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Protein
Submitted name:

Virulence-associated protein I

Gene

higA

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • sequence-specific DNA binding Source: InterPro
  • toxic substance binding Source: TIGR

GO - Biological processi

  • plasmid maintenance Source: TIGR
  • response to toxic substance Source: TIGR
Complete GO annotation...

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-1478-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Virulence-associated protein IImported
Gene namesi
Name:higAImported
Ordered Locus Names:CBU_1490Imported
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)Imported
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
Proteomesi
  • UP000002671 Componenti: Chromosome

PTM / Processingi

Proteomic databases

PRIDEiQ83BL4.

Interactioni

Protein-protein interaction databases

STRINGi227377.CBU_1490.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3TRBX-ray2.00A/B3-103[»]
ProteinModelPortaliQ83BL4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 7256HTH cro/C1-type DNA-bindingInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiENOG4105VDM. Bacteria.
COG3093. LUCA.
HOGENOMiHOG000265973.
OMAiGNSAKFW.
OrthoDBiEOG62C9N0.

Family and domain databases

Gene3Di1.10.260.40. 1 hit.
InterProiIPR001387. Cro/C1-type_HTH.
IPR010982. Lambda_DNA-bd_dom.
IPR013430. Toxin_antidote_HigA.
[Graphical view]
PfamiPF01381. HTH_3. 1 hit.
[Graphical view]
SMARTiSM00530. HTH_XRE. 1 hit.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.
TIGRFAMsiTIGR02607. antidote_HigA. 1 hit.
PROSITEiPS50943. HTH_CROC1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q83BL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMAANRMRP IHPGEILAEE LGFLDKMSAN QLAKHLAIPT NRVTAILNGA
60 70 80 90 100
RSITADTALR LAKFFGTTPE FWLNLQDAYD IKMALKKSGK KIEKEVTPYD

QAA
Length:103
Mass (Da):11,458
Last modified:November 4, 2008 - v2
Checksum:iA2BEA9C6E8B013F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO90987.2.
RefSeqiNP_820473.2. NC_002971.3.
WP_010958263.1. NZ_CDBG01000001.1.

Genome annotation databases

EnsemblBacteriaiAAO90987; AAO90987; CBU_1490.
GeneIDi1209400.
KEGGicbu:CBU_1490.
PATRICi17931743. VBICoxBur82552_1491.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO90987.2.
RefSeqiNP_820473.2. NC_002971.3.
WP_010958263.1. NZ_CDBG01000001.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3TRBX-ray2.00A/B3-103[»]
ProteinModelPortaliQ83BL4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi227377.CBU_1490.

Proteomic databases

PRIDEiQ83BL4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO90987; AAO90987; CBU_1490.
GeneIDi1209400.
KEGGicbu:CBU_1490.
PATRICi17931743. VBICoxBur82552_1491.

Phylogenomic databases

eggNOGiENOG4105VDM. Bacteria.
COG3093. LUCA.
HOGENOMiHOG000265973.
OMAiGNSAKFW.
OrthoDBiEOG62C9N0.

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-1478-MONOMER.

Family and domain databases

Gene3Di1.10.260.40. 1 hit.
InterProiIPR001387. Cro/C1-type_HTH.
IPR010982. Lambda_DNA-bd_dom.
IPR013430. Toxin_antidote_HigA.
[Graphical view]
PfamiPF01381. HTH_3. 1 hit.
[Graphical view]
SMARTiSM00530. HTH_XRE. 1 hit.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.
TIGRFAMsiTIGR02607. antidote_HigA. 1 hit.
PROSITEiPS50943. HTH_CROC1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase IImported.
  2. "Comparative genomics reveal extensive transposon-mediated genomic plasticity and diversity among potential effector proteins within the genus Coxiella."
    Beare P.A., Unsworth N., Andoh M., Voth D.E., Omsland A., Gilk S.D., Williams K.P., Sobral B.W., Kupko J.J.III., Porcella S.F., Samuel J.E., Heinzen R.A.
    Infect. Immun. 77:642-656(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase IImported.
  3. "Structural Genomics for Drug Design against the Pathogen Coxiella burnetii."
    Franklin M.C., Cheung J., Rudolph M.J., Burshteyn F., Cassidy M., Gary E., Hillerich B., Yao Z.K., Carlier P.R., Totrov M., Love J.D.
    Proteins 0:0-0(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 3-103.

Entry informationi

Entry nameiQ83BL4_COXBU
AccessioniPrimary (citable) accession number: Q83BL4
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: November 4, 2008
Last modified: March 16, 2016
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.