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Q83BS1 (IF2_COXBU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Translation initiation factor IF-2
Gene names
Name:infB
Ordered Locus Names:CBU_1432
OrganismCoxiella burnetii (strain RSA 493 / Nine Mile phase I) [Reference proteome] [HAMAP]
Taxonomic identifier227377 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella

Protein attributes

Sequence length803 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity. HAMAP-Rule MF_00100

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00100.

Sequence similarities

Belongs to the IF-2 family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandGTP-binding
Nucleotide-binding
   Molecular functionInitiation factor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

GTPase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

translation initiation factor activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 803803Translation initiation factor IF-2 HAMAP-Rule MF_00100
PRO_0000137198

Regions

Nucleotide binding311 – 3188GTP By similarity
Nucleotide binding357 – 3615GTP By similarity
Nucleotide binding411 – 4144GTP By similarity
Region305 – 453149G-domain HAMAP-Rule MF_00100

Sequences

Sequence LengthMass (Da)Tools
Q83BS1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 00C73115E6B3D5C9

FASTA80388,486
        10         20         30         40         50         60 
MADMSVKQLA DLVRTTPERL LEQLKEAGVA ITHVDQTISD EEKRKLLLHL KTSHSTETDK 

        70         80         90        100        110        120 
KRSKIVLKRK KLSVVKSGKK SVNVEIRSKR TYTKPVVEQK RETEPAPTQE VPPTSDTTNL 

       130        140        150        160        170        180 
NEKAEVNVAT LEKAVEAEVK EEAKKTPSEK KETPKKGPRK ETRRSRKPDK EDKWEREELH 

       190        200        210        220        230        240 
MTKLVEERRR RHKPAHMPDS DSASAKLEQG FARPTAPVVR EVALPESITV ADLAQKMSVK 

       250        260        270        280        290        300 
AAEVIKAMMK LGAMVTINQR IDQETAAIVV EEMGHKPKLI KEDVLEENLV ATLGEQTGEA 

       310        320        330        340        350        360 
VPRAPVVTIM GHVDHGKTSL LDYIRRTKVT STEAGGITQH IGAYHVETEL GMITFLDTPG 

       370        380        390        400        410        420 
HEAFTAMRAR GAKCTDIVVL VVAADDGVMP QTVEAIQHAR AAKVPVVVAV NKIDKPEADP 

       430        440        450        460        470        480 
ERIKTELSTH DVLPEEWGGD TMFQPISAKT GEGIDALLER ILLQAEVLEL KAVDNGPARG 

       490        500        510        520        530        540 
MVVESRLDRG RGPVATVLVT SGELHLGDIL LVGREYGRVR AMIGDDGRPC ESAGPSMPVE 

       550        560        570        580        590        600 
VLGLSGTSVA GEEAIVVPDE RKAREIARFR QGKYREVRLA KKQTAHLERI FDRMGEGKQN 

       610        620        630        640        650        660 
TLNIVLKADV QGSLEALTEA LNKLSTDEVK VNIIASGVGG ITESDVNLAI ASDAVVIGFN 

       670        680        690        700        710        720 
VRADAPTRVL VEREGVDLRY YSIIYDLIDE VKKALSGLLA PEFEEKIVGL AEVRDVFRSS 

       730        740        750        760        770        780 
KIGAIAGCMV VEGVVRRHLP IRVLRDNVVI YEGQLESLRR YKEDVAEVRQ GTECGIGVKN 

       790        800 
YNDVKVGDQI EVYEKTQVHR TIA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016828 Genomic DNA. Translation: AAO90929.1.
RefSeqNP_820415.1. NC_002971.3.

3D structure databases

ProteinModelPortalQ83BS1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING227377.CBU_1432.

Proteomic databases

PRIDEQ83BS1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO90929; AAO90929; CBU_1432.
GeneID1209338.
KEGGcbu:CBU_1432.
PATRIC17931615. VBICoxBur82552_1431.

Phylogenomic databases

eggNOGCOG0532.
HOGENOMHOG000076907.
KOK02519.
OMAQLFDIHL.
OrthoDBEOG67HJSV.
ProtClustDBPRK05306.

Enzyme and pathway databases

BioCycCBUR227377:GJ7S-1419-MONOMER.

Family and domain databases

Gene3D3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_00100_B. IF_2_B.
InterProIPR009061. DNA-bd_dom_put.
IPR000795. EF_GTP-bd_dom.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
SUPFAMSSF46955. SSF46955. 1 hit.
SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEPS01176. IF2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIF2_COXBU
AccessionPrimary (citable) accession number: Q83BS1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Translation initiation factors

List of translation initiation factor entries

Coxiella burnetii

Coxiella burnetii (strain RSA 493): entries and gene names