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Q83BE0

- RUVB_COXBU

UniProt

Q83BE0 - RUVB_COXBU

Protein

Holliday junction ATP-dependent DNA helicase RuvB

Gene

ruvB

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.UniRule annotation

    Catalytic activityi

    ATP + H2O = ADP + phosphate.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi64 – 718ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. four-way junction helicase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA recombination Source: UniProtKB-HAMAP
    2. DNA repair Source: UniProtKB-HAMAP
    3. SOS response Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Helicase, Hydrolase

    Keywords - Biological processi

    DNA damage, DNA recombination, DNA repair, SOS response

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCBUR227377:GJ7S-1549-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Holliday junction ATP-dependent DNA helicase RuvBUniRule annotation (EC:3.6.4.12UniRule annotation)
    Gene namesi
    Name:ruvBUniRule annotation
    Ordered Locus Names:CBU_1570
    OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
    Taxonomic identifieri227377 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
    ProteomesiUP000002671: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 351351Holliday junction ATP-dependent DNA helicase RuvBPRO_0000165525Add
    BLAST

    Interactioni

    Subunit structurei

    Forms a complex with RuvA.UniRule annotation

    Protein-protein interaction databases

    STRINGi227377.CBU_1570.

    Structurei

    3D structure databases

    ProteinModelPortaliQ83BE0.
    SMRiQ83BE0. Positions 24-336.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RuvB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2255.
    HOGENOMiHOG000218623.
    KOiK03551.
    OMAiDYAEVKH.
    OrthoDBiEOG6SR93S.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    3.40.50.300. 2 hits.
    HAMAPiMF_00016. DNA_helic_RuvB.
    InterProiIPR003593. AAA+_ATPase.
    IPR004605. DNA_helicase_Holl-junc_RuvB.
    IPR008823. DNA_helicase_Holl-junc_RuvB_C.
    IPR008824. DNA_helicase_Holl-junc_RuvB_N.
    IPR027417. P-loop_NTPase.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF05491. RuvB_C. 1 hit.
    PF05496. RuvB_N. 1 hit.
    [Graphical view]
    ProDomiPD005323. DNA_helicase_Holl-junc_RuvB_C. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00635. ruvB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q83BE0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDEKIETRLI GATVQSNEPD LERSIRPKRL SDYIGQAAVR EQMDIFIRAA    50
    TNRREALDHV LIFGPPGLGK TTLAHIIAHE MQAGLKQTSG PVLEKAGDLA 100
    ALLTNLEPHD VLFIDEIHRL NPAIEEVLYP ALEDFQLDII IGEGPSARSI 150
    KLDLPPFTLV GATTRAGLLT SPLRDRFGIV QRLEFYRIPD LIHIVKRAAH 200
    ILNVVIDENG AGEIARRSRG TPRIANRLLR RVRDFAEVRA NGMINESIAK 250
    EALDLLNVDI RGLDVMDRKL LETIIKKFQG GPVGIESLAA AISEERGTIE 300
    DVIEPYLIQE GFILRTPRGR IATELTYQHF KLPLPTQSTL QENFDLLGKV 350
    E 351
    Length:351
    Mass (Da):39,151
    Last modified:June 1, 2003 - v1
    Checksum:i7A69DB0B71CC72FF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO91067.1.
    RefSeqiNP_820553.1. NC_002971.3.

    Genome annotation databases

    EnsemblBacteriaiAAO91067; AAO91067; CBU_1570.
    GeneIDi1209480.
    KEGGicbu:CBU_1570.
    PATRICi17931903. VBICoxBur82552_1571.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO91067.1 .
    RefSeqi NP_820553.1. NC_002971.3.

    3D structure databases

    ProteinModelPortali Q83BE0.
    SMRi Q83BE0. Positions 24-336.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 227377.CBU_1570.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO91067 ; AAO91067 ; CBU_1570 .
    GeneIDi 1209480.
    KEGGi cbu:CBU_1570.
    PATRICi 17931903. VBICoxBur82552_1571.

    Phylogenomic databases

    eggNOGi COG2255.
    HOGENOMi HOG000218623.
    KOi K03551.
    OMAi DYAEVKH.
    OrthoDBi EOG6SR93S.

    Enzyme and pathway databases

    BioCyci CBUR227377:GJ7S-1549-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    3.40.50.300. 2 hits.
    HAMAPi MF_00016. DNA_helic_RuvB.
    InterProi IPR003593. AAA+_ATPase.
    IPR004605. DNA_helicase_Holl-junc_RuvB.
    IPR008823. DNA_helicase_Holl-junc_RuvB_C.
    IPR008824. DNA_helicase_Holl-junc_RuvB_N.
    IPR027417. P-loop_NTPase.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF05491. RuvB_C. 1 hit.
    PF05496. RuvB_N. 1 hit.
    [Graphical view ]
    ProDomi PD005323. DNA_helicase_Holl-junc_RuvB_C. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00635. ruvB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RSA 493 / Nine Mile phase I.

    Entry informationi

    Entry nameiRUVB_COXBU
    AccessioniPrimary (citable) accession number: Q83BE0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Coxiella burnetii
      Coxiella burnetii (strain RSA 493): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3