Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q83BJ0

- GPDA_COXBU

UniProt

Q83BJ0 - GPDA_COXBU

Protein

Glycerol-3-phosphate dehydrogenase [NAD(P)+]

Gene

gpsA

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei110 – 1101NAD; via amide nitrogenUniRule annotation
    Binding sitei110 – 1101SubstrateUniRule annotation
    Binding sitei141 – 1411NAD; via amide nitrogenUniRule annotation
    Active sitei192 – 1921Proton acceptorUniRule annotation
    Binding sitei256 – 2561NADUniRule annotation
    Binding sitei282 – 2821NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 176NADUniRule annotation

    GO - Molecular functioni

    1. glycerol-3-phosphate dehydrogenase [NAD(P)+] activity Source: UniProtKB-HAMAP
    2. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
    3. glycerol-3-phosphate dehydrogenase [NADP+] activity Source: UniProtKB-EC
    4. NAD binding Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. glycerol-3-phosphate biosynthetic process Source: UniProtKB-HAMAP
    3. glycerol-3-phosphate catabolic process Source: InterPro
    4. glycerophospholipid metabolic process Source: UniProtKB-UniPathway
    5. phospholipid biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciCBUR227377:GJ7S-1503-MONOMER.
    UniPathwayiUPA00940.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycerol-3-phosphate dehydrogenase [NAD(P)+]UniRule annotation (EC:1.1.1.94UniRule annotation)
    Alternative name(s):
    NAD(P)H-dependent glycerol-3-phosphate dehydrogenaseUniRule annotation
    Gene namesi
    Name:gpsAUniRule annotation
    Ordered Locus Names:CBU_1518
    OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
    Taxonomic identifieri227377 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
    ProteomesiUP000002671: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. glycerol-3-phosphate dehydrogenase complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 332332Glycerol-3-phosphate dehydrogenase [NAD(P)+]PRO_0000137953Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi227377.CBU_1518.

    Structurei

    Secondary structure

    1
    332
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi8 – 114
    Helixi15 – 2511
    Turni26 – 283
    Beta strandi31 – 344
    Helixi38 – 4710
    Beta strandi48 – 503
    Turni51 – 533
    Beta strandi63 – 675
    Helixi69 – 735
    Beta strandi78 – 814
    Helixi85 – 9511
    Helixi96 – 983
    Beta strandi104 – 1074
    Turni114 – 1163
    Helixi119 – 1279
    Beta strandi132 – 1387
    Helixi141 – 1455
    Beta strandi150 – 1578
    Helixi159 – 16911
    Beta strandi172 – 1809
    Helixi182 – 20423
    Helixi209 – 22921
    Helixi234 – 2374
    Turni240 – 2423
    Helixi243 – 2519
    Helixi256 – 26611
    Helixi270 – 2778
    Helixi283 – 29614
    Helixi302 – 31211
    Helixi317 – 3259

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3K96X-ray2.10A/B1-332[»]
    ProteinModelPortaliQ83BJ0.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ83BJ0.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni256 – 2572Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0240.
    HOGENOMiHOG000246854.
    KOiK00057.
    OMAiHLLHCGK.
    OrthoDBiEOG6JDWF4.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    HAMAPiMF_00394. NAD_Glyc3P_dehydrog.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR006168. G3P_DH_NAD-dep.
    IPR006109. G3P_DH_NAD-dep_C.
    IPR011128. G3P_DH_NAD-dep_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11728. PTHR11728. 1 hit.
    PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
    PF01210. NAD_Gly3P_dh_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
    PRINTSiPR00077. GPDHDRGNASE.
    SUPFAMiSSF48179. SSF48179. 1 hit.
    PROSITEiPS00957. NAD_G3PDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q83BJ0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPFKHPIAI LGAGSWGTAL ALVLARKGQK VRLWSYESDH VDEMQAEGVN    50
    NRYLPNYPFP ETLKAYCDLK ASLEGVTDIL IVVPSFAFHE VITRMKPLID 100
    AKTRIAWGTK GLAKGSRLLH EVVATELGQV PMAVISGPSL ATEVAANLPT 150
    AVSLASNNSQ FSKDLIERLH GQRFRVYKND DMIGVELCGS VKNILAIATG 200
    ISDGLKLGSN ARAALITRGL TEMGRLVSVF GGKQETLTGL AGLGDLVLTC 250
    TDNQSRNRRF GLALGEGVDK KEAQQAIGQA IEGLYNTDQV HALAQKHAIE 300
    MPLTFQVHRI LHEDLDPQQA VQELLERSPK AE 332
    Length:332
    Mass (Da):36,067
    Last modified:June 1, 2003 - v1
    Checksum:i0790551553B52A94
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO91015.1.
    RefSeqiNP_820501.1. NC_002971.3.

    Genome annotation databases

    EnsemblBacteriaiAAO91015; AAO91015; CBU_1518.
    GeneIDi1209428.
    KEGGicbu:CBU_1518.
    PATRICi17931803. VBICoxBur82552_1521.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO91015.1 .
    RefSeqi NP_820501.1. NC_002971.3.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3K96 X-ray 2.10 A/B 1-332 [» ]
    ProteinModelPortali Q83BJ0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 227377.CBU_1518.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO91015 ; AAO91015 ; CBU_1518 .
    GeneIDi 1209428.
    KEGGi cbu:CBU_1518.
    PATRICi 17931803. VBICoxBur82552_1521.

    Phylogenomic databases

    eggNOGi COG0240.
    HOGENOMi HOG000246854.
    KOi K00057.
    OMAi HLLHCGK.
    OrthoDBi EOG6JDWF4.

    Enzyme and pathway databases

    UniPathwayi UPA00940 .
    BioCyci CBUR227377:GJ7S-1503-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q83BJ0.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    HAMAPi MF_00394. NAD_Glyc3P_dehydrog.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR006168. G3P_DH_NAD-dep.
    IPR006109. G3P_DH_NAD-dep_C.
    IPR011128. G3P_DH_NAD-dep_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11728. PTHR11728. 1 hit.
    Pfami PF07479. NAD_Gly3P_dh_C. 1 hit.
    PF01210. NAD_Gly3P_dh_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000114. Glycerol-3-P_dh. 1 hit.
    PRINTSi PR00077. GPDHDRGNASE.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    PROSITEi PS00957. NAD_G3PDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RSA 493 / Nine Mile phase I.

    Entry informationi

    Entry nameiGPDA_COXBU
    AccessioniPrimary (citable) accession number: Q83BJ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Coxiella burnetii
      Coxiella burnetii (strain RSA 493): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3