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Q83BL1

- PDXJ_COXBU

UniProt

Q83BL1 - PDXJ_COXBU

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Protein

Pyridoxine 5'-phosphate synthase

Gene

pdxJ

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.UniRule annotation

Catalytic activityi

1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = pyridoxine 5'-phosphate + phosphate + 2 H2O.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei7 – 713-amino-2-oxopropyl phosphateUniRule annotation
Binding sitei18 – 1813-amino-2-oxopropyl phosphateUniRule annotation
Active sitei43 – 431Proton acceptorUniRule annotation
Binding sitei45 – 4511-deoxy-D-xylulose 5-phosphateUniRule annotation
Binding sitei50 – 5011-deoxy-D-xylulose 5-phosphateUniRule annotation
Active sitei70 – 701Proton acceptorUniRule annotation
Binding sitei100 – 10011-deoxy-D-xylulose 5-phosphateUniRule annotation
Sitei151 – 1511Transition state stabilizerUniRule annotation
Active sitei191 – 1911Proton donorUniRule annotation
Binding sitei192 – 19213-amino-2-oxopropyl phosphate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. pyridoxine 5'-phosphate synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Pyridoxine biosynthesis

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-1482-MONOMER.
UniPathwayiUPA00244; UER00313.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyridoxine 5'-phosphate synthaseUniRule annotation (EC:2.6.99.2UniRule annotation)
Short name:
PNP synthaseUniRule annotation
Gene namesi
Name:pdxJUniRule annotation
Ordered Locus Names:CBU_1494
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Pyridoxine 5'-phosphate synthasePRO_0000231800Add
BLAST

Interactioni

Subunit structurei

Homooctamer; tetramer of dimers.UniRule annotation

Protein-protein interaction databases

STRINGi227377.CBU_1494.

Structurei

3D structure databases

ProteinModelPortaliQ83BL1.
SMRiQ83BL1. Positions 4-240.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni9 – 1021-deoxy-D-xylulose 5-phosphate bindingUniRule annotation
Regioni213 – 21423-amino-2-oxopropyl phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the PNP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0854.
HOGENOMiHOG000258094.
KOiK03474.
OMAiVPETRQE.
OrthoDBiEOG6M9F0H.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00279. PdxJ.
InterProiIPR013785. Aldolase_TIM.
IPR004569. PyrdxlP_synth_PdxJ.
[Graphical view]
PfamiPF03740. PdxJ. 1 hit.
[Graphical view]
SUPFAMiSSF63892. SSF63892. 1 hit.
TIGRFAMsiTIGR00559. pdxJ. 1 hit.

Sequencei

Sequence statusi: Complete.

Q83BL1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVRLGVNIDH IATLRQARGV DYPDPVEAAM MAIEAGADGI TLHLREDRRH
60 70 80 90 100
IQDDDVRNLK RKLTVPMNLE MATAEDIIQF AEEIKPEHCC LVPEKREELT
110 120 130 140 150
TEGGLDVAGQ QNTLKKVCAR LAKVGIEVSL FIDPEEKQID AAKAAGAPVI
160 170 180 190 200
EIHTGHYANA KTDHEHNQQL KRIADAAAYA DSLGLTVNAG HGLTIHNVQS
210 220 230 240
IAAIPVINEL NIGHSIISRG VLIGLAEAVK EMKTLIAGAQ
Length:240
Mass (Da):26,013
Last modified:June 1, 2003 - v1
Checksum:iE15A78207718D673
GO

Sequence cautioni

The sequence AAO90991.2 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016828 Genomic DNA. Translation: AAO90991.2. Different initiation.
RefSeqiNP_820477.2. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO90991; AAO90991; CBU_1494.
GeneIDi1209404.
KEGGicbu:CBU_1494.
PATRICi17931753. VBICoxBur82552_1496.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016828 Genomic DNA. Translation: AAO90991.2 . Different initiation.
RefSeqi NP_820477.2. NC_002971.3.

3D structure databases

ProteinModelPortali Q83BL1.
SMRi Q83BL1. Positions 4-240.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227377.CBU_1494.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO90991 ; AAO90991 ; CBU_1494 .
GeneIDi 1209404.
KEGGi cbu:CBU_1494.
PATRICi 17931753. VBICoxBur82552_1496.

Phylogenomic databases

eggNOGi COG0854.
HOGENOMi HOG000258094.
KOi K03474.
OMAi VPETRQE.
OrthoDBi EOG6M9F0H.

Enzyme and pathway databases

UniPathwayi UPA00244 ; UER00313 .
BioCyci CBUR227377:GJ7S-1482-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00279. PdxJ.
InterProi IPR013785. Aldolase_TIM.
IPR004569. PyrdxlP_synth_PdxJ.
[Graphical view ]
Pfami PF03740. PdxJ. 1 hit.
[Graphical view ]
SUPFAMi SSF63892. SSF63892. 1 hit.
TIGRFAMsi TIGR00559. pdxJ. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiPDXJ_COXBU
AccessioniPrimary (citable) accession number: Q83BL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3