Reviewed,
UniProtKB/Swiss-Prot Q83BM5 (AHPD_COXBU)
Last modified
February 9, 2010.
Version 42.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Alkyl hydroperoxide reductase ahpD EC=1.11.1.15 Alternative name(s): Alkylhydroperoxidase ahpD | ||||
| Gene names |
| ||||
| Organism | Coxiella burnetii [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 777 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella |
Protein attributes
| Sequence length | 177 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the ahpC active site cysteine residues and for the regeneration of the ahpC enzyme activity By similarity. HAMAP MF_01676 |
| Catalytic activity | 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. HAMAP MF_01676 |
| Sequence similarities | Belongs to the ahpD family. |
Ontologies
| Keywords | |
|---|---|
| Domain | Redox-active center |
| Molecular function | Antioxidant Oxidoreductase Peroxidase |
| PTM | Disulfide bond |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | alkyl hydroperoxide reductase activity Inferred from electronic annotation. Source: HAMAP peroxiredoxin activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 177 | 177 | Alkyl hydroperoxide reductase ahpD HAMAP MF_01676 | PRO_0000359485 | |||||||
Sites | |||||||||||
| Active site | 133 | 1 | Proton donor By similarity | ||||||||
| Active site | 136 | 1 | Cysteine sulfenic acid (-SOH) intermediate By similarity | ||||||||
Amino acid modifications | |||||||||||
| Disulfide bond | 133 ↔ 136 | Alternate By similarity | |||||||||
| Disulfide bond | 136 | Interchain (with ahpC); in linked form By similarity | |||||||||
Sequences
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References
| [1] | "Complete genome sequence of the Q-fever pathogen, Coxiella burnetii." Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A. Heidelberg J.F.Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed: 12704232] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nine Mile phase I / RSA 493. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE016828 Genomic DNA. Translation: AAO90975.2. Different initiation. |
| RefSeq | NP_820461.2. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1KNC based on UniProtKB P0A5N4. |
| SMR | Q83BM5. Positions 3-171. |
| ModBase | Search... |
Protein family/group databases | |
| PeroxiBase | 4610. CbuAhpD_RSA493. |
Genome annotation databases | |
| GeneID | 1209388. |
| GenomeReviews | Gene locus CBU_1478 in contig AE016828_GR. |
| KEGG | cbu:CBU_1478. |
| NMPDR | fig|227377.1.peg.1405. |
| TIGR | CBU_1478. |
Phylogenomic databases | |
| HOGENOM | HBG414634. |
| OMA | RAGLRMN. |
Enzyme and pathway databases | |
| BioCyc | CBUR227377:CBU_1478-MONOMER. |
Family and domain databases | |
| HAMAP | MF_01676. AhpD. [Tree] |
| InterPro | IPR004674. AhpD. IPR004675. AhpD_core. IPR003779. CMD. [Graphical view] |
| Pfam | PF02627. CMD. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00778. ahpD_dom. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | AHPD_COXBU | ||||||||
| Accession | Primary (citable) accession number: Q83BM5 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Coxiella burnetii Coxiella burnetii (strain RSA 493): entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with


