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Protein

NADH-quinone oxidoreductase subunit D

Gene

nuoD

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

Catalytic activityi

NADH + a quinone = NAD+ + a quinol.UniRule annotation

GO - Molecular functioni

  • NAD binding Source: InterPro
  • NADH dehydrogenase (ubiquinone) activity Source: TIGR
  • quinone binding Source: UniProtKB-KW

GO - Biological processi

  • mitochondrial electron transport, NADH to ubiquinone Source: TIGR

Keywordsi

Molecular functionOxidoreductase
Biological processTransport
LigandNAD, Ubiquinone

Enzyme and pathway databases

BioCyciCBUR227377:G1G0B-1431-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit DUniRule annotation (EC:1.6.5.11UniRule annotation)
Alternative name(s):
NADH dehydrogenase I subunit DUniRule annotation
NDH-1 subunit DUniRule annotation
Gene namesi
Name:nuoDUniRule annotation
Ordered Locus Names:CBU_1445
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
Proteomesi
  • UP000002671 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003718531 – 417NADH-quinone oxidoreductase subunit DAdd BLAST417

Keywords - PTMi

Quinone

Proteomic databases

PRIDEiQ83BQ8

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.UniRule annotation

Protein-protein interaction databases

STRINGi227377.CBU_1445

Structurei

3D structure databases

ProteinModelPortaliQ83BQ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 49 kDa subunit family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CQV Bacteria
COG0649 LUCA
HOGENOMiHOG000228264
KOiK00333
OMAiKKIAWPA

Family and domain databases

Gene3Di1.10.645.20, 1 hit
HAMAPiMF_01358 NDH1_NuoD, 1 hit
InterProiView protein in InterPro
IPR001135 NADH_Q_OxRdtase_suD
IPR038290 NADH_Q_OxRdtase_suD_sf
IPR014029 NADH_UbQ_OxRdtase_49kDa_CS
IPR022885 NDH1_su_D/H
IPR029014 NiFe-Hase_large
PfamiView protein in Pfam
PF00346 Complex1_49kDa, 1 hit
SUPFAMiSSF56762 SSF56762, 1 hit
TIGRFAMsiTIGR01962 NuoD, 1 hit
PROSITEiView protein in PROSITE
PS00535 COMPLEX1_49K, 1 hit

Sequencei

Sequence statusi: Complete.

Q83BQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEVRNYTFN FGPQHPAAHG VLRLIVEVDG EVIQRIDPHI GLLHRATEKL
60 70 80 90 100
AESKPYNQTI GYMDRLDYVS MMANEHGYVL AIEKLLGIEP PIRAKYIRTM
110 120 130 140 150
FDEITRILNH LLWLGAHALD VGAMTVFLYC FREREDLMDC YEAVSGARMH
160 170 180 190 200
ATYYRPGGVY RDLPDSMPKY KPSRWHNEKA VKKMNEAREG SLLDFIWDFT
210 220 230 240 250
ARFPNLIDEY ESLLTDNRIW KQRTVGIGVV SAERALQLGF TGPMLRASGV
260 270 280 290 300
EWDLRKKQPY AAYDRVDFDI PIGREGDCYD RYLVRIEEMR QSNRIIRQCV
310 320 330 340 350
EWLRKNPGSV MIDDYKIVPP QREVMKRDME ALIHHFKLFT EGYIVPEGEA
360 370 380 390 400
YAAVEQPKGE FGVYIVSDGA NKPYRVKVRA ASYPHLAAMN EMCRGHMIAD
410
LVAIISSIDI VFGEIDR
Length:417
Mass (Da):48,119
Last modified:June 1, 2003 - v1
Checksum:iC917583FA3EAE98E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA Translation: AAO90942.1
RefSeqiNP_820428.1, NC_002971.3

Genome annotation databases

EnsemblBacteriaiAAO90942; AAO90942; CBU_1445
GeneIDi1209352
KEGGicbu:CBU_1445
PATRICifig|227377.7.peg.1445

Similar proteinsi

Entry informationi

Entry nameiNUOD_COXBU
AccessioniPrimary (citable) accession number: Q83BQ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: June 1, 2003
Last modified: April 25, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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