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Q83B09

- GCSPB_COXBU

UniProt

Q83B09 - GCSPB_COXBU

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-1685-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:CBU_1713
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_0000167004Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei264 – 2641N6-(pyridoxal phosphate)lysineUniRule annotation

Proteomic databases

PRIDEiQ83B09.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi227377.CBU_1713.

Structurei

3D structure databases

ProteinModelPortaliQ83B09.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiWTGLMMI.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q83B09-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLIFEKSRKN RRTLAHAIAD KMDANDIPAN LLRHDAPRLP ELSELEVVRH
60 70 80 90 100
FTRLSTQNFS IDTHFYPLGS CTMKYNPRAA NRLASLPGYL KRHPLSPAPQ
110 120 130 140 150
SQAFLQCLYE LQTMLTEITG MEKISLTSMA GAQGEFAGVA MIKAYHESRG
160 170 180 190 200
DYDRTEMIVP DAAHGTNPAS AAMCGFTVKE ISTTKDGDID LEKLRQMAGA
210 220 230 240 250
KTAGIMLTNP STLGVFERQI SEVAKIIHNA GGLLYYDGAN LNAILGKYRP
260 270 280 290 300
GDMGFDVMHL NLHKTFATPH GGGGPGAGPV AAGPRLSKFL PVPMVGKNKE
310 320 330 340 350
GYDWLTEKEC PKSIGRLSAF MGNSGVLLRA YIYLRLLGKE GLSRVAEFST
360 370 380 390 400
LNANYLMKRL EQLGFTLAFP NRRASHEFII TLKPLTRAYG VTALDIAKRL
410 420 430 440 450
LDYGFHAPTI YFPLLVPECL LIEPTETESK QTLDHFIEAM EKILTEIKTT
460 470 480 490
PDLLRNAPHQ QLINRLDEVK AARELDLRWY PIAKETEIFI Q
Length:491
Mass (Da):54,619
Last modified:June 1, 2003 - v1
Checksum:iD7D0E3A1859A98F7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016828 Genomic DNA. Translation: AAO91208.1.
RefSeqiNP_820694.1. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO91208; AAO91208; CBU_1713.
GeneIDi1209624.
KEGGicbu:CBU_1713.
PATRICi17932157. VBICoxBur82552_1697.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016828 Genomic DNA. Translation: AAO91208.1 .
RefSeqi NP_820694.1. NC_002971.3.

3D structure databases

ProteinModelPortali Q83B09.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227377.CBU_1713.

Proteomic databases

PRIDEi Q83B09.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO91208 ; AAO91208 ; CBU_1713 .
GeneIDi 1209624.
KEGGi cbu:CBU_1713.
PATRICi 17932157. VBICoxBur82552_1697.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi WTGLMMI.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci CBUR227377:GJ7S-1685-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiGCSPB_COXBU
AccessioniPrimary (citable) accession number: Q83B09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: June 1, 2003
Last modified: October 1, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3