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Q83C10

- SYT_COXBU

UniProt

Q83C10 - SYT_COXBU

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Protein

Threonine--tRNA ligase

Gene

thrS

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).UniRule annotation

Cofactori

Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi333 – 3331Zinc; catalyticUniRule annotation
Metal bindingi384 – 3841Zinc; catalyticUniRule annotation
Metal bindingi510 – 5101Zinc; catalyticUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW
  3. threonine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. threonyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-1317-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine--tRNA ligaseUniRule annotation (EC:6.1.1.3UniRule annotation)
Alternative name(s):
Threonyl-tRNA synthetaseUniRule annotation
Short name:
ThrRSUniRule annotation
Gene namesi
Name:thrSUniRule annotation
Ordered Locus Names:CBU_1326
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 651651Threonine--tRNA ligasePRO_0000100971Add
BLAST

Proteomic databases

PRIDEiQ83C10.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi227377.CBU_1326.

Structurei

3D structure databases

ProteinModelPortaliQ83C10.
SMRiQ83C10. Positions 241-637.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni242 – 533292CatalyticAdd
BLAST

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0441.
HOGENOMiHOG000003880.
KOiK01868.
OMAiHFKLQKI.
OrthoDBiEOG61KBFJ.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
3.40.50.800. 1 hit.
HAMAPiMF_00184. Thr_tRNA_synth.
InterProiIPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR012675. Beta-grasp_dom.
IPR012676. TGS-like.
IPR002320. Thr-tRNA-ligase_IIa.
IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
IPR012947. tRNA_SAD.
[Graphical view]
PfamiPF03129. HGTP_anticodon. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
PF07973. tRNA_SAD. 1 hit.
[Graphical view]
PRINTSiPR01047. TRNASYNTHTHR.
SMARTiSM00863. tRNA_SAD. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.
SSF55186. SSF55186. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00418. thrS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q83C10-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPTIQLPDGS VKQFSKPVSV QAVAESIGTS LAKPALAGKI DDHLVDVSFI
60 70 80 90 100
IDKDVSLRII TEKDPEGLEV IRHSAAHLLA HAVKELFPKA EVTIGPVVED
110 120 130 140 150
GFYYDFAFER SFTPEDLEKI EEKMRSLAKA DLAVERRVLS RDEALTLFKK
160 170 180 190 200
MGERYKVEII RDIPKEEILT AYQQGDFIDL CRGPHVPRTG MLKAFKLTKL
210 220 230 240 250
AGAYWRGDSN NEMLQRIYGT AWADTKALKA YLYRLEEAEK RDHRLLAKKM
260 270 280 290 300
DLFHFQPESP GNVFWHPNGW SIILQMREYI RHITHKYGYQ EVHTPQLIDA
310 320 330 340 350
SLWDKSGHLE KFGDDIFSLP LEPQQYVIKP MSCPAHVQIF NQGVKSYRDL
360 370 380 390 400
PLRYAEFGAC HRNEPSGTLH GLMRLRGFVQ DDAHIFCTED QIQSEVSAFI
410 420 430 440 450
DQLHEVYADF GFTEVIHKLS TRPEKRVGSD EVWTKAEQAL AEALNRKGVE
460 470 480 490 500
WDILPGEGAF YGPKIEFSLR DCLGRIWQCG TVQVDFSVPE RLGAHYIAED
510 520 530 540 550
GSKKPPVMIH RAILGSFERF LGILLEESAG KLPLWLAPVQ VVVMNITDRQ
560 570 580 590 600
ADYVGQTVEN LQNLGIRAHS DLRNEKIGFK IREHTIARVP YLVVIGDREV
610 620 630 640 650
ADKTLSVRAL EDEASTTITL EEFARQLKAE ISQRSRKSPA PSPLFPVGGE

S
Length:651
Mass (Da):73,784
Last modified:June 1, 2003 - v1
Checksum:i8BADE57CA2D780D2
GO

Sequence cautioni

The sequence AAO90830.2 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016828 Genomic DNA. Translation: AAO90830.2. Different initiation.
RefSeqiNP_820316.2. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO90830; AAO90830; CBU_1326.
GeneIDi1209232.
KEGGicbu:CBU_1326.
PATRICi17931387. VBICoxBur82552_1317.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016828 Genomic DNA. Translation: AAO90830.2 . Different initiation.
RefSeqi NP_820316.2. NC_002971.3.

3D structure databases

ProteinModelPortali Q83C10.
SMRi Q83C10. Positions 241-637.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227377.CBU_1326.

Proteomic databases

PRIDEi Q83C10.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO90830 ; AAO90830 ; CBU_1326 .
GeneIDi 1209232.
KEGGi cbu:CBU_1326.
PATRICi 17931387. VBICoxBur82552_1317.

Phylogenomic databases

eggNOGi COG0441.
HOGENOMi HOG000003880.
KOi K01868.
OMAi HFKLQKI.
OrthoDBi EOG61KBFJ.

Enzyme and pathway databases

BioCyci CBUR227377:GJ7S-1317-MONOMER.

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
3.40.50.800. 1 hit.
HAMAPi MF_00184. Thr_tRNA_synth.
InterProi IPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR012675. Beta-grasp_dom.
IPR012676. TGS-like.
IPR002320. Thr-tRNA-ligase_IIa.
IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
IPR012947. tRNA_SAD.
[Graphical view ]
Pfami PF03129. HGTP_anticodon. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
PF07973. tRNA_SAD. 1 hit.
[Graphical view ]
PRINTSi PR01047. TRNASYNTHTHR.
SMARTi SM00863. tRNA_SAD. 1 hit.
[Graphical view ]
SUPFAMi SSF52954. SSF52954. 1 hit.
SSF55186. SSF55186. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsi TIGR00418. thrS. 1 hit.
PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiSYT_COXBU
AccessioniPrimary (citable) accession number: Q83C10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3