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Protein

Glycerol-3-phosphate dehydrogenase [NAD(P)+]

Gene

gpsA

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H.UniRule annotation

Pathway:iglycerophospholipid metabolism

This protein is involved in the pathway glycerophospholipid metabolism, which is part of Membrane lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycerophospholipid metabolism and in Membrane lipid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei110 – 1101NAD; via amide nitrogenUniRule annotation
Binding sitei110 – 1101SubstrateUniRule annotation
Binding sitei141 – 1411NAD; via amide nitrogenUniRule annotation
Active sitei192 – 1921Proton acceptorUniRule annotation
Binding sitei256 – 2561NADUniRule annotation
Binding sitei282 – 2821NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 176NADUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-1503-MONOMER.
UniPathwayiUPA00940.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(P)+]UniRule annotation (EC:1.1.1.94UniRule annotation)
Alternative name(s):
NAD(P)H-dependent glycerol-3-phosphate dehydrogenaseUniRule annotation
Gene namesi
Name:gpsAUniRule annotation
Ordered Locus Names:CBU_1518
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 332332Glycerol-3-phosphate dehydrogenase [NAD(P)+]PRO_0000137953Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi227377.CBU_1518.

Structurei

Secondary structure

1
332
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi8 – 114Combined sources
Helixi15 – 2511Combined sources
Turni26 – 283Combined sources
Beta strandi31 – 344Combined sources
Helixi38 – 4710Combined sources
Beta strandi48 – 503Combined sources
Turni51 – 533Combined sources
Beta strandi63 – 675Combined sources
Helixi69 – 735Combined sources
Beta strandi78 – 814Combined sources
Helixi85 – 9511Combined sources
Helixi96 – 983Combined sources
Beta strandi104 – 1074Combined sources
Turni114 – 1163Combined sources
Helixi119 – 1279Combined sources
Beta strandi132 – 1387Combined sources
Helixi141 – 1455Combined sources
Beta strandi150 – 1578Combined sources
Helixi159 – 16911Combined sources
Beta strandi172 – 1809Combined sources
Helixi182 – 20423Combined sources
Helixi209 – 22921Combined sources
Helixi234 – 2374Combined sources
Turni240 – 2423Combined sources
Helixi243 – 2519Combined sources
Helixi256 – 26611Combined sources
Helixi270 – 2778Combined sources
Helixi283 – 29614Combined sources
Helixi302 – 31211Combined sources
Helixi317 – 3259Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3K96X-ray2.10A/B1-332[»]
ProteinModelPortaliQ83BJ0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ83BJ0.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni256 – 2572Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0240.
HOGENOMiHOG000246854.
KOiK00057.
OMAiRNHTAGR.
OrthoDBiEOG6JDWF4.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPiMF_00394. NAD_Glyc3P_dehydrog.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q83BJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPFKHPIAI LGAGSWGTAL ALVLARKGQK VRLWSYESDH VDEMQAEGVN
60 70 80 90 100
NRYLPNYPFP ETLKAYCDLK ASLEGVTDIL IVVPSFAFHE VITRMKPLID
110 120 130 140 150
AKTRIAWGTK GLAKGSRLLH EVVATELGQV PMAVISGPSL ATEVAANLPT
160 170 180 190 200
AVSLASNNSQ FSKDLIERLH GQRFRVYKND DMIGVELCGS VKNILAIATG
210 220 230 240 250
ISDGLKLGSN ARAALITRGL TEMGRLVSVF GGKQETLTGL AGLGDLVLTC
260 270 280 290 300
TDNQSRNRRF GLALGEGVDK KEAQQAIGQA IEGLYNTDQV HALAQKHAIE
310 320 330
MPLTFQVHRI LHEDLDPQQA VQELLERSPK AE
Length:332
Mass (Da):36,067
Last modified:June 1, 2003 - v1
Checksum:i0790551553B52A94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO91015.1.
RefSeqiNP_820501.1. NC_002971.3.
WP_010958277.1. NZ_CCYB01000022.1.

Genome annotation databases

EnsemblBacteriaiAAO91015; AAO91015; CBU_1518.
GeneIDi1209428.
KEGGicbu:CBU_1518.
PATRICi17931803. VBICoxBur82552_1521.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016828 Genomic DNA. Translation: AAO91015.1.
RefSeqiNP_820501.1. NC_002971.3.
WP_010958277.1. NZ_CCYB01000022.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3K96X-ray2.10A/B1-332[»]
ProteinModelPortaliQ83BJ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi227377.CBU_1518.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO91015; AAO91015; CBU_1518.
GeneIDi1209428.
KEGGicbu:CBU_1518.
PATRICi17931803. VBICoxBur82552_1521.

Phylogenomic databases

eggNOGiCOG0240.
HOGENOMiHOG000246854.
KOiK00057.
OMAiRNHTAGR.
OrthoDBiEOG6JDWF4.

Enzyme and pathway databases

UniPathwayiUPA00940.
BioCyciCBUR227377:GJ7S-1503-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ83BJ0.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPiMF_00394. NAD_Glyc3P_dehydrog.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiGPDA_COXBU
AccessioniPrimary (citable) accession number: Q83BJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: June 1, 2003
Last modified: July 22, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.