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Q83BY4

- RLME_COXBU

UniProt

Q83BY4 - RLME_COXBU

Protein

Ribosomal RNA large subunit methyltransferase E

Gene

rlmE

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + uridine(2552) in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methyluridine(2552) in 23S rRNA.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei57 – 571S-adenosyl-L-methionine; via amide nitrogenUniRule annotation
    Binding sitei59 – 591S-adenosyl-L-methionine; via amide nitrogenUniRule annotation
    Binding sitei77 – 771S-adenosyl-L-methionineUniRule annotation
    Binding sitei93 – 931S-adenosyl-L-methionineUniRule annotation
    Binding sitei122 – 1221S-adenosyl-L-methionineUniRule annotation
    Active sitei162 – 1621Proton acceptorUniRule annotation

    GO - Molecular functioni

    1. rRNA (uridine-2'-O-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    rRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciCBUR227377:GJ7S-1343-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribosomal RNA large subunit methyltransferase EUniRule annotation (EC:2.1.1.166UniRule annotation)
    Alternative name(s):
    23S rRNA Um2552 methyltransferaseUniRule annotation
    rRNA (uridine-2'-O-)-methyltransferaseUniRule annotation
    Gene namesi
    Name:rlmEUniRule annotation
    Synonyms:ftsJUniRule annotation, rrmJUniRule annotation
    Ordered Locus Names:CBU_1353
    OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
    Taxonomic identifieri227377 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
    ProteomesiUP000002671: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 212212Ribosomal RNA large subunit methyltransferase EPRO_0000155489Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi227377.CBU_1353.

    Structurei

    3D structure databases

    ProteinModelPortaliQ83BY4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the methyltransferase superfamily. RlmE family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0293.
    HOGENOMiHOG000162366.
    KOiK02427.
    OMAiQYVVSQI.
    OrthoDBiEOG657JC0.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01547. RNA_methyltr_E.
    InterProiIPR015507. rRNA-MeTfrase_E.
    IPR002877. rRNA_MeTrfase_FtsJ_dom.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PANTHERiPTHR10920. PTHR10920. 1 hit.
    PfamiPF01728. FtsJ. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005461. 23S_rRNA_mtase. 1 hit.
    SUPFAMiSSF53335. SSF53335. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q83BY4-1 [UniParc]FASTAAdd to Basket

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    MTHSKRWLEE HEKDPYVKRA KKEGYPSRAA YKLLEIHQKY KLFKPSMNVI    50
    DLGAAPGGWS QVAKDLVGPK GVVIAIDLLP MQSMLDVIFI QGDFNEPEIF 100
    NQLEAIVAKK TLTGQVDLVI SDMAPNISGI KNVDQSRSLH LVELAWDCAQ 150
    KLLARGGTFL VKVFQGPGVD RFLINLRPYF NQVKFLKPSA SRSRSSEIYI 200
    LAGEFLGYNQ RV 212
    Length:212
    Mass (Da):23,862
    Last modified:June 1, 2003 - v1
    Checksum:iD5E1DD704C8FE8B7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO90856.1.
    RefSeqiNP_820342.1. NC_002971.3.

    Genome annotation databases

    EnsemblBacteriaiAAO90856; AAO90856; CBU_1353.
    GeneIDi1209259.
    KEGGicbu:CBU_1353.
    PATRICi17931449. VBICoxBur82552_1348.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO90856.1 .
    RefSeqi NP_820342.1. NC_002971.3.

    3D structure databases

    ProteinModelPortali Q83BY4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 227377.CBU_1353.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO90856 ; AAO90856 ; CBU_1353 .
    GeneIDi 1209259.
    KEGGi cbu:CBU_1353.
    PATRICi 17931449. VBICoxBur82552_1348.

    Phylogenomic databases

    eggNOGi COG0293.
    HOGENOMi HOG000162366.
    KOi K02427.
    OMAi QYVVSQI.
    OrthoDBi EOG657JC0.

    Enzyme and pathway databases

    BioCyci CBUR227377:GJ7S-1343-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01547. RNA_methyltr_E.
    InterProi IPR015507. rRNA-MeTfrase_E.
    IPR002877. rRNA_MeTrfase_FtsJ_dom.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PANTHERi PTHR10920. PTHR10920. 1 hit.
    Pfami PF01728. FtsJ. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005461. 23S_rRNA_mtase. 1 hit.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RSA 493 / Nine Mile phase I.

    Entry informationi

    Entry nameiRLME_COXBU
    AccessioniPrimary (citable) accession number: Q83BY4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Coxiella burnetii
      Coxiella burnetii (strain RSA 493): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3