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Q83BS1

- IF2_COXBU

UniProt

Q83BS1 - IF2_COXBU

Protein

Translation initiation factor IF-2

Gene

infB

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi311 – 3188GTPUniRule annotation
    Nucleotide bindingi357 – 3615GTPUniRule annotation
    Nucleotide bindingi411 – 4144GTPUniRule annotation

    GO - Molecular functioni

    1. GTPase activity Source: UniProtKB-HAMAP
    2. GTP binding Source: UniProtKB-KW
    3. translation initiation factor activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCBUR227377:GJ7S-1419-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translation initiation factor IF-2UniRule annotation
    Gene namesi
    Name:infBUniRule annotation
    Ordered Locus Names:CBU_1432
    OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
    Taxonomic identifieri227377 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
    ProteomesiUP000002671: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 803803Translation initiation factor IF-2PRO_0000137198Add
    BLAST

    Proteomic databases

    PRIDEiQ83BS1.

    Interactioni

    Protein-protein interaction databases

    STRINGi227377.CBU_1432.

    Structurei

    3D structure databases

    ProteinModelPortaliQ83BS1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini302 – 471170tr-type GAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni311 – 3188G1By similarity
    Regioni336 – 3405G2By similarity
    Regioni357 – 3604G3By similarity
    Regioni411 – 4144G4By similarity
    Regioni447 – 4493G5By similarity

    Sequence similaritiesi

    Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0532.
    HOGENOMiHOG000076907.
    KOiK02519.
    OMAiSTILCFN.
    OrthoDBiEOG67HJSV.

    Family and domain databases

    Gene3Di3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00100_B. IF_2_B.
    InterProiIPR009061. DNA-bd_dom_put.
    IPR000795. EF_GTP-bd_dom.
    IPR013575. IF2_assoc_dom_bac.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view]
    PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF11987. IF-2. 1 hit.
    PF08364. IF2_assoc. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view]
    SUPFAMiSSF46955. SSF46955. 1 hit.
    SSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q83BS1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADMSVKQLA DLVRTTPERL LEQLKEAGVA ITHVDQTISD EEKRKLLLHL    50
    KTSHSTETDK KRSKIVLKRK KLSVVKSGKK SVNVEIRSKR TYTKPVVEQK 100
    RETEPAPTQE VPPTSDTTNL NEKAEVNVAT LEKAVEAEVK EEAKKTPSEK 150
    KETPKKGPRK ETRRSRKPDK EDKWEREELH MTKLVEERRR RHKPAHMPDS 200
    DSASAKLEQG FARPTAPVVR EVALPESITV ADLAQKMSVK AAEVIKAMMK 250
    LGAMVTINQR IDQETAAIVV EEMGHKPKLI KEDVLEENLV ATLGEQTGEA 300
    VPRAPVVTIM GHVDHGKTSL LDYIRRTKVT STEAGGITQH IGAYHVETEL 350
    GMITFLDTPG HEAFTAMRAR GAKCTDIVVL VVAADDGVMP QTVEAIQHAR 400
    AAKVPVVVAV NKIDKPEADP ERIKTELSTH DVLPEEWGGD TMFQPISAKT 450
    GEGIDALLER ILLQAEVLEL KAVDNGPARG MVVESRLDRG RGPVATVLVT 500
    SGELHLGDIL LVGREYGRVR AMIGDDGRPC ESAGPSMPVE VLGLSGTSVA 550
    GEEAIVVPDE RKAREIARFR QGKYREVRLA KKQTAHLERI FDRMGEGKQN 600
    TLNIVLKADV QGSLEALTEA LNKLSTDEVK VNIIASGVGG ITESDVNLAI 650
    ASDAVVIGFN VRADAPTRVL VEREGVDLRY YSIIYDLIDE VKKALSGLLA 700
    PEFEEKIVGL AEVRDVFRSS KIGAIAGCMV VEGVVRRHLP IRVLRDNVVI 750
    YEGQLESLRR YKEDVAEVRQ GTECGIGVKN YNDVKVGDQI EVYEKTQVHR 800
    TIA 803
    Length:803
    Mass (Da):88,486
    Last modified:June 1, 2003 - v1
    Checksum:i00C73115E6B3D5C9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO90929.1.
    RefSeqiNP_820415.1. NC_002971.3.

    Genome annotation databases

    EnsemblBacteriaiAAO90929; AAO90929; CBU_1432.
    GeneIDi1209338.
    KEGGicbu:CBU_1432.
    PATRICi17931615. VBICoxBur82552_1431.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO90929.1 .
    RefSeqi NP_820415.1. NC_002971.3.

    3D structure databases

    ProteinModelPortali Q83BS1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 227377.CBU_1432.

    Proteomic databases

    PRIDEi Q83BS1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO90929 ; AAO90929 ; CBU_1432 .
    GeneIDi 1209338.
    KEGGi cbu:CBU_1432.
    PATRICi 17931615. VBICoxBur82552_1431.

    Phylogenomic databases

    eggNOGi COG0532.
    HOGENOMi HOG000076907.
    KOi K02519.
    OMAi STILCFN.
    OrthoDBi EOG67HJSV.

    Enzyme and pathway databases

    BioCyci CBUR227377:GJ7S-1419-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00100_B. IF_2_B.
    InterProi IPR009061. DNA-bd_dom_put.
    IPR000795. EF_GTP-bd_dom.
    IPR013575. IF2_assoc_dom_bac.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view ]
    PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF11987. IF-2. 1 hit.
    PF08364. IF2_assoc. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view ]
    SUPFAMi SSF46955. SSF46955. 1 hit.
    SSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RSA 493 / Nine Mile phase I.

    Entry informationi

    Entry nameiIF2_COXBU
    AccessioniPrimary (citable) accession number: Q83BS1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Coxiella burnetii
      Coxiella burnetii (strain RSA 493): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3