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Protein

Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)

Gene

uppS

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.UniRule annotation

Catalytic activityi

(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate = 8 diphosphate + di-trans,octa-cis-undecaprenyl diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei11UniRule annotation1
Metal bindingi11MagnesiumUniRule annotation1
Binding sitei16SubstrateUniRule annotation1
Binding sitei24SubstrateUniRule annotation1
Binding sitei28SubstrateUniRule annotation1
Active sitei59Proton acceptorUniRule annotation1
Binding sitei62SubstrateUniRule annotation1
Binding sitei179SubstrateUniRule annotation1
Metal bindingi198MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)UniRule annotation (EC:2.5.1.31UniRule annotation)
Alternative name(s):
Ditrans,polycis-undecaprenylcistransferaseUniRule annotation
Undecaprenyl diphosphate synthaseUniRule annotation
Short name:
UDSUniRule annotation
Undecaprenyl pyrophosphate synthaseUniRule annotation
Short name:
UPP synthaseUniRule annotation
Gene namesi
Name:uppSUniRule annotation
Ordered Locus Names:CBU_1382
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
Proteomesi
  • UP000002671 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001236071 – 237Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)Add BLAST237

Proteomic databases

PRIDEiQ83BV5.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi227377.CBU_1382.

Structurei

3D structure databases

ProteinModelPortaliQ83BV5.
SMRiQ83BV5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni12 – 15Substrate bindingUniRule annotation4
Regioni56 – 58Substrate bindingUniRule annotation3
Regioni185 – 187Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the UPP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CR3. Bacteria.
COG0020. LUCA.
HOGENOMiHOG000006054.
KOiK00806.
OMAiFDRRDLW.

Family and domain databases

CDDicd00475. Cis_IPPS. 1 hit.
Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT. 1 hit.
InterProiView protein in InterPro
IPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
IPR036424. UPP_synth-like_sf.
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiView protein in Pfam
PF01255. Prenyltransf. 1 hit.
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiView protein in PROSITE
PS01066. UPP_SYNTHASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q83BV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPRHVAIVM DGNGRWANRR GLPRVAGHRA GAKVVRRIVE YAAEKPLEVL
60 70 80 90 100
TLFAFSIENR ARPQSEVNFL MSLFLDSLKK NTEELHKNNV QLRVIGDHRE
110 120 130 140 150
FDKKMLAQIQ TSQDLTKHNT GLKLIIALNY SGRWDILQAV QRMAEKIKNQ
160 170 180 190 200
ELTSELMSAE LFQNYLCLSD LPEPDLLIRT SGEQRLSNFM LWQFAYTEIY
210 220 230
FTPALWPDFN EETFDQALAF YRTRQRRFGL TPEQVEK
Length:237
Mass (Da):27,630
Last modified:June 1, 2003 - v1
Checksum:i689DEDD700E7AD85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO90885.1.
RefSeqiNP_820371.1. NC_002971.3.
WP_005771680.1. NZ_CDBG01000001.1.

Genome annotation databases

EnsemblBacteriaiAAO90885; AAO90885; CBU_1382.
GeneIDi1209288.
31483247.
KEGGicbu:CBU_1382.
PATRICifig|227377.7.peg.1378.

Similar proteinsi

Entry informationi

Entry nameiUPPS_COXBU
AccessioniPrimary (citable) accession number: Q83BV5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: June 1, 2003
Last modified: October 25, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families