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Q83BM5

- AHPD_COXBU

UniProt

Q83BM5 - AHPD_COXBU

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Protein
Alkyl hydroperoxide reductase AhpD
Gene
ahpD, CBU_1478
Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity By similarity.UniRule annotation

Catalytic activityi

2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei133 – 1331Proton donor By similarity
Active sitei136 – 1361Cysteine sulfenic acid (-SOH) intermediate By similarity

GO - Molecular functioni

  1. alkyl hydroperoxide reductase activity Source: UniProtKB-HAMAP
  2. hydroperoxide reductase activity Source: InterPro
  3. peroxidase activity Source: UniProtKB-KW
  4. peroxiredoxin activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. response to oxidative stress Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Oxidoreductase, Peroxidase

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-1466-MONOMER.

Protein family/group databases

PeroxiBasei4610. CbuAhpD_RSA493.

Names & Taxonomyi

Protein namesi
Recommended name:
Alkyl hydroperoxide reductase AhpD (EC:1.11.1.15)
Alternative name(s):
Alkylhydroperoxidase AhpD
Gene namesi
Name:ahpD
Ordered Locus Names:CBU_1478
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 177177Alkyl hydroperoxide reductase AhpDUniRule annotation
PRO_0000359485Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi133 ↔ 136 By similarity
Disulfide bondi136 – 136Interchain (with AhpC); in linked form By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi227377.CBU_1478.

Structurei

3D structure databases

ProteinModelPortaliQ83BM5.

Family & Domainsi

Sequence similaritiesi

Belongs to the AhpD family.

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiCOG2128.
HOGENOMiHOG000261487.
KOiK04756.
OMAiGMNNVWY.
OrthoDBiEOG6PCQ0G.

Family and domain databases

Gene3Di1.20.1290.10. 1 hit.
HAMAPiMF_01676. AhpD.
InterProiIPR004674. AhpD.
IPR029032. AhpD-like.
IPR004675. AhpD_core.
IPR003779. CMD-like.
[Graphical view]
PfamiPF02627. CMD. 1 hit.
[Graphical view]
SUPFAMiSSF69118. SSF69118. 1 hit.
TIGRFAMsiTIGR00778. ahpD_dom. 1 hit.

Sequencei

Sequence statusi: Complete.

Q83BM5-1 [UniParc]FASTAAdd to Basket

« Hide

MLQTYKDQLP DYAKDLKLNL TQVLSESPSS ELSNQQITGV ALAVAYATRN    50
RQLIELIFQK AEAELDESTL QAIKAAASIM AMNNIYYRFV HLVKDSEYQR 100
LPANLRMNII ANPGIDKKDF ELYSLAVSAI NGCGLCIDAH ANTLIKAGFS 150
KHSIQHVIRI AAVLNGLAQV SIIENKT 177
Length:177
Mass (Da):19,564
Last modified:January 20, 2009 - v3
Checksum:i88F1FEDA6BD68A3B
GO

Sequence cautioni

The sequence AAO90975.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016828 Genomic DNA. Translation: AAO90975.2. Different initiation.
RefSeqiNP_820461.2. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO90975; AAO90975; CBU_1478.
GeneIDi1209388.
KEGGicbu:CBU_1478.
PATRICi17931717. VBICoxBur82552_1478.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016828 Genomic DNA. Translation: AAO90975.2 . Different initiation.
RefSeqi NP_820461.2. NC_002971.3.

3D structure databases

ProteinModelPortali Q83BM5.
ModBasei Search...

Protein-protein interaction databases

STRINGi 227377.CBU_1478.

Protein family/group databases

PeroxiBasei 4610. CbuAhpD_RSA493.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO90975 ; AAO90975 ; CBU_1478 .
GeneIDi 1209388.
KEGGi cbu:CBU_1478.
PATRICi 17931717. VBICoxBur82552_1478.

Phylogenomic databases

eggNOGi COG2128.
HOGENOMi HOG000261487.
KOi K04756.
OMAi GMNNVWY.
OrthoDBi EOG6PCQ0G.

Enzyme and pathway databases

BioCyci CBUR227377:GJ7S-1466-MONOMER.

Family and domain databases

Gene3Di 1.20.1290.10. 1 hit.
HAMAPi MF_01676. AhpD.
InterProi IPR004674. AhpD.
IPR029032. AhpD-like.
IPR004675. AhpD_core.
IPR003779. CMD-like.
[Graphical view ]
Pfami PF02627. CMD. 1 hit.
[Graphical view ]
SUPFAMi SSF69118. SSF69118. 1 hit.
TIGRFAMsi TIGR00778. ahpD_dom. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiAHPD_COXBU
AccessioniPrimary (citable) accession number: Q83BM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: January 20, 2009
Last modified: September 3, 2014
This is version 71 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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