRLRGFVQ DDAHIFCTED QIQSEVSAFI 400
    DQLHEVYADF GFTEVIHKLS TRPEKRVGSD EVWTKAEQAL AEALNRKGVE 450
    WDILPGEGAF YGPKIEFSLR DCLGRIWQCG TVQVDFSVPE RLGAHYIAED 500
    GSKKPPVMIH RAILGSFERF LGILLEESAG KLPLWLAPVQ VVVMNITDRQ 550
    ADYVGQTVEN LQNLGIRAHS DLRNEKIGFK IREHTIARVP YLVVIGDREV 600
    ADKTLSVRAL EDEASTTITL EEFARQLKAE ISQRSRKSPA PSPLFPVGGE 650
    S 651
    Length:651
    Mass (Da):73,784
    Last modified:June 1, 2003 - v1
    Checksum:i8BADE57CA2D780D2
    GO

    Sequence cautioni

    The sequence AAO90830.2 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO90830.2. Different initiation.
    RefSeqiNP_820316.2. NC_002971.3.

    Genome annotation databases

    EnsemblBacteriaiAAO90830; AAO90830; CBU_1326.
    GeneIDi1209232.
    KEGGicbu:CBU_1326.
    PATRICi17931387. VBICoxBur82552_1317.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO90830.2 . Different initiation.
    RefSeqi NP_820316.2. NC_002971.3.

    3D structure databases

    ProteinModelPortali Q83C10.
    SMRi Q83C10. Positions 241-637.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 227377.CBU_1326.

    Proteomic databases

    PRIDEi Q83C10.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO90830 ; AAO90830 ; CBU_1326 .
    GeneIDi 1209232.
    KEGGi cbu:CBU_1326.
    PATRICi 17931387. VBICoxBur82552_1317.

    Phylogenomic databases

    eggNOGi COG0441.
    HOGENOMi HOG000003880.
    KOi K01868.
    OMAi HFKLQKI.
    OrthoDBi EOG61KBFJ.

    Enzyme and pathway databases

    BioCyci CBUR227377:GJ7S-1317-MONOMER.

    Family and domain databases

    Gene3Di 3.10.20.30. 1 hit.
    3.40.50.800. 1 hit.
    HAMAPi MF_00184. Thr_tRNA_synth.
    InterProi IPR002314. aa-tRNA-synt_IIb_cons-dom.
    IPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR012675. Beta-grasp_dom.
    IPR012676. TGS-like.
    IPR002320. Thr-tRNA-ligase_IIa.
    IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
    IPR012947. tRNA_SAD.
    [Graphical view ]
    Pfami PF03129. HGTP_anticodon. 1 hit.
    PF00587. tRNA-synt_2b. 1 hit.
    PF07973. tRNA_SAD. 1 hit.
    [Graphical view ]
    PRINTSi PR01047. TRNASYNTHTHR.
    SMARTi SM00863. tRNA_SAD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52954. SSF52954. 1 hit.
    SSF55186. SSF55186. 1 hit.
    SSF81271. SSF81271. 1 hit.
    TIGRFAMsi TIGR00418. thrS. 1 hit.
    PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RSA 493 / Nine Mile phase I.

    Entry informationi

    Entry nameiSYT_COXBU
    AccessioniPrimary (citable) accession number: Q83C10
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. Coxiella burnetii
      Coxiella burnetii (strain RSA 493): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3