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Protein

Alkyl hydroperoxide reductase AhpD

Gene

ahpD

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.UniRule annotation

Catalytic activityi

2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei133 – 1331Proton donorUniRule annotation
Active sitei136 – 1361Cysteine sulfenic acid (-SOH) intermediateUniRule annotation

GO - Molecular functioni

  1. alkyl hydroperoxide reductase activity Source: UniProtKB-HAMAP
  2. hydroperoxide reductase activity Source: InterPro
  3. peroxidase activity Source: UniProtKB-KW
  4. peroxiredoxin activity Source: UniProtKB-EC

GO - Biological processi

  1. response to oxidative stress Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Oxidoreductase, Peroxidase

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-1466-MONOMER.

Protein family/group databases

PeroxiBasei4610. CbuAhpD_RSA493.

Names & Taxonomyi

Protein namesi
Recommended name:
Alkyl hydroperoxide reductase AhpDUniRule annotation (EC:1.11.1.15UniRule annotation)
Alternative name(s):
Alkylhydroperoxidase AhpDUniRule annotation
Gene namesi
Name:ahpDUniRule annotation
Ordered Locus Names:CBU_1478
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 177177Alkyl hydroperoxide reductase AhpDPRO_0000359485Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi133 ↔ 136By similarity
Disulfide bondi136 – 136Interchain (with AhpC); in linked formUniRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi227377.CBU_1478.

Structurei

3D structure databases

ProteinModelPortaliQ83BM5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AhpD family.UniRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiCOG2128.
HOGENOMiHOG000261487.
KOiK04756.
OMAiRAGLRMN.
OrthoDBiEOG6PCQ0G.

Family and domain databases

Gene3Di1.20.1290.10. 1 hit.
HAMAPiMF_01676. AhpD.
InterProiIPR004674. AhpD.
IPR029032. AhpD-like.
IPR004675. AhpD_core.
IPR003779. CMD-like.
[Graphical view]
PfamiPF02627. CMD. 1 hit.
[Graphical view]
SUPFAMiSSF69118. SSF69118. 1 hit.
TIGRFAMsiTIGR00778. ahpD_dom. 1 hit.

Sequencei

Sequence statusi: Complete.

Q83BM5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLQTYKDQLP DYAKDLKLNL TQVLSESPSS ELSNQQITGV ALAVAYATRN
60 70 80 90 100
RQLIELIFQK AEAELDESTL QAIKAAASIM AMNNIYYRFV HLVKDSEYQR
110 120 130 140 150
LPANLRMNII ANPGIDKKDF ELYSLAVSAI NGCGLCIDAH ANTLIKAGFS
160 170
KHSIQHVIRI AAVLNGLAQV SIIENKT
Length:177
Mass (Da):19,564
Last modified:January 20, 2009 - v3
Checksum:i88F1FEDA6BD68A3B
GO

Sequence cautioni

The sequence AAO90975.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO90975.2. Different initiation.
RefSeqiNP_820461.2. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO90975; AAO90975; CBU_1478.
GeneIDi1209388.
KEGGicbu:CBU_1478.
PATRICi17931717. VBICoxBur82552_1478.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO90975.2. Different initiation.
RefSeqiNP_820461.2. NC_002971.3.

3D structure databases

ProteinModelPortaliQ83BM5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi227377.CBU_1478.

Protein family/group databases

PeroxiBasei4610. CbuAhpD_RSA493.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO90975; AAO90975; CBU_1478.
GeneIDi1209388.
KEGGicbu:CBU_1478.
PATRICi17931717. VBICoxBur82552_1478.

Phylogenomic databases

eggNOGiCOG2128.
HOGENOMiHOG000261487.
KOiK04756.
OMAiRAGLRMN.
OrthoDBiEOG6PCQ0G.

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-1466-MONOMER.

Family and domain databases

Gene3Di1.20.1290.10. 1 hit.
HAMAPiMF_01676. AhpD.
InterProiIPR004674. AhpD.
IPR029032. AhpD-like.
IPR004675. AhpD_core.
IPR003779. CMD-like.
[Graphical view]
PfamiPF02627. CMD. 1 hit.
[Graphical view]
SUPFAMiSSF69118. SSF69118. 1 hit.
TIGRFAMsiTIGR00778. ahpD_dom. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiAHPD_COXBU
AccessioniPrimary (citable) accession number: Q83BM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: January 20, 2009
Last modified: January 7, 2015
This is version 73 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.