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Q83BM5

- AHPD_COXBU

UniProt

Q83BM5 - AHPD_COXBU

Protein

Alkyl hydroperoxide reductase AhpD

Gene

ahpD

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 3 (20 Jan 2009)
      Previous versions | rss
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    Functioni

    Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.UniRule annotation

    Catalytic activityi

    2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei133 – 1331Proton donorUniRule annotation
    Active sitei136 – 1361Cysteine sulfenic acid (-SOH) intermediateUniRule annotation

    GO - Molecular functioni

    1. alkyl hydroperoxide reductase activity Source: UniProtKB-HAMAP
    2. hydroperoxide reductase activity Source: InterPro
    3. peroxidase activity Source: UniProtKB-KW
    4. peroxiredoxin activity Source: UniProtKB-EC

    GO - Biological processi

    1. response to oxidative stress Source: InterPro

    Keywords - Molecular functioni

    Antioxidant, Oxidoreductase, Peroxidase

    Enzyme and pathway databases

    BioCyciCBUR227377:GJ7S-1466-MONOMER.

    Protein family/group databases

    PeroxiBasei4610. CbuAhpD_RSA493.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alkyl hydroperoxide reductase AhpDUniRule annotation (EC:1.11.1.15UniRule annotation)
    Alternative name(s):
    Alkylhydroperoxidase AhpDUniRule annotation
    Gene namesi
    Name:ahpDUniRule annotation
    Ordered Locus Names:CBU_1478
    OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
    Taxonomic identifieri227377 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
    ProteomesiUP000002671: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 177177Alkyl hydroperoxide reductase AhpDPRO_0000359485Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi133 ↔ 136By similarity
    Disulfide bondi136 – 136Interchain (with AhpC); in linked formUniRule annotation

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Protein-protein interaction databases

    STRINGi227377.CBU_1478.

    Structurei

    3D structure databases

    ProteinModelPortaliQ83BM5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AhpD family.UniRule annotation

    Keywords - Domaini

    Redox-active center

    Phylogenomic databases

    eggNOGiCOG2128.
    HOGENOMiHOG000261487.
    KOiK04756.
    OMAiGMNNVWY.
    OrthoDBiEOG6PCQ0G.

    Family and domain databases

    Gene3Di1.20.1290.10. 1 hit.
    HAMAPiMF_01676. AhpD.
    InterProiIPR004674. AhpD.
    IPR029032. AhpD-like.
    IPR004675. AhpD_core.
    IPR003779. CMD-like.
    [Graphical view]
    PfamiPF02627. CMD. 1 hit.
    [Graphical view]
    SUPFAMiSSF69118. SSF69118. 1 hit.
    TIGRFAMsiTIGR00778. ahpD_dom. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q83BM5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLQTYKDQLP DYAKDLKLNL TQVLSESPSS ELSNQQITGV ALAVAYATRN    50
    RQLIELIFQK AEAELDESTL QAIKAAASIM AMNNIYYRFV HLVKDSEYQR 100
    LPANLRMNII ANPGIDKKDF ELYSLAVSAI NGCGLCIDAH ANTLIKAGFS 150
    KHSIQHVIRI AAVLNGLAQV SIIENKT 177
    Length:177
    Mass (Da):19,564
    Last modified:January 20, 2009 - v3
    Checksum:i88F1FEDA6BD68A3B
    GO

    Sequence cautioni

    The sequence AAO90975.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO90975.2. Different initiation.
    RefSeqiNP_820461.2. NC_002971.3.

    Genome annotation databases

    EnsemblBacteriaiAAO90975; AAO90975; CBU_1478.
    GeneIDi1209388.
    KEGGicbu:CBU_1478.
    PATRICi17931717. VBICoxBur82552_1478.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO90975.2 . Different initiation.
    RefSeqi NP_820461.2. NC_002971.3.

    3D structure databases

    ProteinModelPortali Q83BM5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 227377.CBU_1478.

    Protein family/group databases

    PeroxiBasei 4610. CbuAhpD_RSA493.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO90975 ; AAO90975 ; CBU_1478 .
    GeneIDi 1209388.
    KEGGi cbu:CBU_1478.
    PATRICi 17931717. VBICoxBur82552_1478.

    Phylogenomic databases

    eggNOGi COG2128.
    HOGENOMi HOG000261487.
    KOi K04756.
    OMAi GMNNVWY.
    OrthoDBi EOG6PCQ0G.

    Enzyme and pathway databases

    BioCyci CBUR227377:GJ7S-1466-MONOMER.

    Family and domain databases

    Gene3Di 1.20.1290.10. 1 hit.
    HAMAPi MF_01676. AhpD.
    InterProi IPR004674. AhpD.
    IPR029032. AhpD-like.
    IPR004675. AhpD_core.
    IPR003779. CMD-like.
    [Graphical view ]
    Pfami PF02627. CMD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF69118. SSF69118. 1 hit.
    TIGRFAMsi TIGR00778. ahpD_dom. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RSA 493 / Nine Mile phase I.

    Entry informationi

    Entry nameiAHPD_COXBU
    AccessioniPrimary (citable) accession number: Q83BM5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 20, 2009
    Last sequence update: January 20, 2009
    Last modified: October 1, 2014
    This is version 72 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Coxiella burnetii
      Coxiella burnetii (strain RSA 493): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3