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Q83BY4

- RLME_COXBU

UniProt

Q83BY4 - RLME_COXBU

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Protein
Ribosomal RNA large subunit methyltransferase E
Gene
rlmE, ftsJ, rrmJ, CBU_1353
Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + uridine(2552) in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methyluridine(2552) in 23S rRNA.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei57 – 571S-adenosyl-L-methionine; via amide nitrogen By similarity
Binding sitei59 – 591S-adenosyl-L-methionine; via amide nitrogen By similarity
Binding sitei77 – 771S-adenosyl-L-methionine By similarity
Binding sitei93 – 931S-adenosyl-L-methionine By similarity
Binding sitei122 – 1221S-adenosyl-L-methionine By similarity
Active sitei162 – 1621Proton acceptor By similarity

GO - Molecular functioni

  1. rRNA (uridine-2'-O-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-1343-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA large subunit methyltransferase E (EC:2.1.1.166)
Alternative name(s):
23S rRNA Um2552 methyltransferase
rRNA (uridine-2'-O-)-methyltransferase
Gene namesi
Name:rlmE
Synonyms:ftsJ, rrmJ
Ordered Locus Names:CBU_1353
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Ribosomal RNA large subunit methyltransferase EUniRule annotation
PRO_0000155489Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi227377.CBU_1353.

Structurei

3D structure databases

ProteinModelPortaliQ83BY4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0293.
HOGENOMiHOG000162366.
KOiK02427.
OMAiQYVVSQI.
OrthoDBiEOG657JC0.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01547. RNA_methyltr_E.
InterProiIPR015507. rRNA-MeTfrase_E.
IPR002877. rRNA_MeTrfase_FtsJ_dom.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERiPTHR10920. PTHR10920. 1 hit.
PfamiPF01728. FtsJ. 1 hit.
[Graphical view]
PIRSFiPIRSF005461. 23S_rRNA_mtase. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

Q83BY4-1 [UniParc]FASTAAdd to Basket

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MTHSKRWLEE HEKDPYVKRA KKEGYPSRAA YKLLEIHQKY KLFKPSMNVI    50
DLGAAPGGWS QVAKDLVGPK GVVIAIDLLP MQSMLDVIFI QGDFNEPEIF 100
NQLEAIVAKK TLTGQVDLVI SDMAPNISGI KNVDQSRSLH LVELAWDCAQ 150
KLLARGGTFL VKVFQGPGVD RFLINLRPYF NQVKFLKPSA SRSRSSEIYI 200
LAGEFLGYNQ RV 212
Length:212
Mass (Da):23,862
Last modified:June 1, 2003 - v1
Checksum:iD5E1DD704C8FE8B7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016828 Genomic DNA. Translation: AAO90856.1.
RefSeqiNP_820342.1. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO90856; AAO90856; CBU_1353.
GeneIDi1209259.
KEGGicbu:CBU_1353.
PATRICi17931449. VBICoxBur82552_1348.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016828 Genomic DNA. Translation: AAO90856.1 .
RefSeqi NP_820342.1. NC_002971.3.

3D structure databases

ProteinModelPortali Q83BY4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227377.CBU_1353.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO90856 ; AAO90856 ; CBU_1353 .
GeneIDi 1209259.
KEGGi cbu:CBU_1353.
PATRICi 17931449. VBICoxBur82552_1348.

Phylogenomic databases

eggNOGi COG0293.
HOGENOMi HOG000162366.
KOi K02427.
OMAi QYVVSQI.
OrthoDBi EOG657JC0.

Enzyme and pathway databases

BioCyci CBUR227377:GJ7S-1343-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01547. RNA_methyltr_E.
InterProi IPR015507. rRNA-MeTfrase_E.
IPR002877. rRNA_MeTrfase_FtsJ_dom.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PANTHERi PTHR10920. PTHR10920. 1 hit.
Pfami PF01728. FtsJ. 1 hit.
[Graphical view ]
PIRSFi PIRSF005461. 23S_rRNA_mtase. 1 hit.
SUPFAMi SSF53335. SSF53335. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiRLME_COXBU
AccessioniPrimary (citable) accession number: Q83BY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2003
Last modified: June 11, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi