higA

Functionⁱ

GO - Molecular functionⁱ

sequence-specific DNA binding Source: InterPro
toxic substance binding
Source: TIGR
Inferred from sequence or structural similarityⁱ
- 12704232

GO - Biological processⁱ

plasmid maintenance
Source: TIGR
Inferred from sequence or structural similarityⁱ
- 12704232
response to toxic substance
Source: TIGR
Inferred from sequence or structural similarityⁱ
- 12704232

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Virulence-associated protein IImported
Gene namesⁱ	Name:higAImported Ordered Locus Names:CBU_1490Imported
Organismⁱ	Coxiella burnetii (strain RSA 493 / Nine Mile phase I)Imported
Taxonomic identifierⁱ	227377 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella › Coxiella burnetii
Proteomesⁱ	UP000002671 Componentⁱ: Chromosome

PTM / Processingⁱ

Proteomic databases

PRIDEⁱ	Q83BL4.

PRIDEⁱ

Q83BL4.

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	227377.CBU_1490.

STRINGⁱ

227377.CBU_1490.

Structureⁱ

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3TRB	X-ray	2.00	A/B	3-103	[»]
ProteinModelPortalⁱ	Q83BL4.
SMRⁱ	Q83BL4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	17 – 72	HTH cro/C1-type DNA-bindingInterPro annotationAdd BLAST		56

Phylogenomic databases

eggNOGⁱ	ENOG4105VDM. Bacteria. COG3093. LUCA.
HOGENOMⁱ	HOG000265973.
OMAⁱ	GNSAKFW.

Family and domain databases

InterProⁱ	View protein in InterPro IPR001387. Cro/C1-type_HTH. IPR010982. Lambda_DNA-bd_dom. IPR013430. Toxin_antidote_HigA.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01381. HTH_3. 1 hit.
SMARTⁱ	View protein in SMART SM00530. HTH_XRE. 1 hit.
SUPFAMⁱ	SSF47413. SSF47413. 1 hit.
TIGRFAMsⁱ	TIGR02607. antidote_HigA. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50943. HTH_CROC1. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q83BL4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKMAANRMRP IHPGEILAEE LGFLDKMSAN QLAKHLAIPT NRVTAILNGA 
        60         70         80         90        100
RSITADTALR LAKFFGTTPE FWLNLQDAYD IKMALKKSGK KIEKEVTPYD 

QAA

Length:103

Mass (Da):11,458

Last modified:November 4, 2008 - v2

Checksum:ⁱA2BEA9C6E8B013F8

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE016828 Genomic DNA. Translation: AAO90987.2.
NCBI Reference Sequences More...RefSeqⁱ	NP_820473.2. NC_002971.3. WP_010958263.1. NZ_CDBG01000001.1.

Genome annotation databases

EnsemblBacteriaⁱ	AAO90987; AAO90987; CBU_1490.
GeneIDⁱ	1209400. 31483172.
KEGGⁱ	cbu:CBU_1490.
PATRICⁱ	fig\|227377.7.peg.1491.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE016828 Genomic DNA. Translation: AAO90987.2.
NCBI Reference Sequences More...RefSeqⁱ	NP_820473.2. NC_002971.3. WP_010958263.1. NZ_CDBG01000001.1.

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3TRB	X-ray	2.00	A/B	3-103	[»]
ProteinModelPortalⁱ	Q83BL4.
SMRⁱ	Q83BL4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	227377.CBU_1490.

STRINGⁱ

227377.CBU_1490.

Proteomic databases

PRIDEⁱ	Q83BL4.

PRIDEⁱ

Q83BL4.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAO90987; AAO90987; CBU_1490.
GeneIDⁱ	1209400. 31483172.
KEGGⁱ	cbu:CBU_1490.
PATRICⁱ	fig\|227377.7.peg.1491.

Phylogenomic databases

eggNOGⁱ	ENOG4105VDM. Bacteria. COG3093. LUCA.
HOGENOMⁱ	HOG000265973.
OMAⁱ	GNSAKFW.

Family and domain databases

InterProⁱ	View protein in InterPro IPR001387. Cro/C1-type_HTH. IPR010982. Lambda_DNA-bd_dom. IPR013430. Toxin_antidote_HigA.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01381. HTH_3. 1 hit.
SMARTⁱ	View protein in SMART SM00530. HTH_XRE. 1 hit.
SUPFAMⁱ	SSF47413. SSF47413. 1 hit.
TIGRFAMsⁱ	TIGR02607. antidote_HigA. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50943. HTH_CROC1. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q83BL4_COXBU
Accessionⁱ	Q83BL4Primary (citable) accession number: Q83BL4
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	June 1, 2003
	Last sequence update:	November 4, 2008
	Last modified:	July 5, 2017
	This is version 85 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structureCombined sources, Complete proteome, Reference proteomeImported

UniProtKB - Q83BL4 (Q83BL4_COXBU)

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Virulence-associated protein I

Select a section on the left to see content.

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Proteomic databases

Interactionⁱ

Protein-protein interaction databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q83BL4 (Q83BL4_COXBU)

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Virulence-associated protein I

higA

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ