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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi311 – 318GTPUniRule annotation8
Nucleotide bindingi357 – 361GTPUniRule annotation5
Nucleotide bindingi411 – 414GTPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:CBU_1432
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
Proteomesi
  • UP000002671 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001371981 – 803Translation initiation factor IF-2Add BLAST803

Proteomic databases

PRIDEiQ83BS1.

Interactioni

Protein-protein interaction databases

STRINGi227377.CBU_1432.

Structurei

3D structure databases

ProteinModelPortaliQ83BS1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini302 – 471tr-type GAdd BLAST170

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni311 – 318G1By similarity8
Regioni336 – 340G2By similarity5
Regioni357 – 360G3By similarity4
Regioni411 – 414G4By similarity4
Regioni447 – 449G5By similarity3

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QHU. Bacteria.
COG0532. LUCA.
HOGENOMiHOG000076907.
KOiK02519.
OMAiYISVNKL.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B. 1 hit.
InterProiIPR009061. DNA-bd_dom_put.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q83BS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADMSVKQLA DLVRTTPERL LEQLKEAGVA ITHVDQTISD EEKRKLLLHL
60 70 80 90 100
KTSHSTETDK KRSKIVLKRK KLSVVKSGKK SVNVEIRSKR TYTKPVVEQK
110 120 130 140 150
RETEPAPTQE VPPTSDTTNL NEKAEVNVAT LEKAVEAEVK EEAKKTPSEK
160 170 180 190 200
KETPKKGPRK ETRRSRKPDK EDKWEREELH MTKLVEERRR RHKPAHMPDS
210 220 230 240 250
DSASAKLEQG FARPTAPVVR EVALPESITV ADLAQKMSVK AAEVIKAMMK
260 270 280 290 300
LGAMVTINQR IDQETAAIVV EEMGHKPKLI KEDVLEENLV ATLGEQTGEA
310 320 330 340 350
VPRAPVVTIM GHVDHGKTSL LDYIRRTKVT STEAGGITQH IGAYHVETEL
360 370 380 390 400
GMITFLDTPG HEAFTAMRAR GAKCTDIVVL VVAADDGVMP QTVEAIQHAR
410 420 430 440 450
AAKVPVVVAV NKIDKPEADP ERIKTELSTH DVLPEEWGGD TMFQPISAKT
460 470 480 490 500
GEGIDALLER ILLQAEVLEL KAVDNGPARG MVVESRLDRG RGPVATVLVT
510 520 530 540 550
SGELHLGDIL LVGREYGRVR AMIGDDGRPC ESAGPSMPVE VLGLSGTSVA
560 570 580 590 600
GEEAIVVPDE RKAREIARFR QGKYREVRLA KKQTAHLERI FDRMGEGKQN
610 620 630 640 650
TLNIVLKADV QGSLEALTEA LNKLSTDEVK VNIIASGVGG ITESDVNLAI
660 670 680 690 700
ASDAVVIGFN VRADAPTRVL VEREGVDLRY YSIIYDLIDE VKKALSGLLA
710 720 730 740 750
PEFEEKIVGL AEVRDVFRSS KIGAIAGCMV VEGVVRRHLP IRVLRDNVVI
760 770 780 790 800
YEGQLESLRR YKEDVAEVRQ GTECGIGVKN YNDVKVGDQI EVYEKTQVHR

TIA
Length:803
Mass (Da):88,486
Last modified:June 1, 2003 - v1
Checksum:i00C73115E6B3D5C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO90929.1.
RefSeqiNP_820415.1. NC_002971.3.
WP_010958223.1. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO90929; AAO90929; CBU_1432.
GeneIDi1209338.
KEGGicbu:CBU_1432.
PATRICi17931615. VBICoxBur82552_1431.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO90929.1.
RefSeqiNP_820415.1. NC_002971.3.
WP_010958223.1. NC_002971.3.

3D structure databases

ProteinModelPortaliQ83BS1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi227377.CBU_1432.

Proteomic databases

PRIDEiQ83BS1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO90929; AAO90929; CBU_1432.
GeneIDi1209338.
KEGGicbu:CBU_1432.
PATRICi17931615. VBICoxBur82552_1431.

Phylogenomic databases

eggNOGiENOG4107QHU. Bacteria.
COG0532. LUCA.
HOGENOMiHOG000076907.
KOiK02519.
OMAiYISVNKL.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B. 1 hit.
InterProiIPR009061. DNA-bd_dom_put.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIF2_COXBU
AccessioniPrimary (citable) accession number: Q83BS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.