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Q83BJ0

- GPDA_COXBU

UniProt

Q83BJ0 - GPDA_COXBU

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Protein

Glycerol-3-phosphate dehydrogenase [NAD(P)+]

Gene
gpsA, CBU_1518
Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei110 – 1101NAD; via amide nitrogen By similarity
Binding sitei110 – 1101Substrate By similarity
Binding sitei141 – 1411NAD; via amide nitrogen By similarity
Active sitei192 – 1921Proton acceptor By similarity
Binding sitei256 – 2561NAD By similarity
Binding sitei282 – 2821NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 176NAD By similarity

GO - Molecular functioni

  1. glycerol-3-phosphate dehydrogenase [NAD(P)+] activity Source: UniProtKB-HAMAP
  2. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
  3. glycerol-3-phosphate dehydrogenase [NADP+] activity Source: UniProtKB-EC
  4. NAD binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. glycerol-3-phosphate biosynthetic process Source: UniProtKB-HAMAP
  3. glycerol-3-phosphate catabolic process Source: InterPro
  4. glycerophospholipid metabolic process Source: UniProtKB-UniPathway
  5. phospholipid biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-1503-MONOMER.
UniPathwayiUPA00940.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC:1.1.1.94)
Alternative name(s):
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase
Gene namesi
Name:gpsA
Ordered Locus Names:CBU_1518
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 332332Glycerol-3-phosphate dehydrogenase [NAD(P)+]UniRule annotationPRO_0000137953Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi227377.CBU_1518.

Structurei

Secondary structure

1
332
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi8 – 114
Helixi15 – 2511
Turni26 – 283
Beta strandi31 – 344
Helixi38 – 4710
Beta strandi48 – 503
Turni51 – 533
Beta strandi63 – 675
Helixi69 – 735
Beta strandi78 – 814
Helixi85 – 9511
Helixi96 – 983
Beta strandi104 – 1074
Turni114 – 1163
Helixi119 – 1279
Beta strandi132 – 1387
Helixi141 – 1455
Beta strandi150 – 1578
Helixi159 – 16911
Beta strandi172 – 1809
Helixi182 – 20423
Helixi209 – 22921
Helixi234 – 2374
Turni240 – 2423
Helixi243 – 2519
Helixi256 – 26611
Helixi270 – 2778
Helixi283 – 29614
Helixi302 – 31211
Helixi317 – 3259

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3K96X-ray2.10A/B1-332[»]
ProteinModelPortaliQ83BJ0.

Miscellaneous databases

EvolutionaryTraceiQ83BJ0.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni256 – 2572Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0240.
HOGENOMiHOG000246854.
KOiK00057.
OMAiHLLHCGK.
OrthoDBiEOG6JDWF4.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPiMF_00394. NAD_Glyc3P_dehydrog.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q83BJ0-1 [UniParc]FASTAAdd to Basket

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MEPFKHPIAI LGAGSWGTAL ALVLARKGQK VRLWSYESDH VDEMQAEGVN    50
NRYLPNYPFP ETLKAYCDLK ASLEGVTDIL IVVPSFAFHE VITRMKPLID 100
AKTRIAWGTK GLAKGSRLLH EVVATELGQV PMAVISGPSL ATEVAANLPT 150
AVSLASNNSQ FSKDLIERLH GQRFRVYKND DMIGVELCGS VKNILAIATG 200
ISDGLKLGSN ARAALITRGL TEMGRLVSVF GGKQETLTGL AGLGDLVLTC 250
TDNQSRNRRF GLALGEGVDK KEAQQAIGQA IEGLYNTDQV HALAQKHAIE 300
MPLTFQVHRI LHEDLDPQQA VQELLERSPK AE 332
Length:332
Mass (Da):36,067
Last modified:June 1, 2003 - v1
Checksum:i0790551553B52A94
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016828 Genomic DNA. Translation: AAO91015.1.
RefSeqiNP_820501.1. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO91015; AAO91015; CBU_1518.
GeneIDi1209428.
KEGGicbu:CBU_1518.
PATRICi17931803. VBICoxBur82552_1521.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016828 Genomic DNA. Translation: AAO91015.1 .
RefSeqi NP_820501.1. NC_002971.3.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3K96 X-ray 2.10 A/B 1-332 [» ]
ProteinModelPortali Q83BJ0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227377.CBU_1518.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO91015 ; AAO91015 ; CBU_1518 .
GeneIDi 1209428.
KEGGi cbu:CBU_1518.
PATRICi 17931803. VBICoxBur82552_1521.

Phylogenomic databases

eggNOGi COG0240.
HOGENOMi HOG000246854.
KOi K00057.
OMAi HLLHCGK.
OrthoDBi EOG6JDWF4.

Enzyme and pathway databases

UniPathwayi UPA00940 .
BioCyci CBUR227377:GJ7S-1503-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q83BJ0.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPi MF_00394. NAD_Glyc3P_dehydrog.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11728. PTHR11728. 1 hit.
Pfami PF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSi PR00077. GPDHDRGNASE.
SUPFAMi SSF48179. SSF48179. 1 hit.
PROSITEi PS00957. NAD_G3PDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiGPDA_COXBU
AccessioniPrimary (citable) accession number: Q83BJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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