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Q83BQ8 (NUOD_COXBU) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-quinone oxidoreductase subunit D

EC=1.6.99.5
Alternative name(s):
NADH dehydrogenase I subunit D
NDH-1 subunit D
Gene names
Name:nuoD
Ordered Locus Names:CBU_1445
OrganismCoxiella burnetii (strain RSA 493 / Nine Mile phase I) [Reference proteome] [HAMAP]
Taxonomic identifier227377 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella

Protein attributes

Sequence length417 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity. HAMAP-Rule MF_01358

Catalytic activity

NADH + quinone = NAD+ + quinol. HAMAP-Rule MF_01358

Subunit structure

NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex By similarity.

Subcellular location

Cell inner membrane; Peripheral membrane protein; Cytoplasmic side By similarity HAMAP-Rule MF_01358.

Sequence similarities

Belongs to the complex I 49 kDa subunit family.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   LigandNAD
Ubiquinone
   Molecular functionOxidoreductase
   PTMQuinone
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtransport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentplasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

NADH dehydrogenase (quinone) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

quinone binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 417417NADH-quinone oxidoreductase subunit D HAMAP-Rule MF_01358
PRO_0000371853

Sequences

Sequence LengthMass (Da)Tools
Q83BQ8 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: C917583FA3EAE98E

FASTA41748,119
        10         20         30         40         50         60 
MAEVRNYTFN FGPQHPAAHG VLRLIVEVDG EVIQRIDPHI GLLHRATEKL AESKPYNQTI 

        70         80         90        100        110        120 
GYMDRLDYVS MMANEHGYVL AIEKLLGIEP PIRAKYIRTM FDEITRILNH LLWLGAHALD 

       130        140        150        160        170        180 
VGAMTVFLYC FREREDLMDC YEAVSGARMH ATYYRPGGVY RDLPDSMPKY KPSRWHNEKA 

       190        200        210        220        230        240 
VKKMNEAREG SLLDFIWDFT ARFPNLIDEY ESLLTDNRIW KQRTVGIGVV SAERALQLGF 

       250        260        270        280        290        300 
TGPMLRASGV EWDLRKKQPY AAYDRVDFDI PIGREGDCYD RYLVRIEEMR QSNRIIRQCV 

       310        320        330        340        350        360 
EWLRKNPGSV MIDDYKIVPP QREVMKRDME ALIHHFKLFT EGYIVPEGEA YAAVEQPKGE 

       370        380        390        400        410 
FGVYIVSDGA NKPYRVKVRA ASYPHLAAMN EMCRGHMIAD LVAIISSIDI VFGEIDR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016828 Genomic DNA. Translation: AAO90942.1.
RefSeqNP_820428.1. NC_002971.3.

3D structure databases

ProteinModelPortalQ83BQ8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING227377.CBU_1445.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO90942; AAO90942; CBU_1445.
GeneID1209352.
KEGGcbu:CBU_1445.
PATRIC17931645. VBICoxBur82552_1445.

Phylogenomic databases

eggNOGCOG0649.
HOGENOMHOG000228264.
KOK00333.
OMARIIEQAC.
OrthoDBEOG62G5MP.

Enzyme and pathway databases

BioCycCBUR227377:GJ7S-1433-MONOMER.

Family and domain databases

Gene3D1.10.645.10. 1 hit.
HAMAPMF_01358. NDH1_NuoD.
InterProIPR001135. NADH_Q_OxRdtase_suD.
IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
IPR022885. NDH1_su_D/H.
IPR029014. NiFe_Hase-like.
[Graphical view]
PfamPF00346. Complex1_49kDa. 2 hits.
[Graphical view]
SUPFAMSSF56762. SSF56762. 1 hit.
TIGRFAMsTIGR01962. NuoD. 1 hit.
PROSITEPS00535. COMPLEX1_49K. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNUOD_COXBU
AccessionPrimary (citable) accession number: Q83BQ8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: June 1, 2003
Last modified: June 11, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Coxiella burnetii

Coxiella burnetii (strain RSA 493): entries and gene names