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Q83BE2

- RUVA_COXBU

UniProt

Q83BE2 - RUVA_COXBU

Protein

Holliday junction ATP-dependent DNA helicase RuvA

Gene

ruvA

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.UniRule annotation

    Catalytic activityi

    ATP + H2O = ADP + phosphate.UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: UniProtKB-KW
    3. four-way junction helicase activity Source: InterPro

    GO - Biological processi

    1. DNA recombination Source: UniProtKB-KW
    2. DNA repair Source: UniProtKB-KW
    3. SOS response Source: UniProtKB-KW

    Keywords - Molecular functioni

    Helicase, Hydrolase

    Keywords - Biological processi

    DNA damage, DNA recombination, DNA repair, SOS response

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCBUR227377:GJ7S-1547-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Holliday junction ATP-dependent DNA helicase RuvAUniRule annotation (EC:3.6.4.12UniRule annotation)
    Gene namesi
    Name:ruvAUniRule annotation
    Ordered Locus Names:CBU_1568
    OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
    Taxonomic identifieri227377 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
    ProteomesiUP000002671: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. Holliday junction helicase complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 200200Holliday junction ATP-dependent DNA helicase RuvAPRO_0000094627Add
    BLAST

    Interactioni

    Subunit structurei

    Forms a complex with RuvB.UniRule annotation

    Protein-protein interaction databases

    STRINGi227377.CBU_1568.

    Structurei

    3D structure databases

    ProteinModelPortaliQ83BE2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RuvA family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0632.
    HOGENOMiHOG000057116.
    KOiK03550.
    OMAiGYKPQQA.
    OrthoDBiEOG679THG.

    Family and domain databases

    Gene3Di2.40.50.140. 1 hit.
    HAMAPiMF_00031. DNA_helic_RuvA.
    InterProiIPR011114. DNA_helicas_Holl-junc_RuvA_C.
    IPR013849. DNA_helicase_Holl-junc_RuvA_I.
    IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
    IPR012340. NA-bd_OB-fold.
    IPR000085. RuvA.
    IPR010994. RuvA_2-like.
    [Graphical view]
    PfamiPF07499. RuvA_C. 1 hit.
    PF01330. RuvA_N. 1 hit.
    [Graphical view]
    SMARTiSM00278. HhH1. 2 hits.
    [Graphical view]
    SUPFAMiSSF46929. SSF46929. 1 hit.
    SSF47781. SSF47781. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00084. ruvA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q83BE2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIGHLRGIIV EKQPPYLLLE VAGVGYEITA PLSTFYHLPE PQEEILLYTH    50
    LIVREDAHTL YGFHNDHERR LFRALIKVNG VGPKLALAIL SGIGPDEFVH 100
    CVLNQNIDQL VRIPGVGRKT AERLVIETKD GLSRWHTNDT PSPEGLRSSN 150
    TQPTQDAISA LMALGYKPQE AKRAIDAIQK PDLSAETLIR LALKQMVLGT 200
    Length:200
    Mass (Da):22,225
    Last modified:June 1, 2003 - v1
    Checksum:i1C48A1F35D1CC2DE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO91065.1.
    RefSeqiNP_820551.1. NC_002971.3.

    Genome annotation databases

    EnsemblBacteriaiAAO91065; AAO91065; CBU_1568.
    GeneIDi1209478.
    KEGGicbu:CBU_1568.
    PATRICi17931899. VBICoxBur82552_1569.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO91065.1 .
    RefSeqi NP_820551.1. NC_002971.3.

    3D structure databases

    ProteinModelPortali Q83BE2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 227377.CBU_1568.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO91065 ; AAO91065 ; CBU_1568 .
    GeneIDi 1209478.
    KEGGi cbu:CBU_1568.
    PATRICi 17931899. VBICoxBur82552_1569.

    Phylogenomic databases

    eggNOGi COG0632.
    HOGENOMi HOG000057116.
    KOi K03550.
    OMAi GYKPQQA.
    OrthoDBi EOG679THG.

    Enzyme and pathway databases

    BioCyci CBUR227377:GJ7S-1547-MONOMER.

    Family and domain databases

    Gene3Di 2.40.50.140. 1 hit.
    HAMAPi MF_00031. DNA_helic_RuvA.
    InterProi IPR011114. DNA_helicas_Holl-junc_RuvA_C.
    IPR013849. DNA_helicase_Holl-junc_RuvA_I.
    IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
    IPR012340. NA-bd_OB-fold.
    IPR000085. RuvA.
    IPR010994. RuvA_2-like.
    [Graphical view ]
    Pfami PF07499. RuvA_C. 1 hit.
    PF01330. RuvA_N. 1 hit.
    [Graphical view ]
    SMARTi SM00278. HhH1. 2 hits.
    [Graphical view ]
    SUPFAMi SSF46929. SSF46929. 1 hit.
    SSF47781. SSF47781. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00084. ruvA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RSA 493 / Nine Mile phase I.

    Entry informationi

    Entry nameiRUVA_COXBU
    AccessioniPrimary (citable) accession number: Q83BE2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Coxiella burnetii
      Coxiella burnetii (strain RSA 493): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3